A5082252634- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Heavy Metal Exposure and Toxicity
- Folate and B Vitamins Research
- Reproductive Health and Contraception
- Epigenetics and DNA Methylation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Heavy metals in environment
- Cervical Cancer and HPV Research
- Bone and Joint Diseases
- Mercury impact and mitigation studies
- Pesticide Exposure and Toxicity
- Heme Oxygenase-1 and Carbon Monoxide
- Neonatal Health and Biochemistry
- Trace Elements in Health
- Inflammasome and immune disorders
- Viral-associated cancers and disorders
- Head and Neck Cancer Studies
- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Parasitic Infections and Diagnostics
- Blood groups and transfusion
- Reproductive tract infections research
- RNA modifications and cancer
Instituto Federal da Bahia
2023
Universidade Federal da Bahia
2013-2022
Fundação Oswaldo Cruz
2016-2018
Universidade Federal do Rio Grande do Sul
2014
Universidade Federal do Amazonas
2011
In this study, we evaluate the association of different clinical profiles, laboratory and genetic biomarkers in patients with sickle cell anemia (SCA) hemoglobin SC disease (HbSC) attempt to characterize (SCD) genotypes.We conducted a cross-sectional study from 2013 2014 200 SCD individuals (141 SCA; 59 HbSC) analyzed demographic data population. addition, determined hematological, biochemical markers including βS-globin gene haplotypes 3.7 Kb deletion α-thalassemia (-α3.7Kb-thal), as well...
Sickle cell anemia (SCA) patients exhibit sub-phenotypes associated to hemolysis and vaso-occlusion. The disease has a chronic inflammatory nature that been also alterations in the lipid profile. This study aims analyze hematological biochemical parameters provide knowledge about SCA previously described suggest dyslipidemic sub-phenotype.A cross-sectional was conducted from 2013 2014, 99 steady state were enrolled. We assessed correlations associations with data investigated co-inheritance...
<i>Background:</i> We established for the first time prevalence of <i>Chlamydia trachomatis</i> infection among infertile women in Manaus Amazonas Brazil using polymerase chain reaction (PCR) technique. <i>Methods:</i> 106 were studied at a public university hospital fertility clinic infertility problems correlated with chlamydia infection. Social-economic and clinical information was obtained before medical examination to obtain samples amplification...
This study investigated associations between SNPs in genes encoding metabolizing drug enzymes and laboratory parameters sickle cell anemia patients under hydroxyurea (SCA-HU + ). We evaluated hematologic biochemical by electronic methods PCR-RFLP multiplex PCR 35 SCA-HU 67 − patients. The HbS, total cholesterol, lactate dehydrogenase, aspartate aminotransferase, bilirubin fractions levels, leukocyte, eosinophil, monocyte, erythroblast counts were reduced (<mml:math...
Reference values for cerebral blood flow velocity (CBFV) in hemoglobin SC disease (HbSC) have not been established. We aimed to investigate associations between laboratory and genetic biomarkers associated with CBFV HbSC children. Sixty-eight children were included; was analyzed by transcranial Doppler, the time-averaged maximum mean (TAMMV) estimated. Hematological, biochemical, immunological, analyses performed. TAMMV negatively correlated red cell count (RBC) count, hemoglobin,...
Abstract BACKGROUND: Protein p16 INK4a immunocytochemistry (ICCp16) has the potential to reveal lesions at risk of progression anal cancer. This study examined measures diagnostic validity ICCp16 in HIV‐positive patients treated Tropical Medicine Foundation Amazonas coloproctology outpatient clinic. METHODS: One hundred ninety were consecutively enrolled 2007 and 2008. All underwent cytologic sampling perform conventional GluCyte (Synermed International, Westfield, Indiana S¸ao Paulo,...
To morphometrically quantify CD1a+ dentritic cells and DC-SIGN+ dendritic in HIV-positive patients with anal squamous intraepithelial neoplasia to evaluate the effects of HIV infection, antiretroviral therapy HPV infection on epithelial subepithelial cells.A prospective study was performed analyze relative volume relationship between cancer from Tropical Medicine Foundation Amazonas, Brazil. All were submitted biopsies anorectal mucosa perform a classic histopathological immunohistochemical...
Background: Combined oral contraceptive (COC) use has been associated with an unfavorable impact on carbohydrate and lipid metabolism in diverse populations of normal-weight obese women. The present study aimed to evaluate the cardiometabolic inflammatory profiles women northeastern Brazil respect COC obesity. Methods: We performed a cross-sectional verify cardiovascular parameters, including blood pressure, fasting serum glucose, profile, population aged 15-45 years, considering obesity...
Soil is a major reservoir of parasite structures and an important vehicle for the spread parasites in population because some helminths protozoa spend stage their life cycle there. From July 2001 to June 2004 3,120 soil samples were collected 18 areas Porto Alegre, RS. The processed by flotation method 40.8% had structures, while 100% public squares contaminated. were: Ascaris spp. (10.2%), eggs Trichuris (4.4%), Toxocara (4.2%), Strongyloidea superfamily (3.4%), protozoan oocysts (16.0%)...
Objetivo: Doença falciforme é um termo utilizado para designar grupo de alterações hereditárias da hemoglobina, causadas por mutação no gene cadeia globina beta; a hemoglobinopatia S pode apresentar-se forma homozigota (HbSS) ou heterozigota com outras variantes, compatíveis fenótipos variados e achados laboratoriais distintos cada genótipo doença falciforme. O objetivo deste estudo foi avaliar diferenças nos parâmetros laboratoriais, perfil socioepidemiológico eventos clínicos em pacientes...
Objetivo: A doença falciforme é uma das desordens genéticas mais prevalentes no Brasil e mundo, sendo caracterizada pela polimerização da hemoglobina S, inflamação crônica pelos mecanismos fisiopatológicos complexos. nefropatia umas principais complicações decorrentes falciforme, com alto risco de evolução para renal (DRC); a microalbuminúria (MALB) um dos achados precoces lesão renal, principalmente em crianças. O objetivo deste estudo foi determinar o perfil (creatinina, ureia...
Objetivo: Pacientes com anemia falciforme sofrem alterações no perfil lipídico que se caracterizam por níveis elevados de triglicérides e colesterol total HDLc baixos. Alterações têm relação eventos vaso-oclusivos nesses indivíduos. O objetivo deste estudo foi estudar as razões triglicérides/HDLc, total/HDLc, LDLc/HDLc sua clínicos uso hidroxiureia em pacientes hemoglobinopatia SC. Método: Foi realizado um corte transversal envolvendo 467 (178 SC 289 falciforme). A determinação do realizada...
Objetivo: A doença falciforme é uma condição genética de herança autossômica recessiva, ampla prevalência mundial, causada pela presença da hemoglobina S em homozigose ou heterozigose com outras hemoglobinopatias. As manifestações clínicas mais frequentes são decorrentes anemia hemolítica crônica e vaso-oclusão. Entre os parâmetros laboratoriais utilizados no acompanhamento clínico, a lactato desidrogenase está associada à síndrome torácica aguda ao risco óbito pacientes falciforme. O...
Objetivo: Contraceptivos orais combinados são utilizados por milhões de mulheres em todo o mundo e, mesmo sendo seguros e eficazes, podem ter impactos negativos no organismo feminino, a depender do tipo concentração estrogênio progestina presentes na sua composição. O objetivo deste estudo foi avaliar perfil cardiometabólico inflamatório usuárias contraceptivos combinados, segundo diferentes formulações. Método: Foram avaliadas 496 com idades entre 15 45 anos, que aceitaram participar...