A5080147904- Inflammatory Bowel Disease
- Microscopic Colitis
- Gut microbiota and health
- Genetic Associations and Epidemiology
- Asthma and respiratory diseases
- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- Ectopic Pregnancy Diagnosis and Management
- Eosinophilic Esophagitis
- Gastrointestinal Tumor Research and Treatment
- Diagnosis and treatment of tuberculosis
- Biosimilars and Bioanalytical Methods
- Liver Disease Diagnosis and Treatment
- COVID-19 and Mental Health
- Health Systems, Economic Evaluations, Quality of Life
- Diverticular Disease and Complications
- SARS-CoV-2 and COVID-19 Research
- Pregnancy and Medication Impact
- Chronic Lymphocytic Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Biliary and Gastrointestinal Fistulas
- Colorectal Cancer Treatments and Studies
- Research on Leishmaniasis Studies
- Cytomegalovirus and herpesvirus research
- Mycobacterium research and diagnosis
Vall d'Hebron Hospital Universitari
2020-2025
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2022-2023
Vall d'Hebron Institut de Recerca
2021-2022
Universidad Católica de Honduras Nuestra Señora Reina de la Paz
2016-2019
ABSTRACT Background Leishmaniasis (LI) is a vector‐borne illness caused by protozoan of the genus Leishmania . Data on features LI in patients with inflammatory bowel disease (IBD) are scarce. Aim To describe characteristics IBD who present leishmaniasis, infection outcomes and risk factors associated developing visceral leishmaniasis (VL). Methods An observational retrospective study performed 26 hospitals Spain, including all adult developed from 2012 to 2022. Results A total 73 were...
Abstract The African Diaspora in the Western Hemisphere represents one of largest forced migrations history and had a profound impact on genetic diversity modern populations. To date, fine-scale population structure descendants remains largely uncharacterized. Here we present variation from deeply sequenced genomes 642 individuals North South American, Caribbean West populations, substantially increasing lexicon human genomic suggesting much to be discovered African-admixed populations...
Crohn's disease (CD) and ulcerative colitis (UC), the two main forms of inflammatory bowel (IBD), affect several million people worldwide. CD UC are characterized by periods clinical remission relapse. Although IBD patients present chronic alterations gut microbiome, called dysbiosis, little attention has been devoted to relapse-related microbiome. To address this gap, we generated shotgun metagenomic data from stools European cohorts-134 Spanish (followed up for one year) 49 Belgian 6...
Abstract Background Microbiome studies report low gut microbial richness and diversity in ulcerative colitis (UC) patients. We explored whether UC patients who reach long-term clinical, endoscopic, histological remission show a ecosystem that is similar to healthy individuals. Methods collected 184 stool samples from 111 individuals (UC long remission, short flare, control subjects). Microbiota was analyzed by amplicon sequencing (16S ribosomal RNA) quantitative polymerase chain reaction for...
Abstract Background In inflammatory bowel disease, altered microbial states of the gut ecosystem could influence response to treatment. Our objective was investigate possibility predicting vedolizumab using markers microbiome. Methods To this end, we analysed characteristics microbiome shotgun metagenomic sequencing in 21 patients with active ulcerative colitis, eligible for treatment vedolizumab. The protocol included assessment clinical activity and analysis faecal samples prior at weeks...
Abstract Background Sexual dysfunction (SD) is common in patients with Inflammatory Bowel Disease (IBD), yet previous research identified depression as a key confounding factor. This the first study to exclude participants depression, aiming isolate impact of IBD on sexual health. Methods Adults confirmed and non-IBD controls were enrolled. A Hospital Anxiety Depression Scale1 (HADS) score >16 was an exclusion criteria. function assessed validated tools: Desire Inventory2 (SDI) for...
Abstract Background Leishmaniasis (LI) is a vector-borne illness caused by protozoan of the genus Leishmania. Data on features LI in patients with inflammatory bowel disease (IBD) are scarce. Aim To describe characteristics IBD who present LI, infection outcomes and risk factors associated developing visceral leishmaniasis (VL). Methods Observational, retrospective study performed 26 hospitals Spain, including all adult developed from 2012 to 2022. Results A total 73 were included. The...
Abstract Background Vedolizumab (VDZ) is a selective biologic agent that available in both intravenous (IV) and subcutaneous (SC) forms for maintenance treatment. The SC route offers advantages such as the convenience of self-administration, although some patients may prefer IV route. aim our study was to determine patients’ preferences satisfaction with their treatment when switching VDZ or continuing an administration. Methods A prospective, observational conducted inflammatory bowel...
Abstract Background Despite the high prevalence of diverticulosis in population, segmental colitis associated with (SCAD) is uncommon. Due to its overlap characteristics typical inflammatory bowel diseases, especially Ulcerative Colitis (UC), a possible link pathogenesis has been postulated, some cases disease progression from one other described. We present series SCAD that progressed UC Methods describe followed at our IBD Unit Hospital Universitari Vall d’Hebron were subsequently...
Abstract Background Ustekinumab (UST) is a monoclonal antibody targeting the p40 subunit of interleukin-12/23. Evidence suggests relationship between UST concentrations and therapeutic outcomes. This study aimed to evaluate association trough during induction phase clinical especially endoscopic outcomes at week 24 in patients with Crohn’s disease (CD) ulcerative colitis (UC). Methods Patients CD UC were included from start treatment. Intensification maintenance regimens based on standard...
Abstract A primary goal of The C onsortium on sthma among frican-ancestry P opulations in the mericas (CAAPA) is to develop an ‘African Diaspora Power Chip’ (ADPC), a genotyping array consisting tagging SNPs, useful comprehensively identifying African specific genetic variation. This designed based novel variation identified 642 CAAPA samples ancestry with high coverage whole genome sequence data (~30× depth). extends pattern catalogued 1000 Genomes and Exome Sequencing Projects spectrum...
