A5050701098- Diabetes Management and Research
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Consumer Behavior in Brand Consumption and Identification
- Diabetes and associated disorders
- Digital Marketing and Social Media
- Management and Marketing Education
- Customer Service Quality and Loyalty
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Parathyroid Disorders and Treatments
- Medical Imaging and Pathology Studies
- Social and Intergroup Psychology
- Lipoproteins and Cardiovascular Health
- Cultural Differences and Values
- Diet and metabolism studies
- Ethics in Business and Education
- Heterotopic Ossification and Related Conditions
- Job Satisfaction and Organizational Behavior
- Marketing and Advertising Strategies
- Skin Diseases and Diabetes
- Adipose Tissue and Metabolism
- Nuclear Structure and Function
- Psychology of Moral and Emotional Judgment
- Consumer Retail Behavior Studies
Southern Connecticut State University
2010-2024
Prevention Group
2022
Eli Lilly (United States)
2004-2017
Indianapolis Zoo
2014
University of New Haven
2009
Indiana University – Purdue University Indianapolis
1993-2003
Eli Lilly (Singapore)
2003
Academy of Nutrition and Dietetics
2003
Pace University
2000
Indiana University School of Medicine
1993-1999
To evaluate the glycemic control, lipid effects, and safety of pioglitazone in patients with type 2 diabetes mellitus.Patients (n = 197) mellitus, a hemoglobin A1c (HbA1c) > or 8.0%, fasting plasma glucose (FPG) 7.7 mmol/l (140 mg/dl), C-peptide 0.331 nmol/l (1 ng/ml) were enrolled this 23-week multi-center (27 sites), double-blind clinical trial randomized to receive either placebo HCl 30 mg (pioglitazone), administered once daily, as monotherapy. Patients required discontinue all...
OBJECTIVE To evaluate whether LY2605541 results in lower fasting blood glucose (FBG) versus insulin glargine (GL). RESEARCH DESIGN AND METHODS This 12-week, randomized, open-label, Phase 2 study enrolled patients with type diabetes (hemoglobin A1c [A1C] ≤ 10.5%), taking metformin and/or sulfonylurea GL or NPH once daily. Patients converted to morning administration during lead-in were randomized 2:1 from (n = 248) 39) 195) 95) daily the morning. RESULTS At 12 weeks, FBG (mean ± SE) was...
Aims To compare the efficacy and safety of LY2963016 insulin glargine ( LY IGlar ) reference product L antus®) in combination with oral antihyperglycaemic medications patients type 2 diabetes T2D ). Methods This phase III , randomized, double‐blind, 24‐week study enrolled who were insulin‐naïve [glycated haemoglobin HbA1c ≥7 ≤11.0%] or previously on ≤11%) treated ≥2 medications. Patients randomized to receive once‐daily (n = 376) 380) for 24 weeks. The primary outcome was test...
Aim To describe the clinical effects of single and multiple doses a potent, selective, orally administered, small‐molecule antagonist human glucagon receptor, LY2409021 , in healthy subjects patients with type 2 diabetes. Methods was administered dose‐escalation studies to (n = 23) diabetes 9) as ( S tudy 1) daily 47) for 28 days 2). Safety, tolerability, pharmacokinetic PK ) pharmacodynamic PD assessments were made after receiving once‐daily (5, 30, 60 or 90 mg) days. Results well tolerated...
Seven siblings with hyperphosphatemic tumoral calcinosis were studied using metabolic measures. Serum phosphorus and 1,25-dihydroxycholecalciferol concentrations significantly increased serum parathyroid hormone 25-hydroxycholecalciferol decreased in these subjects. Metabolic balance studies done three of the showed positive calcium balances, reflected by gastrointestinal absorption renal excretion. These data suggest that a hereditary abnormality vitamin D metabolism may be present patients...
OBJECTIVE To compare effects of LY2605541 versus insulin glargine on daily mean blood glucose as part a basal-bolus regimen for type 1 diabetes. RESEARCH DESIGN AND METHODS In this randomized, Phase 2, open-label, 2 × crossover study, 137 patients received once-daily basal (LY2605541 or glargine) plus mealtime 8 weeks, followed by treatment weeks. Daily was obtained from 8-point self-monitored profiles. The noninferiority margin 10.8 mg/dL. RESULTS met and superiority criteria compared with...
