A5052526592- Parasites and Host Interactions
- Research on Leishmaniasis Studies
- Asthma and respiratory diseases
- Helminth infection and control
- Parasite Biology and Host Interactions
- Genetic Associations and Epidemiology
- Child Nutrition and Water Access
- Hemoglobinopathies and Related Disorders
- T-cell and Retrovirus Studies
- Global Maternal and Child Health
- IL-33, ST2, and ILC Pathways
- Obesity, Physical Activity, Diet
- Nutritional Studies and Diet
- Trypanosoma species research and implications
- Genomics and Phylogenetic Studies
- Parasitic Infections and Diagnostics
- Galectins and Cancer Biology
- Urticaria and Related Conditions
- Eosinophilic Esophagitis
- Inflammasome and immune disorders
- Mosquito-borne diseases and control
- Agriculture Sustainability and Environmental Impact
- Macrophage Migration Inhibitory Factor
- Food Allergy and Anaphylaxis Research
- Toxin Mechanisms and Immunotoxins
Fundação Oswaldo Cruz
2013-2024
Universidade Federal de Mato Grosso
2020
Complexo Hospitalar Universitário Professor Edgard Santos
2004-2016
Universidade Federal da Bahia
2005-2014
Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais
2010-2012
National Council for Scientific and Technological Development
2008-2010
Hospital Ana Nery
2008
Tricoci University of Beauty Culture
2005
We used a deeply sequenced dataset of 910 individuals, all African descent, to construct set DNA sequences that is present in these individuals but missing from the reference human genome. aligned 1.19 trillion reads genome (GRCh38), collected failed align, and assembled into contiguous (contigs). then compared contigs one another identify unique representing regions pan-genome Our analysis revealed 296,485,284 bp 125,715 distinct populations demonstrating contains ~10% more than current...
Recombinant proteins expressed in Escherichia coli vectors are generally contaminated with endotoxin. In this study, we evaluated the ability of Polymyxin B to neutralize effect LPS present as contaminant on Schistosoma mansoni recombinant produced E. inducing TNF-alpha and IL-10. Peripheral blood mononuclear cells from individuals chronically infected S. were stimulated vitro Sm22.6, Sm14 P24 antigens (10 microg/mL) presence microg/mL).The levels cytokines measured using ELISA. There was...
Abstract The African Diaspora in the Western Hemisphere represents one of largest forced migrations history and had a profound impact on genetic diversity modern populations. To date, fine-scale population structure descendants remains largely uncharacterized. Here we present variation from deeply sequenced genomes 642 individuals North South American, Caribbean West populations, substantially increasing lexicon human genomic suggesting much to be discovered African-admixed populations...
A point-of-care test for detecting schistosome circulating cathodic antigen in urine (POCCCA) has been proposed mapping infection and defining prevalence thresholds mass drug administration (MDA). However, there is increasing evidence that POCCCA may yield false-positive results, which requires rigorous specificity evaluation non-endemic areas. was applied an area known to be free from devoid of any condition schistosomiasis transmission as part a multicentre study evaluate the performance...
Abstract To characterize the extent and impact of ancestry-related biases in precision genomic medicine, we use 642 whole-genome sequences from Consortium on Asthma among African-ancestry Populations Americas (CAAPA) project to evaluate typical filters databases. We find significant correlations between estimated African ancestry proportions number variants per individual all variant classification sets but one. The source these is highlighted more detail by looking at interaction filtering...
Ultra-processed food (UPF) consumption impacts nutrient intake and plays an important role in non-communicable diseases (NCD), even among schoolchildren. This cross-sectional study aimed to characterize the of this population its relationship with laboratory anthropometric aspects. A sample 190 subjects aged 5 19 y was randomly selected for dietary, laboratory, assessment. Statistical inference calculated using Spearman’s correlation. Excess weight observed 34%, a high Waist-to-Height Ratio...
Helminthic infections have been shown to inhibit allergy skin-prick tests and modify the course of asthma. We evaluated Dermatophagoides pteronyssinus-specific immune responses in patients with asthma by measuring levels T helper 2 (Th2) cytokines peripheral blood mononuclear cell (PBMC) cultures. PBMCs from Schistosoma mansoni-infected living an area polyhelminthic endemicity produced lower interleukin (IL)-5 IL-4 response D. pteronyssinus antigen (Ag) 1 than did helminth-free In contrast,...
Summary Schistosoma mansoni infection has been associated with protection against allergies. The mechanisms underlying this association may involve regulatory cells and cytokines. We evaluated the immune response induced by S. antigens Sm22·6, PIII Sm29 in a murine model of ovalbumin (OVA)-induced airway inflammation. BALB/c mice were sensitized subcutaneously injected OVA-alum challenged aerolized OVA. Mice given three doses different antigens. Lung histopathology, cellularity...
To identify the main bacterial species associated with community-acquired urinary tract infection (UTI) and to assess pattern of ciprofloxacin susceptibility among bacteria isolated from urine cultures.We conducted a retrospective study in all patients UTI seen Santa Helena Laboratory, Camaçari, Bahia, Brazil during five years (2010-2014). All individuals who had positive culture result were included this study.A total 1,641 met inclusion criteria. Despite fact that participants female, we...