Microbiome sequence data have been used to characterize Crohn's disease (CD) and ulcerative colitis (UC). Based on these data, we previously identified microbiomarkers at the genus level predict CD relapse. However, microbial load was underexplored as a potential biomarker in inflammatory bowel (IBD). Here, sought study use of fungal bacterial loads biomarkers detect both UC We analyzed fecal 294 stool samples obtained from 206 participants using real-time PCR amplification ITS2 region 16S...
immune checkpoint inhibitors (ICI) are increasingly used to treat several types of cancer. These drugs lead a wide range toxicities. Immune-related gastrointestinal adverse events common and potentially severe. In this manuscript, we recount the real clinical experience in tertiary center.a retrospective observational study was conducted adult patients under ICI treatment. Included had been referred Gastrointestinal Service Hospital Universitario Vall d'Hebron for evaluation severe...
The development of biomarkers for inflammatory bowel disease (IBD) diagnosis would be relevant in a generalized context. However, intercontinental investigation on these microbial remains scarce. We examined taxonomic microbiome variations IBD using published DNA shotgun metagenomic data. For this purpose, we used sequenced data from our previous Spanish Crohn's (CD) and ulcerative colitis (UC) cohort, downloaded sequence Chinese CD functional profiling tables USA UC cohort. At the global...
Liver injury has been widely described in patients with Coronavirus disease 2019 (COVID-19). We aimed to study the effect of liver biochemistry alterations, previous disease, and value elastography on hard clinical outcomes COVID-19 patients. conducted a single-center prospective observational 370 consecutive admitted for polymerase chain reaction (PCR)-confirmed pneumonia. Clinical laboratory data were collected at baseline parameters events recorded during follow-up. Transient [with...
To report the impact of COVID-19 pandemic on activity nurses working an inflammatory bowel disease (IBD) unit and to identify reasons for telehealth care its relationship certain characteristics. The had led increase in demand remote patients with who require monitoring frequent access health services. A retrospective study all (in person by phone call or email) done during acute phase at a reference hospital Spain. Numbers activities nurses, sociodemographic clinical data were collected....
ustekinumab is a fully human monoclonal antibody against IL-12/23, approved for induction and maintenance treatment of Crohn's disease (CD). Real-life data shows its true effectiveness in terms clinical endoscopic response. However, there little information regarding health-related quality life (HRQoL) CD patients receiving ustekinumab. The main aim this study was to define long-term remission HRQoL normalization. predictive factors were investigated as secondary aim.a retrospective,...
Background and aims: inflammatory bowel disease (IBD) affects many aspects of a patient's life impairs their health-related quality (HRQoL).The COVID-19 outbreak has led to important mobility restrictions dramatic re-adjustment social habits health systems.This study aimed assess the influence on HRQoL IBD patients with stable clinical remission biologic treatment.Their selfperceived stress scores during were also assessed.Methods: prospective, observational was performed in treatment...
Abstract Background Thiopurine therapy is associated with an increased risk of serious adverse events in patients Inflammatory Bowel Disease (IBD). S-methyltransferase (TPMT) the enzyme responsible for metabolism, and its determination helps identify at toxicity. This study aims to explore level correspondence between TPMT genotype enzymatic activity (phenotype) objective preventing prior commencement thiopurine therapy. Methods Consecutive IBD, Crohn’s (CD) or Ulcerative Colitis (UC), were...
Abstract Background Infliximab (IFX) and Adalimumab (ADA) are effective treatments for managing Inflammatory Bowel Disease (IBD) but treatment failure is common. Therapeutic drug monitoring (TDM) of trough serum concentrations (C Trough) has been used to optimize induction, mitigate immunogenicity, ensure appropriate exposure. HLA DQA1*05 genotype variants have identified as predictors immunogenicity. This study aimed investigate the impact dashboard-guided optimized induction dosing...
Abstract Background Ustekinumab, an anti-interleukin 12/23 agent, was approved by the European Medicines Agency in 2019 as a treatment for moderate-to-severe ulcerative colitis (UC). Limited real-world data is available regarding utilization of ustekinumab UC, particularly medication persistence and escalation, which are indicators performance settings. Our aim to describe our experience with refractory UC patients. Methods This observational single-center study on patients who received at...
Abstract Background SARS-CoV-2 mRNA vaccine induces a robust immune response in most patients with inflammatory bowel disease (IBD). However, humoral short-term appears to be reduced receiving anti-TNF agents or tofacitinib, even after booster doses. Data on long-term is limited. We aimed assess short and T-cell IBD and/or thiopurines. Methods A prospective, longitudinal study was carried out thiopurines, mono, combo therapy. Patients had received between 2 4 doses of vaccine. Cellular the...
Abstract Background Inflammatory bowel disease (IBD) affects many aspects of a patient’s life and impairs their health-related quality (HRQoL). We previously showed that there was negative impact the COVID-19 outbreak on HRQoL IBD patients in remission. This study aimed to assess if stable, clinical remission could recover pre-outbreak once global emergency for ended. also compared self-perceived stress scores during after outbreak. Methods carried out prospective, observational with...
Abstract Background It is unclear whether ustekinumab (UST) concentrations can predict the clinical course of inflammatory bowel disease (IBD) and guide treatment algorithms during induction phase. The aim our study was to assess association between serum UST phase outcomes at week 24 determine validity a threshold for guiding intensification strategies. Methods We conducted retrospective including Crohn's (CD) ulcerative colitis (UC) patients who started June 2022 February 2023....