A5010776501- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- MRI in cancer diagnosis
- Advanced X-ray and CT Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
- Prostate Cancer Treatment and Research
- Cancer Immunotherapy and Biomarkers
- Neuroendocrine Tumor Research Advances
- Colorectal Cancer Treatments and Studies
- AI in cancer detection
- Brain Metastases and Treatment
- Head and Neck Cancer Studies
- Advanced Radiotherapy Techniques
- Cell Adhesion Molecules Research
- Neuroblastoma Research and Treatments
- Immunotherapy and Immune Responses
- Breast Cancer Treatment Studies
- Sarcoma Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Glioma Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Pancreatic and Hepatic Oncology Research
- Prostate Cancer Diagnosis and Treatment
Pitié-Salpêtrière Hospital
2024-2025
Inserm
2017-2025
Université Paris Cité
2025
Assistance Publique – Hôpitaux de Paris
2025
Centre de Recherche des Cordeliers
2025
Sorbonne Université
2024-2025
University Hospital of Lausanne
2021-2024
University of Lausanne
2019-2024
Hôpital Orthopédique de la Suisse Romande
2020-2021
Society of Nuclear Medicine and Molecular Imaging
2021
Textural and shape analysis is gaining considerable interest in medical imaging, particularly to identify parameters characterizing tumor heterogeneity feed radiomic models. Here, we present a free, multiplatform, easy-to-use freeware called LIFEx, which enables the calculation of conventional, histogram-based, textural, features from PET, SPECT, MR, CT, US images, or any combination imaging modalities. The application does not require programming skills was developed for professionals. goal...
Several reports have shown that radiomic features are affected by acquisition and reconstruction parameters, thus hampering multicenter studies. We propose a method that, removing the center effect while preserving patient-specific effects, standardizes measured from PET images obtained using different imaging protocols. <b>Methods:</b> Pretreatment <sup>18</sup>F-FDG of patients with breast cancer were included. In one nuclear medicine department (department A), 63 scanned on time-of-flight...
This paper relates the post-analysis of first edition HEad and neCK TumOR (HECKTOR) challenge. challenge was held as a satellite event 23rd International Conference on Medical Image Computing Computer-Assisted Intervention (MICCAI) 2020, its kind focusing lesion segmentation in combined FDG-PET CT image modalities. The challenge's task is automatic Gross Tumor Volume (GTV) Head Neck (H&N) oropharyngeal primary tumors FDG-PET/CT images. To this end, participants were given training set 201...
Background Immune checkpoint inhibitor (ICI)-related myocarditis is a rare but potentially fatal adverse event that can occur following ICI exposure. Early diagnosis and treatment are key to improve patient outcomes. Somatostatin receptor-based positron emission tomography–CT (PET/CT) showed promising results for the assessment of myocardial inflammation, yet information regarding its value ICI-related myocarditis, especially at early stage, limited. Thus, we investigated 68...
By focusing on metabolic and morphological tissue properties respectively, FluoroDeoxyGlucose (FDG)-Positron Emission Tomography (PET) Computed (CT) modalities include complementary synergistic information for cancerous lesion delineation characterization (e.g. outcome prediction), in addition to usual clinical variables. This is especially true Head Neck Cancer (HNC). The goal of the HEad neCK TumOR segmentation prediction (HECKTOR) challenge was develop compare modern image analysis...
Infectious endocarditis is a life-threatening disease, requiring prompt and accurate diagnosis. The aim of this article to perform systematic review meta-analysis the literature estimate performance fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) for diagnosis native valve (NVE).Selected articles evaluating diagnostic accuracy 18F-FDG PET/CT in patients with suspected NVE, resulting from comprehensive search through PubMed/MEDLINE Cochrane...
Background and aims. Immune checkpoint inhibitor-associated myocarditis (ICI-My) is a rare but potentially life-threatening complication. Advancing our understanding of its underlying immunological mechanisms essential for the development improved diagnostic tools targeted treatment strategies, with aim ultimately enhancing patient outcomes minimizing morbidity mortality. Methods. This retrospective single-center study (July 2019-June 2024) identified 33 patients who developed ICI-My. A...
A 76-year-old man presented with morning facial edema, forearm induration, testicular pain, and a major inflammatory syndrome. Contrast-enhanced CT was inconclusive. Conversely, FDG-PET/CT showed pathological uptake of medium-vessels, particularly in the right arm soft tissues, leading to diagnosis medium-vessel vasculitis. Symptoms vanished after methotrexate corticosteroid initiation. While undergoing progressive dose reduction, he lower limb myalgia. second confirmed relapse, extensive...
To assess the safety and efficacy of ipilimumab plus nivolumab around selective internal radiation therapy (SIRT) in patients with metastatic uveal melanoma (mUM). We present a retrospective, single center study 32 mUM divided into two groups based on treatment received between April 2013 2021. The SIRT_IpiNivo cohort was treated Yttrium-90 microspheres before or after SIRT (n = 18). underwent but did not receive combined immunotherapy 14). Twelve (66.7%) arm as first-line six (33.3%) prior...
Abstract Background Immune checkpoint inhibitors (ICIs) are reshaping the prognosis of many cancers, but often cause immune-related adverse events (irAEs). Among neurological irAEs, myositis is most frequently reported. Our aim to describe clinical and non-clinical characteristics, treatment outcome all irMyositis (skeletal limb-girdle and/or ocular myositis) irMyocarditis cases in our reference center. Methods We retrospectively enrolled irMyositis/irMyocarditis patients seen between 2018...
Metastatic dedifferentiated liposarcoma (DDLPS) is primarily managed with chemotherapy, yet poor response rate. Locoregional therapies, such as radiotherapy and percutaneous cryoablation, can provide palliation for inoperable metastatic sarcomas. In rare instances, those ablative therapies elicit an immune-mediated regression of untreated metastases in a process named the abscopal effect. With growing use immunotherapy, reports on effect have become more frequent during last decade.
Prostate-specific membrane antigen (PSMA)-targeted radioligand therapy is a validated treatment option for patients with advanced prostate cancer. Although PSMA expression not limited to tissue, little known about its relevance other types of Here, we present case report patient uterine leiomyosarcoma that progressing while on immunotherapy and treated 177 Lu-PSMA radionuclide therapy. We the first time combined outside did observe post-treatment reduction tumor growth rate, although notice...
Abstract Background Neoadjuvant endocrine therapy (NET) has shown efficacy in terms of clinical response and surgical outcome postmenopausal patients with estrogen receptor-positive / HER2-negative breast cancer (ER+/HER2- BC) but monitoring tumor is challenging. The aim the present study was to investigate value an early metabolic compared morphological pathological responses this population. Methods This ancillary CARMINA 02, a phase II trial evaluating side-by-side 4 6 months anastrozole...
Transarterial radioembolization (TARE) with 90Y-loaded microspheres is an established therapeutic option for inoperable hepatic tumors. Increasing knowledge regarding TARE dose-response and dose-toxicity correlation available but few studies have investigated in extra-hepatic tissues. We absorbed dose levels the appearance of focal lung damage a case off-target deposition 90Y compared them corresponding thresholds recommended to avoiding radiation induced injury following TARE. A 64-year-old...