To compare the efficacy and safety of LY2963016 insulin glargine (LY IGlar) reference product (Lantus®) (IGlar) in patients with type 1 diabetes (T1D).This phase III, randomized, open-label, 52-week study enrolled T1D [glycated haemoglobin (HbA1c) ≤11%] being treated basal (once-daily) bolus insulin. Patients were randomized to receive once-daily LY IGlar (n = 268) or 267) combination mealtime lispro for 52 weeks. The primary outcome was test non-inferiority (0.4% then 0.3% margin) as...
Purpose A first objective is to add insight into how constructs of ethnocentrism, xenocentrism and cosmopolitanism relate each other. Knowledge these overlap or work together in affecting consumer preferences will offer global marketers insights for designing appropriate marketing strategies. The second extend this knowledge by examining the correspondence three a nomological network dispositional concepts pertinent product positioning market segmentation. third empirically examine extent...
To test the influence of bedrest on insulin regulation leucine metabolism, six normal young men were subjected to a five-step hyperinsulinemic euglycemic clamp before and after 7 days strict bedrest. A primed-constant infusion [1-13C]leucine at 0.12 +/- 0.02 mumol.kg-1.min-1 was used. Before bedrest, basal rate appearance (Ra) intracellular oxidation 2.79 0.17 0.613 0.070 mumol.kg-1.min-1, respectively. Insulin caused dose-dependent reduction Ra minimum 1.64 0.08 0.322 0.039 respectively, in...
We have studied the effects of oral sulfonylurea agent glyburide to modulate insulin receptors on nontransformed human fibroblasts in tissue culture. When was added monolayers fibroblasts, a dose-dependent increase number cell surface observed with maximum effect (19% increase) seen at 1 microgram/ml glyburide. Insulin can induce loss these cells, and when are exposed 100 ng/ml for 6 h, approximately 60% initial complement lost. process insulin-induced receptor (or down regulation) presence...
Cultured human fibroblasts degrade insulin by a receptor-mediated process. When intracellular hormone degradation is inhibited chloroquine, 125I-labeled internalizes and accumulates intracellularly. In contrast, cultured IM-9 lymphocytes do not receptor-bound or accumulate in the presence of chloroquine. Insulin-induced receptor loss occurs both cell types, chloroquine inhibits this process but lymphocytes. Transglutaminase membrane-associated enzyme thought to mediate ligand-induced...
We evaluated the endogenous glucose production (EGP) and disposal rate (GDR) over a range of doses basal insulin peglispro (BIL) glargine in healthy subjects.This was single-center, randomized, open-label, four-period, incomplete-block, crossover study conducted eight male subjects. Subjects had 8-h euglycemic clamps performed with primed, continuous infusions BIL (5.1 to 74.1 mU/min) three dosing periods (20 or 30 mU/m(2)/min) fourth period, targeted achieve 50-100% suppression EGP....
Purpose The purpose of this paper is to examine the extent which personal values, moral foundations and gender-role identities affect, in sequence, consumers' constructions their ethnocentric cosmopolitan orientations. Achieving a better understanding psychological makeup consumer ethnocentrism cosmopolitanism should help managers design international market segmentation brand positioning strategies. Design/methodology/approach study's conceptual framework anchored attitude values theories,...
Diabetic control as judged by five criteria did not deteriorate after 6 months of fish oil compared to olive supplementation in 16 patients with NIDDM who were eating a low fat, high complex carbohydrate diet. Plasma total and VLDL triglyceride cholesterol decreased significantly supplementation; plasma HDL concentrations change. The LDL level was increased supplementation, suggesting that are given supplement decrease the levels may also need further dietary and/or pharmaceutical therapy...
Purpose This paper aims to develop a model that explains the moral bases of consumer ethnocentrism and cosmopolitanism as purchase dispositions. The authors build their work on foundations theory social theories Emile Durkheim. Design/methodology/approach Theory-building from general motivation is grounded in cultural norms, empirical research conducted test theoretical propositions. Findings focus implications binding or individualism morals consumers within groups. Consequently, variables...