A5054459168- Fetal and Pediatric Neurological Disorders
- Prenatal Screening and Diagnostics
- Advanced Neuroimaging Techniques and Applications
- Pregnancy and preeclampsia studies
- Hemoglobinopathies and Related Disorders
- Neonatal and fetal brain pathology
- Mitochondrial Function and Pathology
- MRI in cancer diagnosis
- Glioma Diagnosis and Treatment
- Congenital Diaphragmatic Hernia Studies
- Advanced MRI Techniques and Applications
- Neurological Complications and Syndromes
- Parvovirus B19 Infection Studies
- Functional Brain Connectivity Studies
- Acute Ischemic Stroke Management
- Pediatric Urology and Nephrology Studies
- Autism Spectrum Disorder Research
- Pelvic and Acetabular Injuries
- Metabolism and Genetic Disorders
- Urological Disorders and Treatments
- ATP Synthase and ATPases Research
- Neurological and metabolic disorders
- Cytomegalovirus and herpesvirus research
- Radiomics and Machine Learning in Medical Imaging
- Vascular Malformations Diagnosis and Treatment
Université Paris Cité
2016-2025
Hôpital Necker-Enfants Malades
2016-2025
Sorbonne Paris Cité
2014-2025
Assistance Publique – Hôpitaux de Paris
2015-2024
Institut Necker Enfants Malades
2012-2024
Structure fédérative de recherche Necker
2023-2024
Institut des Maladies Génétiques Imagine
2016-2023
Inserm
2013-2023
Délégation Paris 5
2009-2020
Trajectoires développementales & psychiatrie
2020
Sickle cell disease results from a homozygous missense mutation in the β-globin gene that causes polymerization of hemoglobin S. Gene therapy for patients with this disorder is complicated by complex cellular abnormalities and challenges achieving effective, persistent inhibition We describe our first patient treated lentiviral vector-mediated addition an antisickling into autologous hematopoietic stem cells. Adverse events were consistent busulfan conditioning. Fifteen months after...
Purpose To compare arterial spin labeling (ASL) data between low- and high-grade brain tumors in children to establish a cutoff distinguish from neoplasms assess potential correlations cerebral blood flow (CBF) quantitative histologic microvascular data. Materials Methods Approval was obtained the regional review board. ASL 129 2011 2015 were retrospectively analyzed. CBF relative most perfused area of each neoplasm contrast enhancement quantified with semiquantitative ratio. The correlation...
<h3>Objective</h3> To identify a consistent pattern of brain MRI imaging in primary complex I deficiency. Complex deficiency, major cause respiratory chain dysfunction, accounts for various clinical presentations, including Leigh syndrome. Human comprises seven core subunits encoded by mitochondrial DNA (mtDNA) and 38 nuclear (nDNA). Moreover, its assembly requires six known many unknown factors. date, no correlation between genotypes phenotypes has been found deficiencies. <h3>Design...
Background and Purpose— To evaluate hyperacute management of pediatric arterial ischemic stroke, setting up dedicated pathways is the first recommended step to prove feasibility safety such treatments. A regional stroke alert protocol including 2 centers in Paris-Ile-de-France area, France, was established. Methods— Consecutive patients (28 days–18 years) with confirmed who had acute recanalization treatment (intravenous r-tPA [recombinant tissue-type plasminogen activator], endovascular...
Objective To define the predictive value ( PV ) of known prognostic factors fetal infection with Cytomegalovirus following maternal primary <14 weeks gestation, at different time points pregnancy: end second trimester; prenatal magnetic resonance imaging MRI 32 gestation; and using all ultrasound scans performed in third trimester US 3rdT). Design A retrospective study. Setting Reference medicine unit. Population Sixty‐two fetuses infected gestation. Methods We defined second‐trimester...
The aim of this study was to describe the magnetic resonance imaging (MRI) findings and neurological neuropsychological outcomes in paediatric, diarrhoea-associated haemolytic-uraemic syndrome (D+HUS) with central nervous system impairment treated eculizumab, a monoclonal antibody.The 14-month single-centre prospective included seven children (three males, four females; age range 16 mo-7 y 8 mo; median 3 7 mo) typical D+HUS acute impairment. In phase disease, assessment brain (MRI),...
<h3>SUMMARY:</h3> Pediatric choroid plexus papillomas and carcinomas are highly vascularized neoplasms, which difficult to distinguish with conventional imaging. We aimed analyze the diagnostic accuracy of PWI, by using both pseudocontinuous arterial spin-labeling DSC-PWI. reviewed PWI 13 children neoplasms (7 6 carcinomas). quantified CBF, relative CBV in each lesion compared carcinomas. Relative CBF values were significantly higher for (<i>P</i> = .028). The median value was 1.7 (range,...
OBJECT Arterial spin labeling (ASL)-MRI is becoming a routinely used sequence for ischemic strokes, as it quantifies cerebral blood flow (CBF) without the need contrast injection. As brain arteriovenous malformations (AVMs) are highflow vascular abnormalities, increased CBF can be identified inside nidus or draining veins. The authors aimed to analyze relevance of ASL-MRI in diagnosis and follow-up children with AVM. METHODS performed retrospective analysis 21 patients who had undergone...
We aimed to evaluate the contribution of early magnetic resonance imaging (MRI) for presymptomatic diagnosis Sturge-Weber syndrome (SWS) in infants with a facial port-wine birthmark (PWB).Asymptomatic PWB who performed first MRI scan before 3 months and second after 9 were included this study. Leptomeningeal enhancement on T1-weighted four indirect signs leptomeningeal angioma (choroid plexus enlargement, cerebral atrophy, signal inversion white matter T2 hyposignal, T1 hypersignal) screened...
Data sharing is not applicable to this article as no new data were created or analyzed in study. Table S1 Comparator characteristics of studies included fetal morphology section review S2 annexes S3 biometry Please note: The publisher responsible for the content functionality any supporting information supplied by authors. Any queries (other than missing content) should be directed corresponding author article.
Aim To address risk of first or recurrent cerebral haemorrhage in children with sickle‐cell disease ( SCD ) who are being managed modern stroke prevention strategies. Method A systematically followed paediatric cohort was retrospectively studied over a 9‐year period. Haemorrhagic defined as intracranial occurrence aneurysm diagnosis during the study Ischaemic cerebrovascular ischaemic event transcranial Doppler/magnetic resonance imaging hallmarks finding Results Among 251 patients cohort,...
Atypical migraine with aura can be challenging to diagnose. Arterial-spin-labelling (ASL) is able non-invasively quantify brain perfusion. Our aim was report cerebral blood flow (CBF) alterations using ASL, at the acute phase of atypical in children.Paediatric patients were retrospectively included if (1) referred for neurological deficit(s), (2) underwent magnetic resonance imaging (MRI) presentation ASL sequence, and (3) had subsequent diagnosis aura. Neurological symptom-free controls...