A5080342823- Hepatitis B Virus Studies
- Parasites and Host Interactions
- Hepatitis C virus research
- Parasite Biology and Host Interactions
- Mosquito-borne diseases and control
- Trypanosoma species research and implications
- Hepatitis Viruses Studies and Epidemiology
- Helminth infection and control
- Viral Infections and Vectors
- Research on Leishmaniasis Studies
- Fecal contamination and water quality
- Viral gastroenteritis research and epidemiology
- Zoonotic diseases and public health
- Pharmaceutical and Antibiotic Environmental Impacts
- HIV/AIDS drug development and treatment
- Liver Disease Diagnosis and Treatment
- Global Maternal and Child Health
- Malaria Research and Control
- Child Nutrition and Water Access
- Insect symbiosis and bacterial influences
- Amoebic Infections and Treatments
- Parasitic Infections and Diagnostics
- Antibiotic Resistance in Bacteria
- Toxin Mechanisms and Immunotoxins
- Animal Virus Infections Studies
Fundação Oswaldo Cruz
2015-2025
Ministério da Saúde
1996-2025
Faculdades Oswaldo Cruz
2017-2023
Escola Bahiana de Medicina e Saúde Pública
2021
Center for Global Health
2005-2009
Case Western Reserve University
2009
Inserm
2006
Universidade de Brasília
2006
Université Claude Bernard Lyon 1
2006
Centro de Estudos e Pesquisas em Educação, Cultura e Ação Comunitária
2005
Background: The World Health Organization recommends a market-ready, urine-based point-of-care diagnostic test for circulating cathodic antigens (CCA) to determine the prevalence of S. mansoni. This study evaluated performance URINE CCA (SCHISTO) ECO TESTE® (POC-ECO), which is currently available in Brazil. Methods: Residents from eight sites with different estimates provided one urine sample POC-ECO and stool Kato-Katz (KK) Helmintex® (HTX) testing as an egg-detecting reference infection...
Background Human papillomavirus (HPV) causes several cancers that disproportionally affect people living with HIV/AIDS (PLWH) yet there is a paucity of research on interventions to foster HPV vaccine use in this population. We sought evaluate the efficacy web-based, tailored intervention (e-HPV) promote vaccination among PLWH. Methods This randomized controlled trial PLWH aged 18 45 years. Participants were recruited between January and June 2022 into two groups: experimental group (e-HPV),...
A major mosquito-borne viral disease outbreak caused by Zika virus (ZIKV) occurred in Bahia, Brazil, 2015, largely due to transmission the mosquito, Aedes aegypti (L.). Detecting ZIKV field samples of Ae. has proven problematic some locations, suggesting other mosquito species might be contributing spread ZIKV. In this study, several (five) adult albopictus (Skuse) mosquitoes that emerged from a 2015 collection eggs Camaçari, were positive for RNA; however, attempts isolate live not...
In Brazil, hepatitis delta virus (HDV) is only reported in Western Amazonia, where severe cases of acute and chronic HDV have been described. The study area was chosen the States Acre Rondonia most B (HBV)/HDV are reported. From December 2003 to October 2004, 40 HBsAg carriers with anti-HDV IgM were selected. An epidemiologic questionnaire, including demographic clinical/epidemiologic variables filled out. amplification genotyping performed. Genotype I detected 22 patients (55.0%), whereas...
Hepatitis C virus (HCV) infection has been identified as the major cause of chronic liver disease among patients on hemodialysis (HD), despite important reduction in risks obtained by testing candidate blood donors for anti-HCV antibodies and use recombinant erythropoietin to treat anemia. A cross-sectional study was performed estimate prevalence HCV genotypes HD Salvador, Northeastern Brazil. Anti-HCV seroprevalence determined ELISA 1243 from all ten different dialysis centers city....
In general, the prevalence and genotype distribution of hepatitis C virus (HCV) are estimated based on ambulatory clinic or hospital population. present work, a population-based study was conducted to estimate HCV infection in Salvador, Brazil. A total 1308 serum samples were collected from 30 'sentinel areas', determined by ELISA confirmed recombinant immunoblot assay RT-PCR. The overall 1.5% (20/1308). Prevalence greater among those aged 35 years older with more education. Genotype 3 most...
Hepatitis C virus (HCV) is the major infectious disease agent among injecting drug users (IDUs), with seroprevalence ranging from 50-90%. In this paper, serological and virological parameters were investigated 194 IDUs, 94 ex-IDUs 95 non-IDUs that sampled by "snowball" technique in three localities renowned for both intense use trafficking activities Salvador, Brazil. The majority of participants male, but sex mean age differed significantly between IDUs/ex-IDUs (p < 0.05). Anti-HCV...
Due to the persistence of dengue and other arbovirus infections in Brazil, government has stepped up measures combat Aedes aegypti mosquito vector. The responsibilities community endemic disease workers (CEDW) health (CHW) include acting as intermediaries disseminating knowledge community. aim this study was analyze practices control by different social subjects: residents CEDW/CHW. Interviews were held with residents, field mobilization CEDW, CHW two neighborhoods Salvador, Bahia State,...
We used a reverse transcription-polymerase chain reaction (RT-PCR) to obtain the genotypes of circulating hepatitis C virus (HCV) in patients from Gastro-Hepatology Unit city Salvador (Bahia State) northeastern Brazil. Viral RNA was detected 83 (65.4%) 127 anti-HCV seropositive serum samples. Positivity significantly associated with alterations levels aspartate aminotransferase and alanine (P < 0.05). Genotyping HCV performed by RT-PCR using genotype-specific primers core region: 24.1%...
