A5067964964- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Gene expression and cancer classification
- Bioinformatics and Genomic Networks
- Genetic Associations and Epidemiology
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Face and Expression Recognition
- Neuroblastoma Research and Treatments
- Cancer-related molecular mechanisms research
- Genetics and Neurodevelopmental Disorders
- Epigenetics and DNA Methylation
- MRI in cancer diagnosis
- Medical Imaging Techniques and Applications
- Genetic and phenotypic traits in livestock
- Ferroptosis and cancer prognosis
- Neurobiology of Language and Bilingualism
- Fetal and Pediatric Neurological Disorders
- Circular RNAs in diseases
- Sparse and Compressive Sensing Techniques
- Brain Tumor Detection and Classification
- Morphological variations and asymmetry
- Sarcoma Diagnosis and Treatment
- Statistical Methods and Inference
- Genetic Mapping and Diversity in Plants and Animals
Université Paris-Saclay
2010-2023
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2008-2023
CEA Paris-Saclay
2018-2023
Centre National de la Recherche Scientifique
2011-2022
NeuroSpine Institute
2020-2021
Centro Universitário Una
2019
Laboratoire Traitement et Communication de l’Information
2019
Frédéric Joliot Institute for Life Sciences
2019
Laboratoire de Vectorologie et Thérapeutiques Anticancéreuses
2011-2018
Institut Gustave Roussy
2010-2018
Diffuse intrinsic pontine glioma (DIPG) is the most severe paediatric solid tumour, with no significant therapeutic progress made in past 50 years. Recent studies suggest that diffuse midline glioma, H3-K27M mutant, may comprise more than one biological entity. The aim of study was to determine clinical and variables impact their prognosis. Ninety-one patients classically defined DIPG underwent a systematic stereotactic biopsy were included this observational retrospective study. Histone H3...
Several reports have shown that radiomic features are affected by acquisition and reconstruction parameters, thus hampering multicenter studies. We propose a method that, removing the center effect while preserving patient-specific effects, standardizes measured from PET images obtained using different imaging protocols. <b>Methods:</b> Pretreatment <sup>18</sup>F-FDG of patients with breast cancer were included. In one nuclear medicine department (department A), 63 scanned on time-of-flight...
Diffuse intrinsic pontine glioma (DIPG) is one of the most frequent malignant pediatric brain tumor and its prognosis universaly fatal. No significant improvement has been made in last thirty years over standard treatment with radiotherapy. To address paucity understanding DIPGs, we have carried out integrated molecular profiling a large series samples obtained stereotactic biopsy at diagnosis. While chromosomal imbalances did not distinguish DIPG supratentorial tumors on CGHarrays, gene...
Regularized generalized canonical correlation analysis (RGCCA) is a generalization of regularized to 3 or more sets variables. RGCCA component-based approach which aims study the relationships between several The quality and interpretability components are likely be affected by usefulness relevance variables in each block. Therefore, it an important issue identify within block subsets significant active blocks. In this paper, extended address variable selection. Specifically, sparse (SGCCA)...
Methylation of cytosine residues within the CpG dinucleotide in mammalian cells is an important mediator gene expression, genome stability, X-chromosome inactivation, genomic imprinting, chromatin structure, and embryonic development. The majority sites methylated a nonrandom fashion, raising question how DNA methylation distributed along genome. Here, we focused on functions methyltransferase-3b (Dnmt3b), which deregulated activity linked to several human pathologies. We generated Dnmt3b...
Abstract Diffuse intrinsic pontine gliomas (DIPG) can not be cured with current treatment modalities. Targeted therapy in this disease would benefit from advanced technologies detecting relevant drugable mutations. Twenty patients classic newly diagnosed DIPG underwent stereotactic biopsies and were analyzed for the presence of 983 different mutations 115 oncogenes tumor‐suppressor genes using OncoMap, a mass spectrometric method allele detection. Our results identified oncogenic TP53 (40%),...
Diffuse midline glioma (DMG), H3 K27M-mutant, is a new entity in the updated WHO classification grouping together diffuse intrinsic pontine gliomas and infiltrating glial neoplasms of harboring same canonical mutation at Lysine 27 histones tail. Two hundred fifteen patients younger than 18 years old with centrally-reviewed pediatric high-grade (pHGG) were included this study. Comprehensive transcriptomic (n = 140) methylation 80) profiling was performed depending on material available, order...
Abstract Aphids are the leading pests in agricultural crops. A large-scale sequencing of 40,904 ESTs from pea aphid Acyrthosiphon pisum was carried out to define a catalog 12,082 unique transcripts. strong AT bias found, indicating compositional shift between Drosophila melanogaster and A. . An silico profiling analysis characterized 135 transcripts specific pea-aphid tissues (relating bacteriocytes parthenogenetic embryos). This project is first address genetics Hemiptera hemimetabolous insect.
