A5082628380- Parathyroid Disorders and Treatments
- Dialysis and Renal Disease Management
- Magnesium in Health and Disease
- Pancreatitis Pathology and Treatment
- Chronic Kidney Disease and Diabetes
- Iron Metabolism and Disorders
- Growth Hormone and Insulin-like Growth Factors
- Genetic Syndromes and Imprinting
- Renal and related cancers
- Fibroblast Growth Factor Research
- Biomedical Research and Pathophysiology
- Epigenetics and DNA Methylation
- Alkaline Phosphatase Research Studies
- Cardiovascular Health and Disease Prevention
- Pediatric Urology and Nephrology Studies
- Vitamin D Research Studies
- Hemoglobinopathies and Related Disorders
- Blood properties and coagulation
- Folate and B Vitamins Research
- Bone health and osteoporosis research
- Liver Disease Diagnosis and Treatment
- Renal Diseases and Glomerulopathies
- Renal and Vascular Pathologies
- Cerebrovascular and Carotid Artery Diseases
- Therapeutic Uses of Natural Elements
Abu Dhabi Health Services
2025
The Royal Melbourne Hospital
2015-2024
The University of Melbourne
2017-2024
University Hospitals Coventry and Warwickshire NHS Trust
2024
GTx (United States)
2020
Eastern Health
2011-2019
Monash University
2011-2019
Harvard University
2019
Comprehensive Clinical Research
2019
Kaiser Permanente
2019
Medial arterial calcification is accelerated in patients with CKD and strongly associated increased rigidity cardiovascular mortality. Recently, a novel vitro blood test that provides an overall measure of propensity by monitoring the maturation time (T50) calciprotein particles serum was described. We used this to T50 prospective cohort 184 stages 3 4 CKD, median 5.3 years follow-up. At baseline, major determinants included higher phosphate, ionized calcium, bone osteoclastic activity,...
The purpose of this study was to investigate the roles androgenic and estrogenic mechanisms in stimulation structural growth plasma GH male puberty. To resolve these two possible mechanisms, we compared effect androgens treatment constitutional delay adolescence: an aromatizable androgen, testosterone (T), a nonaromatizable dihydrotestosterone (DHT). Nine adolescent males, Tanner stage 1 or 2, were studied before during with T enanthate (group A) DHT heptanoate B). After 2.5 months...
FGF23 measurement may have a role in the management of patients with chronic kidney disease (CKD).Our objective was to study biological variability plasma intact (iFGF23) and C-terminal (cFGF23) concentrations.Plasma samples were taken from 12 healthy adults at multiple time points on 2 consecutive days assess diurnal concentrations. Early-morning fasting nonfasting also over 6-wk period estimate components variation. Samples 170 volunteers used define reference intervals. concentrations...
Vascular stiffening occurs in normal ageing and is accelerated chronic kidney disease (CKD). calcification contributes to this the high incidence of vascular morbidity mortality population. A network inhibitors work concert reduce mineralization risk extra-osseous tissue. Fetuin-A an important systemic inhibitor ectopic calcification. fraction total circulating fetuin-A interacts with mineral ions form stable colloidal complexes, calciprotein particles (CPP), preventing deposition. We sought...
The formation of fetuin-A-containing calciprotein particles (CPP) may facilitate the clearance calcium phosphate nanocrystals from extracellular fluid. These crystals otherwise seed extra-osseous mineralization. Fetuin-A is a partially phosphorylated glycoprotein that plays critical role in stabilizing these particles, inhibiting crystal growth and aggregation. CPP removal thought to be predominantly mediated by cells reticuloendothelial system via type I II class A scavenger receptor...
Background and objectives Patients receiving hemodialysis are at risk of cardiovascular events. A novel blood test ( T 50 test) determines the individual calcification propensity blood. Design, setting, participants, & measurements was determined in 2785 baseline serum samples patients enrolled Evaluation Cinacalcet Therapy to Lower Cardiovascular Events (EVOLVE) trial results were related patient outcomes. Results Serum albumin, bicarbonate, HDL cholesterol, creatinine main factors...