Two populations with differing histories of Schistosoma mansoni and hepatitis C infection were compared directly for severity disease extent comorbidity. Demographic, parasitologic, ultrasound surveys conducted on 2038 Egyptians 2120 Kenyans. Hepatitis B serologies transaminase levels obtained from a subset at each site. Despite significantly lower prevalence intensity infection, had higher severe schistosomal fibrosis than Kenyans (36.8% vs. 4.6%). was 3 times more prevalent among...
Urbanization is increasing across the globe, and diseases once considered rural can now be found in urban areas due to migration of populations from endemic areas, local transmission within city, or a combination factors. We investigated epidemiologic characteristics immigrants natives living neighborhood Salvador, Brazil where there focus Schistosoma mansoni. In cross-sectional study, all inhabitants 3 sections community were interviewed examined. order determine degree parasite...
Background Brazil remains the country in Americas with highest prevalence of schistosomiasis. A combination control efforts and development, however, has sharply reduced its intensity distribution. The acquisition specific schistosome populations may be dependent on host characteristics such as sex, age, geography, work, habits culture. How these other align parasite subpopulations guide approaches to improve control. Methodology cohort more than 90% residents two rural communities...
INTRODUCTION: Biomphalaria glabrata is considered to be responsible for the incidence of schistosomiasis in Brazil. Therefore, surveillance areas where prevalent fundamental public health planning. This study was aimed evaluate B. populations water bodies city Salvador, determine their distribution, estimate prevalence Schistosoma mansoni infections, characterize shed cercariae, and identify transmission foci. METHODS: Malacological surveys were carried out 17 collections from Salvador....
The aim of the present study was to evaluate prevalence HEV, TTV and GBV-C/GBV-C/HGV in patients with acute viral hepatitis A, B non-A-C. We evaluated sera 94 from a sentinel program who had A (N = 40), 42) non-A-C 12); 71 blood donors served as controls. IgM anti-HEV IgG antibodies were detected by enzyme immunoassay using commercial kits. GBV-C/HGV nested PCR; genotyping done sequencing phylogenetic analysis. Anti-HEV 38, 10 17% Four 1 also serum. 21% 31% donors. 9% hepatitis, 10% found...
Human parasites are often distributed in metapopulations, which makes random sampling for genetic epidemiology difficult. The typical approach to Schistosoma mansoni involves laboratory passage obtain individual worms with small sample size and selection bias as a consequence. By contrast, the naturally pooled samples from egg output stool or urine directly represent composition of current populations. To test whether could be used estimate population allele frequencies, DNA cloned was...
Abstract Use of antibiotics inevitably leads to antimicrobial resistance. Selection for resistance occurs primarily within the gut humans and animals as well in environment through natural residual streams soil. We evaluated Gram negative bacteria from a river system rural community Bahia, Brazil. Water was collected Jiquiriçá Brejões rivers piped water supply. Additionally, stools were random sample residents, cows, pigs horses near river. The samples screened resistant ciprofloxacin,...
The objective of the present study was to analyze HCV serological and virological parameters from hemophiliacs in State Bahia. Anti-HCV investigated by ELISA a cohort 268 A/B who were followed-up reference unit for hemotherapy viremia genotypes also determined subset 66 anti-HCV seropositive hemophiliacs. Seroprevalence among 42.2% (95% CI 36.5-48.1) significantly higher (p<0.05) according age > or =10 years, presence factor VIII/IX inhibitory antibodies other infection markers. None less...
Many parasite populations are difficult to sample because they not uniformly distributed between several host species and often easily collected from the living host, thereby limiting size possibly distorting representation of population. For Schistosoma mansoni, we investigated use eggs, in aggregate, stools infected individuals as a simple representative sample. Previously, demonstrated that microsatellite allele frequencies can be accurately estimated pooled DNA cloned S. mansoni adults....
Resistance mutation analogs to nucleos(t)ides have been described in treatment-naïve patients with chronic hepatitis B (CHB), clinical implications. The aim of this study was investigate primary resistance mutations and genotypes circulating naïve B, the Northern Northeastern regions Brazil.We conducted a genotypic characterization virus (HBV) 189 chronically infected HBV.Drug resistance-associated located RT domain P gene (rtHBV) were found 6% from Region. rtA194T, rtL180M + rtM204V,...
The Brazilian public health system (SUS) has provided antiviral drugs for chronic hepatitis B treatment over 10 years, but a monitoring drug‐related resistance mutations is not available. Determine the presence of HBV associated with to nucleos(t)ide analogs among 81 patients infection in Salvador—BA—Brazil. HBV‐DNA was PCR amplified primers deduced from rt domain at P gene, sequence extended 1032 bp (from amino acid 1 344—rt domain). Those sequences were submitted drug database retrieve...
Introduction. Giardia duodenalis is an intestinal protozoan with a high prevalence in children of developing countries. Molecular studies revealed great genetic diversity G. duodenalis, assemblages A and B found mainly humans. Despite its importance, the information on molecular epidemiology human giardiasis still limited Brazil.Objective. To characterize isolates from Salvador, Bahia, Brazil.Materials methods. positive fecal samples were obtained 71 two day care centers 39 users clinical...