Actionable fibroblast growth factor receptor 3 (FGFR3)-transforming acidic coiled-coil protein fusions (F3T3) are found in approximately 3% of gliomas, but their characteristics and prognostic significance still poorly defined. Our goal was to characterize the clinical, radiological, molecular profile F3T3 positive diffuse gliomas.We screened fusion by real-time (RT)-PCR FGFR3 immunohistochemistry a large series characterized for main genetic alterations, histology, clinical evolution. We...
Platelet-derived growth factor receptor A is altered by amplification and/or mutation in diffuse intrinsic pontine glioma (DIPG). We explored vitro on new DIPG models the efficacy of dasatinib, a multi-tyrosine kinase inhibitor targeting this receptor. Gene expression profiles were generated from 41 DIPGs biopsied at diagnosis and compared with signature associated sensitivity/resistance to dasatinib. panel 12 cell lines established biopsy diagnosis, serially passaged, characterized gene...
Ependymomas are glial neoplasms occurring in any location throughout the central nervous system and supposedly derived from radial glia cells. Recent data suggest that these tumors may have different biological clinical behaviors according to their location. Pediatric supratentorial infratentorial ependymoma (SE IE) were compared with respect radiological parameters immunohistochemistry (IHC). Neuronal markers specifically assessed by IHC quantitative PCR (qPCR). No single morphological or...
Language is a unique trait of the human species, which genetic architecture remains largely unknown. Through language disorders studies, many candidate genes were identified. However, such complex and multifactorial unlikely to be driven by only few case-control suffering from lack power, struggle uncover significant variants. In parallel, neuroimaging has significantly contributed understanding structural functional aspects in brain recent availability large scale cohorts like UK Biobank...
Few methodological studies regarding widely used textural indices robustness in MRI have been reported. In this context, study aims to propose some rules compute reliable from multimodal 3D brain MRI. Diagnosis and post-biopsy MR scans including T1, post-contrast T2 FLAIR images thirty children with diffuse intrinsic pontine glioma (DIPG) were considered. The hybrid white stripe method was adapted standardize intensities. Sixty then computed for each modality different regions of interest...
Tumour lesion segmentation is a key step to study and characterise cancer from MR neuroradiological images. Presently, numerous deep learning architectures have been shown perform well on the specific tumour type they are trained (e.g., glioblastoma in brain hemispheres). However, high performing network heavily given may poorly rare for which no labelled cases allows training or transfer learning. Yet, because some visual similarities exist nevertheless between common tumours, around it,...
The grey and white matter volumes are known to reduce with age. This cortical shrinkage is visible on magnetic resonance images conveniently identified by the increased volume of cerebrospinal fluid in sulci between two gyri. Here, we replicated this finding using UK Biobank dataset studied genetic influence these features aging. We divided all individuals genetically confirmed British ancestry into sub-cohorts (12,162 3435 subjects for discovery replication samples, respectively). found...
Identifying the genes that contribute to variability in brain regions involved language processing may shed light on evolution of structures essential emergence Homo sapiens. The superior temporal asymmetrical pit (STAP), which is not observed chimpanzees, represents an ideal phenotype investigate genetic variations support human communication. left STAP depth was significantly associated with a predicted enhancer annotation located 14q23.1 locus, between DACT1 and KIAA0586, UK Biobank...
Predicting H3.1, TP53, and ACVR1 mutations in DIPG could aid the selection of therapeutic options. The contribution clinical data multi-modal MRI were studied for these three predictive tasks. To keep maximum number subjects, which is essential a rare disease, missing considered. A model was proposed, collecting all available each patient, without performing any imputation. retrospective cohort 80 patients with confirmed at least one four MR modalities (T1w, T1c, T2w, FLAIR), acquired two...
Regularized generalized canonical correlation analysis (RGCCA) is a general multiblock data framework that encompasses several important multivariate methods such as principal component analysis, partial least squares regression, and versions of analysis. In this article, we extend RGCCA to the case where at one block has tensor structure. This method called multiway (MGCCA). Convergence properties MGCCA algorithm are studied, computation higher-level components discussed. The usefulness...
Abstract Extensive heterogeneity in autism spectrum disorder (ASD) has hindered the characterization of consistent biomarkers, which led to widespread negative results. Isolating homogenized subtypes could provide insight into underlying biological mechanisms and an overall better understanding ASD. A total 1093 participants from population-based “Healthy Brain Network” cohort (Child Mind Institute New York City area, USA) were selected based on score availability behaviors relevant ASD,...
We established a gene expression profile resulting from ricin exposure and demonstrated its ability to classify exposed<italic>vs.</italic>non-exposed mice with drop of blood using an integrated microfluidic cartridge.