A5072931927- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Neonatal Health and Biochemistry
- Hemoglobin structure and function
- Leptospirosis research and findings
- Heme Oxygenase-1 and Carbon Monoxide
- Inflammasome and immune disorders
- Folate and B Vitamins Research
- Streptococcal Infections and Treatments
- Health Education and Validation
- Blood properties and coagulation
- Pneumonia and Respiratory Infections
- Health Systems, Economic Evaluations, Quality of Life
- Nitric Oxide and Endothelin Effects
- Trace Elements in Health
- Paraoxonase enzyme and polymorphisms
- Epigenetics and DNA Methylation
- Regulation of Appetite and Obesity
- Erythrocyte Function and Pathophysiology
- Blood groups and transfusion
- Otolaryngology and Infectious Diseases
Fundação Oswaldo Cruz
2013-2023
University College London
2023
Complexo Hospitalar Universitário Professor Edgard Santos
2015-2021
Universidade Federal da Bahia
2013-2021
The aim of the present study was to characterize sickle cell disease retinopathy in children and teenagers from Bahia, state northeastern Brazil with highest incidence prevalence disease. A group 51 patients (36 hemoglobin SS 15 SC) ages ranging 4 18 years studied. Ophthalmological examinations were performed all patients. Moreover, a fluorescein angiography also over 10-year-old most common ocular lesions vascular tortuosity, which found nine (25%) patients, black sunburst, three (20%) SC...
This study investigated associations between SNPs in genes encoding metabolizing drug enzymes and laboratory parameters sickle cell anemia patients under hydroxyurea (SCA-HU + ). We evaluated hematologic biochemical by electronic methods PCR-RFLP multiplex PCR 35 SCA-HU 67 − patients. The HbS, total cholesterol, lactate dehydrogenase, aspartate aminotransferase, bilirubin fractions levels, leukocyte, eosinophil, monocyte, erythroblast counts were reduced (<mml:math...
This study investigated the effects of hydroxyurea (HU) on hematological, biochemical and inflammatory parameters in children with sickle cell anemia (SCA) association βS haplotype α-thalassemia. We included 22 SCA who were followed for an average 14.5 months. Laboratory assessed by electronic methods, molecular analysis was PCR-RFLP allele-specific PCR. Results showed significant increases hemoglobin, HbF, hematocrit, MCV, MCH, glucose, HDL-C albumin levels, as well decreases MCHC AST WBC,...
Alpha-1 antitrypsin (AAT) is an inhibitor of neutrophil elastase and a member the serine proteinase (serpin) superfamily, little known about its activity in sickle cell disease (SCD). We hypothesize that AAT may undergo changes SCD because high oxidative stress inflammation associated with disease. have found levels patients compared to controls, while mutant genotypes SERPINA1 gene had decreased levels, both groups. showed negative correlation red blood cells, hemoglobin (Hb), hematocrit,...
Transforming growth factor beta (TGF-β) is a cytokine with important involvement in biological processes related to the pathogenesis of sickle cell disease (SCD), including endothelial and vascular dysfunction, inflammation, hematopoietic homeostasis. This study aimed at investigating associations between levels TGF-β1 classical laboratory biomarkers inflammatory mediators, as well tissue inhibitor metalloproteases-1 (TIMP-1) matrix metalloproteinase-9 (MMP-9), pediatric patients (n = 123)...
Sickle cell anemia (SCA) patients have vascular complications, and polymorphisms in endothelin-1 (ET-1) endothelial nitric oxide synthase (eNOS) genes were associated with ET-1 disturbance. We investigate the association of 5665G>T eNOS -786T>C soluble adhesion molecules (sVCAM-1 sICAM-1), biochemical markers, medical history. studied 101 SCA patients; carriers minor allele (C) had highest levels sVCAM-1, more occurrence acute chest syndrome (ACS). The multivariate analysis suggested...
We investigated the nasopharynx and oropharynx microbiota in sickle cell disease (SCD) to identify microorganisms, antibiotic sensitivity, prevalent serotypes, association of with laboratorial markers. Oropharynx/nasopharynx secretions were 143 SCD children aging 6 months 17 years. Pathogens isolated using standard procedures, markers performed by automated methods. Staphylococcus aureus (S. aureus) was from 64 respectively. Streptococcus pneumoniae pneumoniae) eight patients. Serotypes S....
Sickle cell disease (SCD) patients often exhibit a dyslipidemic sub-phenotype. Paraoxonase 1 (PON 1) is serum glycoprotein associated with the high-density lipoproteins cholesterol (HDL-C), and variability in PON1 activity depends on genotypes. We investigated influence of PON1c.192Q > R PON1c.55L M polymorphisms laboratory parameters association between clinical manifestations SCD patients. recruited 350 individuals, including 154 196 healthy volunteers, which comprised control group....
Leptospirosis in humans usually involves hypokalaemia and hypomagnesaemia the putative mechanism underlying such ionic imbalances may be related to nitric oxide (NO) production. We previously demonstrated correlation between serum levels of NO severity renal disease patients with severe leptospirosis. Methylene blue inhibits soluble guanylyl cyclase (downstream action any synthase isoforms) was recently reported have beneficial effects on clinical experimental sepsis. investigated occurrence...
Leptospirosis in humans usually involves hypokalaemia and hypomagnesaemia the putative mechanism underlying such ionic imbalances may be related to nitric oxide (NO) production. We previously demonstrated correlation between serum levels of NO severity renal disease patients with severe leptospirosis. Methylene blue inhibits soluble guanylyl cyclase (downstream action any synthase isoforms) was recently reported have beneficial effects on clinical experimental sepsis. investigated occurrence...
Introdução: A avaliação de tecnologias em saúde (ATS) dispositivos médicos é desafiadora. Apesar ser uma área com que podem dispendiosas para o sistema saúde, pouco se fala sobre a ATS relação equipamentos e reagentes uso laboratorial. Objetivos: Identificar foi publicado na literatura científica, nos últimos dez anos, da tomada decisões nas análises clínicas. Métodos: Consiste revisão sistemática qual foram utilizadas as bases dados PubMed BVS/Lilacs. Após triagem inicial, feita dos textos...