Background: The liver-derived plasma protein fetuin-A is a systemic inhibitor of ectopic calcification. Fetuin-A stabilizes saturated mineral solutions by forming colloidal protein-mineral complexes called calciprotein particles (CPP). CPP are initially spherical, amorphous and soft, referred to as primary CPP. These spontaneously convert into secondary CPP, which larger, oblongate, more crystalline, less soluble. mediate excess transport clearance from circulation. Methods: We studied...
Significance Statement In patients with CKD, higher serum phosphate levels are associated increased fibroblast growth factor 23 (FGF23) levels, arterial calcification, and cardiovascular mortality. Limited trials assessing phosphate-lowering therapy have reported modest efficacy in lowering FGF23 during short-term follow-up CKD; the effect of these agents on markers remains uncertain. This randomized trial involving 278 participants stage 3b or 4 CKD (mean age 63 years) found no significant...
Proteinuria is a common pathological finding in renal disease. Examining the urinary protein electrophoretic pattern gives clues to site of origin protein. We hypothesized that type proteinuria, classified by urine electrophoresis and immunofixation (uPEI), may be predicted simply examining proportion higher molecular weight (e.g. albumin) total content.One thousand eleven patients, whose had been sent pathology department for uPEI, were analysed albumin creatinine ratio (uPCR uACR) reported...
Abstract In kidney disease, higher circulating levels of the mineral-regulating hormone fibroblast growth factor (FGF)-23 are predictive disease progression but direct pathogenic effects on unknown. We sought evidence local renal synthesis in response to unilateral ureteric obstruction mouse, and pro-fibrotic actions FGF23 vitro . Acute tubulointerstitial injury due stimulated by tubules, downregulated inactivating proprotein convertases, without systemic mineral metabolism. , had divergent...
Fetuin-A (Fet-A) is an important regulator of extracellular matrix mineralization. Fet-A plays a critical role in the formation and stabilization high molecular weight colloidal protein-mineral complexes known as calciprotein particles (CPP). The aim this study was to examine effects inflammation, renal function dialysis modality on serum CPP.This observational patients with chronic kidney disease (CKD) those inflammatory (CID) but normal function. Serum CPP were quantified indirectly by...
Chronic kidney disease (CKD) is an increasing public health issue. It therefore potentially highly advantageous to identify patients at risk of accelerated renal progression and death. Neutrophil gelatinase-associated lipocalin (NGAL) established urinary biomarker for acute injury, but it not known whether adding NGAL (uNGAL) measurements conventional factors will improve assessment in the setting chronic disease.This a prospective observational cohort study 158 with Stage 3 or 4 CKD. The...
Abstract Calciprotein particles, nanoscale aggregates of insoluble mineral and binding proteins, have emerged as potential mediators phosphate toxicity in patients with Chronic Kidney Disease. Although existing immunochemical methods for their detection provided compelling data, these approaches are indirect, lack specificity subject to a number other technical theoretical shortcomings. Here we developed rapid homogeneous fluorescent probe-based flow cytometric method the quantitation...
Although the kidney has capacity to repair after mild injury, ongoing or severe damage results in scarring (fibrosis) and an associated progressive loss of function. However, despite its universal significance, evidence highlights a population based heterogeneity trajectory chronic disease (CKD) these patients. To explain CKD phenotype requires understanding relevant risk factors for fibrosis. These include both extrinsic nature intrinsic such as age, gender, genetics, perpetual activation...
Bone-derived fibroblast growth factor 23 (FGF23) is an important endocrine regulator of mineral homeostasis with effects transduced by cognate FGF receptor (FGFR)1-α-Klotho complexes. Circulating FGF23 levels rise precipitously in patients kidney disease and portend worse renal cardiovascular outcomes. De novo expression has been found the heart following injury but its significance remains unclear. Studies showing that exposure to chronically high concentrations activates hypertrophic gene...
Significance Statement Patients with AKI suffer a staggering mortality rate of approximately 30%. Fibroblast growth factor 23 (FGF23) and phosphate (P i ) rise rapidly after the onset have both been independently associated ensuing morbidity mortality. This study demonstrates that dietary P restriction markedly diminished early in plasma FGF23 prevented , parathyroid hormone, calcitriol mice folic acid–induced (FA-AKI). Furthermore, provides evidence for -sensitive osseous Fgf23 mRNA...