A5075220516- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Parathyroid Disorders and Treatments
- Nitric Oxide and Endothelin Effects
- Cardiomyopathy and Myosin Studies
- Reproductive System and Pregnancy
- Signaling Pathways in Disease
- Antioxidant Activity and Oxidative Stress
- Endometriosis Research and Treatment
- Systemic Sclerosis and Related Diseases
- Atherosclerosis and Cardiovascular Diseases
- Aortic Thrombus and Embolism
- Uterine Myomas and Treatments
- Dermatological and Skeletal Disorders
- Eosinophilic Disorders and Syndromes
- Vascular Anomalies and Treatments
- Protein Kinase Regulation and GTPase Signaling
- Cardiovascular Health and Disease Prevention
- Insect symbiosis and bacterial influences
Boston University
2019-2023
Harvard University
2023
Massachusetts General Hospital
2023
Central Drug Research Institute
2015-2022
Vascular aging, aortic stiffness and hypertension are mechanistically interrelated. The perspective presented here will focus mainly on the molecular mechanisms of age-associated increases in vascular smooth muscle cell (VSMC). This review highlight by which VSMC contributes to disorders aging. Distinct functional sub-components protein-protein interactions, signaling intracellular trafficking processes setting aging aorta be detailed.
Abstract Smooth muscle cell (SMC) contraction and vascular tone are modulated by phosphorylation multiple modifications of the thick filament, thin filament regulation SMC has been reported to involve extracellular regulated kinase (ERK). Previous studies in ferrets suggest that actin‐binding protein, calponin 1 (CNN1), acts as a scaffold linking protein C (PKC), Raf, MEK ERK, promoting PKC‐dependent ERK activation. To gain further insight into this function CNN1 activation contractility...
Coronin proteins bind with actin filaments and participate in regulation of actin‐dependent processes. These contain a coiled‐coil domain at their C‐terminus, which is responsible for dimeric or trimeric forms. However, the functional significance these oligomeric configurations organizing cytoskeleton obscure. Here, we report that Leishmania coronin exists higher form through its domain, truncation ablates ability to assist actin‐filament formation. F‐actin co‐sedimentation assay using...
Twinfilin is an evolutionarily conserved actin-binding protein, which regulates actin-dynamics in eukaryotic cells. Homologs of this protein have been detected the genome various protozoan parasites causing diseases human. However, very little known about their core functions these organisms. We show here that a twinfilin homolog human pathogen Leishmania, primarily localizes to nucleolus and, some extent, also basal body region. In dividing cells, nucleolar redistributes mitotic spindle and...
Vascular calcification is a hallmark of atherosclerotic disease and serves as strong predictor risk factor for cardiovascular events. Growing evidence suggests that autophagy may play protective role in early atherosclerosis. The precise effects on VSMC-mediated remain unknown. In this study, we utilized multi-omic profiling to investigate impaired at the transcriptional level key driver VSMC calcification. Our findings revealed an essential determinant We observed osteogenic environment...
Introduction: Calciphylaxis is a rare, understudied disease of accelerated vascular calcification affecting the skin and soft tissue leading to painful wounds, amputations, reduced survival. The underlying mechanisms calciphylaxis remain incompletely understood. Objective: In this study, we aimed identify altered signaling pathways novel differentially expressed genes (DEGs) associated with characterize protein expression top DEGs in vasculature. Methods: 6 case 3 control tissues were...