A5080712512- Inflammatory Bowel Disease
- Microscopic Colitis
- Chromosomal and Genetic Variations
- Genomics and Phylogenetic Studies
- Genomic variations and chromosomal abnormalities
- Genomics and Chromatin Dynamics
- Prostate Cancer Treatment and Research
- Diagnosis and treatment of tuberculosis
- Psoriasis: Treatment and Pathogenesis
- Prostate Cancer Diagnosis and Treatment
- Wildlife Conservation and Criminology Analyses
- Gothic Literature and Media Analysis
- Helicobacter pylori-related gastroenterology studies
- Crime, Deviance, and Social Control
- Rheumatoid Arthritis Research and Therapies
- IL-33, ST2, and ILC Pathways
- Chronic Lymphocytic Leukemia Research
- Nutritional Studies and Diet
- Music Therapy and Health
- Immunodeficiency and Autoimmune Disorders
- Legal Education and Practice Innovations
- Dermatology and Skin Diseases
- Autoimmune and Inflammatory Disorders
- Criminal Justice and Corrections Analysis
- Pharmacological Effects of Natural Compounds
Anglia Ruskin University
2015-2024
Janssen (United States)
2012-2020
Janssen (Switzerland)
2019
Merrimack College
2007-2017
University of California, Santa Cruz
2012
Duke University
2010-2012
Case Western Reserve University
2005
University School
2005
University of Tennessee at Knoxville
2001
Oak Ridge National Laboratory
2000
Psoriasis is a complex disease with an expanding definition of its pathological features. We sought to expand/refine the psoriasis transcriptome using 85 paired lesional and non-lesional samples from cohort patients moderate-to-severe vulgaris who were not receiving active therapy. This new analysis identified 4,175 probe sets (representing 2,725 unique known genes) as being differentially expressed in lesions compared matched biopsies skin when following criteria applied: >2-fold change...
Structural changes (deletions, insertions, and inversions) between human chimpanzee genomes have likely had a significant impact on lineage-specific evolution because of their potential for dramatic irreversible mutation. The low-quality nature the current genome assembly precludes reliable identification many these differences. To circumvent this, we applied method to optimally map fosmid paired-end sequences against systematically identify sites structural variation > or = 12 kb two...
Centromeres, the sites of spindle attachment during mitosis and meiosis, are located in specific positions human genome, normally coincident with diverse subsets alpha satellite DNA. While there is strong evidence supporting association some subfamilies centromere function, basis for establishing whether a given sequence or not designated functional unknown, attempts to understand role particular features identity have been limited by near repetitive nature sequences. Utilizing broadly...
Retroviral infections of the germline have potential to episodically alter gene function and genome structure during course evolution. Horizontal transmissions between species been proposed, but little evidence exists for such events in human/great ape lineage Based on analysis finished BAC chimpanzee sequence, we characterize a retroviral element (Pan troglodytes endogenous retrovirus 1 [PTERV1]) that has become integrated African great Old World monkey is absent from humans Asian genomes....
Genome rearrangement often produces chromosomes with two centromeres (dicentrics) that are inherently unstable because of bridge formation and breakage during cell division. However, mammalian dicentrics, particularly those in humans, can be quite stable, usually one centromere is functionally silenced. Molecular mechanisms inactivation poorly understood since there few systems to experimentally create dicentric human chromosomes. Here, we describe a culture model enriches for de novo...
ABSTRACT The accurate detection and quantitation of cytokines in serum are important the study disease mechanisms, pathogenesis, treatment. Serum can reflect processes that occurring at cellular or tissue level thus provide a means indirectly monitoring these processes. Multiplex allows simultaneous measurement multiple sample, increasing efficiency measuring while reducing sample volumes required for testing. Two commercially available multiplex platforms were evaluated (Pierce SearchLight...
Indigo naturalis is a Traditional Chinese Medicine (TCM) ingredient long-recognized as therapy for several inflammatory conditions, including psoriasis. However, its mechanism unknown due to lack of knowledge about the responsible chemical entity. We took different approach this challenge by investigating molecular profile treatment and impacted pathways. A randomized, double-blind, placebo-controlled clinical study was conducted using topical monotherapy treat moderate plaque psoriasis in...
Centromeres are sites of chromosomal spindle attachment during mitosis and meiosis. While the sequence basis for centromere identity remains a subject considerable debate, one approach is to examine genomic organization at these active that correlated with epigenetic marks function.We have developed an characterize both satellite non-satellite centromeric sequences missing from current assemblies in complex genomes, using dog genome as example. Combining this reference dataset corresponding...
• The way in which novel genetic variation affects the patterns of phenotypic integration natural populations is addressed here. An experimental study presented variability caused by interpopulation hybridization and consequent reshuffling, as well changes physical environment model system Arabidopsis thaliana (Brassicaceae). Our results show a basic invariance sets covarying traits A. thaliana, with nutrient availability principal factor accounting for major departures from general pattern...
Centromeric regions in many complex eukaryotic species contain highly repetitive satellite DNAs. Despite the diversity of centromeric DNA sequences among species, functional centromeres all studied to date are marked by CENP-A, a centromere-specific histone H3 variant. Although it is well established that families multimeric higher-order alpha conserved at human and great ape chromosomes diverged monomeric found old new world monkey genomes, little known about organization, function,...
Introduction The mainstay of treatment for venous ulceration remains compression therapy. Velcro Wrap devices are being increasingly used in these patients despite limited evidence. This feasibility study aimed to compare standard bandaging the JuxtaCures™ wrap device. Methods A single centre, unblinded RCT compared participants with randomised either device or short stretch bandaging. Participants were followed up 26 weeks. Results 160 screened 40 randomised. 3 and 1 didn’t complete study....
Prostate cancer is the most common in males UK and affects around 105 men for every 100,000. The role of radiotherapy management prostate significantly changed over last few decades with developments brachytherapy, external beam (EBRT), intensity-modulated (IMRT), image-guided (IGRT). One challenging factors treatment localized development acute late genitourinary gastrointestinal toxicities. recent European guidelines suggest that there no consensus regarding timing high-dose rate (HDR)...
Introduction Patients with severe dry eye disease (DED) often have limited treatment options standard non-surgical management focused on the use of artificial tears for lubrication and anti-inflammatory drugs. However, do not address extraordinary complexity human tears. Crudely, its vast constituents is essentially filtered blood. Blood several blood-derived products including autologous serum, been studied as tear substitutes. This study proposes to test whole, fresh, blood obtained from a...
Previous studies suggest that changes in body weight can lead to an increased risk of mortality the general population, although results are controversial. The current study sought investigate this association further using data from UK Biobank.This is a large prospective population-based cohort study. Data were derived Biobank, with initial assessments commencing between 2006 and 2010.Proportional hazard models used assess self-reported change all-cause, cancer cardiovascular mortality....