Background: The World Health Organization recommends a market-ready, urine-based point-of-care diagnostic test for circulating cathodic antigens (CCA) to determine the prevalence of S. mansoni. This study evaluated performance URINE CCA (SCHISTO) ECO TESTE® (POC-ECO), which is currently available in Brazil. Methods: Residents from eight sites with different estimates provided one urine sample POC-ECO and stool Kato-Katz (KK) Helmintex® (HTX) testing as an egg-detecting reference infection...
ABSTRACT Characterization of genetic admixture populations in the Americas and Caribbean is interest for anthropological, epidemiological, historical reasons. Asthma has a higher prevalence more severe with high African component. Association ancestry asthma been demonstrated. We estimated proportions samples from six trihybrid descent determined relationship between total serum IgE levels (tIgE). genotyped 237 informative markers asthmatics nonasthmatic controls Barbados (190/277), Jamaica...
ABSTRACT Although most T lymphocytes express the αβ T-cell receptor and either CD4 or CD8 molecules, a small population of cells lacking these coreceptors, − (double negative [DN]) cells, has been identified in peripheral immune system mice humans. To better understand role that this may have human response against Leishmania spp., detailed study defining activation state, cytokine profile, heterogeneity DN bearing γδ receptors was performed with group well-defined cutaneous leishmaniasis...
Rationale: Asthma prevalence and severity are high among underserved minorities, including those of African descent. The Duffy antigen/receptor for chemokines is the receptor Plasmodium vivax on erythrocytes functions as a chemokine-clearing receptor. Unlike European populations, decreased expression common populations descent, results from functional T-46C polymorphism (rs2814778) in promoter. This variant provides an evolutionary advantage malaria-endemic regions, because...
Abstract A primary goal of The C onsortium on sthma among frican-ancestry P opulations in the mericas (CAAPA) is to develop an ‘African Diaspora Power Chip’ (ADPC), a genotyping array consisting tagging SNPs, useful comprehensively identifying African specific genetic variation. This designed based novel variation identified 642 CAAPA samples ancestry with high coverage whole genome sequence data (~30× depth). extends pattern catalogued 1000 Genomes and Exome Sequencing Projects spectrum...
Aimed at improving the quality of school meals, Sustainable School Program (SSP) implemented low-carbon twice a week, in 155 schools 4 municipalities, reaching more than 32,000 students. This study evaluated environmental impact and nutritional viability this intervention for population. The 15 most repeated meals from conventional sustainable menus were selected, we considered age group number served per student/day. Nutritional information was calculated using validated food composition...
Despite the availability of many parasitological methods for detection Cryptosporidium and Isospora (Cystoisospora) belli in fecal samples, there are uncertainties about accuracy these techniques laboratory practice. In this study, 27 formalin-fixed positive stool samples 15 I. were analyzed by 2 concentration methods, sedimentation centrifugation (SC) formalin–ethyl acetate (FE), 3 tintorial techniques, modified Ziehl-Neelsen (ZN), safranin (SF), auramine (AR). No significant differences...
Detailed knowledge of factors associated with resistance to Schistosoma mansoni infection in endemic areas might facilitate more effective schistosomiasis control. We conducted a cross-sectional study persons resistant and found no association between socioeconomic status infection. Mononuclear cells subjects produced higher levels interleukin-5 (IL-5), IL-13 interferon-γ upon stimulation soluble egg antigen (SEA) compared infected persons. When stimulated Sm21.6 or Sm22.6, IL-10 were cell...
Summary Field studies have suggested an immune‐mediated mechanism associated with resistance to Schistosoma mansoni infection. Overall, levels of specific IgE been correlated infection, whereas IgG4 susceptibility. This study aimed evaluate serum soluble adult worm antigen preparation (SWAP)‐specific and in relation current infection a large casuistic individuals living endemic area schistosomiasis Bahia, Brazil. The prevalence S. was 37·7% the mean parasite burden 55·4 (0–2100) epg/faeces....
Evidence of genetic control for total serum IgE (tIgE) level has been reported in multiple populations, although populations with substantial exposure to helminths have yielded lower estimates heritability, despite evidence suggesting that genes also a significant portion the variation number Schistosoma mansoni eggs per gram fecal matter.By use whole-population ascertainment scheme, 822 individuals were enrolled from schistosomiasis-endemic area Conde, Bahia, Brazil. Heritability was...
Background IL-13 is a signature cytokine of the helper T cell type 2 (TH2) pathway which underlies host defense to helminthic infection and activates production IgE in both parasitized populations urban settings after allergen exposure. Methodology/Principal Findings Two functional polymorphisms IL13, rs1800925 (or c.1-1111C>T) rs20541 R130Q) were previously found be associated with Schistosoma hematobium intensity. They have not been thoroughly explored S. mansoni-endemic populations,...
The World Health Organization (WHO) recognizes schistosomiasis as one of the Neglected Tropical Diseases targeted for global elimination in 2030 Agenda Sustainable Development Goals. In Brazil, mansoni is considered a public health problem, particularly prevalent among vulnerable populations living areas with poor environmental and sanitary conditions. 2022, WHO published Guideline encompassing recommendations to assist national programs endemic countries achieving morbidity control,...