A5089936252- Pharmacological Effects and Toxicity Studies
- Intramuscular injections and effects
- Parkinson's Disease Mechanisms and Treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Renal Transplantation Outcomes and Treatments
- Pharmacogenetics and Drug Metabolism
- Epilepsy research and treatment
- Platelet Disorders and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Metabolomics and Mass Spectrometry Studies
- Trace Elements in Health
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Electrochemical Analysis and Applications
- Blood disorders and treatments
- Drug Transport and Resistance Mechanisms
- Potassium and Related Disorders
- Mitochondrial Function and Pathology
- Food Allergy and Anaphylaxis Research
- Neuroscience of respiration and sleep
- Heavy Metal Exposure and Toxicity
- Renal Diseases and Glomerulopathies
- Plant-based Medicinal Research
- Antibiotics Pharmacokinetics and Efficacy
- Respiratory and Cough-Related Research
University Hospital Cologne
2015-2019
University of Zurich
2015-2019
University Hospital of Zurich
2015-2019
The underlying mechanisms of Parkinson´s disease are not completely revealed. Especially, early diagnostic biomarkers lacking. To characterize pathophysiological events, research is focusing on metabolomics. In this case-control study we investigated the metabolic profile 31 disease-patients in comparison to 95 neurologically healthy controls. investigation metabolites CSF was performed by a 12 Tesla SolariX Fourier transform-ion cyclotron resonance-mass spectrometer (FT-ICR-MS)....
Parkinson's disease (PD) is a neurodegenerative with complex etiology. Several factors are known to contribute the onset and its progression. However, complete underlying mechanisms still escaping our understanding. To evaluate possible correlations between metabolites metallomic data, in this research, we combined control study measured using two different platforms. For data sources, applied Block Sparse Partial Least Square Discriminant Analysis (Block-sPLS-DA) model that allows for...
<b><i>Background:</i></b> Bisoprolol and metoprolol are moderately lipophilic, beta(1)-selective betablockers reported to cause adverse effects in the central nervous system (CNS), such as sleep disturbance, suggesting that both drugs may reach relevant concentrations brain. CNS beta(2)-receptor blockade has been suspected be related effects. The higher molecular size of bisoprolol (325 Dalton) beta(1)-selectivity compared (267 would suggest a lower rate...
Mycophenolic acid (MPA), either given as an ester pro-drug or enteric-coated sodium salt, is the most commonly prescribed anti-proliferative immunosuppressive agent used following organ transplantation and widely applied in immune-mediated diseases. Clinicians are well aware of common adverse reactions related to MPA treatment, particular diarrhea, leukopenia infections. Here we report a case severe, persistent ascites associated with treatment. The otherwise unexplained intractable ascites,...
<b><i>Background:</i></b> A drug must reach the central nervous system (CNS) in order to directly cause CNS adverse effects (AEs). Our current study addressed pharmacokinetic (PK) background of assumption that concentrations hydrochlorothiazide (HCT) and ramiprilate may AEs such as headache drowsiness. <b><i>Methods:</i></b> In neurological patients, paired serum cerebrospinal fluid (CSF) samples were withdrawn simultaneously. Some them treated...
<b><i>Background:</i></b> Pantoprazole is a proton pump inhibitor drug mainly used for treating peptic diseases. Adverse effects of pantoprazole in the occasional central nervous system (CNS) include headache, vertigo and sleep disturbances. Data rats suggest that pumps are expressed inner ear epithelium choroid plexus, which would be potential target to mediate such effects. <b><i>Methods:</i></b> To assess distribution into human CNS despite...