Dimitris Dikeos
A5001290189- Bipolar Disorder and Treatment
- Sleep and related disorders
- Genetic Associations and Epidemiology
- Sleep and Wakefulness Research
- Genomic variations and chromosomal abnormalities
- Genetics and Neurodevelopmental Disorders
- Child and Adolescent Psychosocial and Emotional Development
- Mental Health Research Topics
- Autism Spectrum Disorder Research
- Genetic Syndromes and Imprinting
- Electroconvulsive Therapy Studies
- Treatment of Major Depression
- Suicide and Self-Harm Studies
- Neurotransmitter Receptor Influence on Behavior
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Tryptophan and brain disorders
- Circadian rhythm and melatonin
- Congenital heart defects research
- Genomics and Rare Diseases
- Schizophrenia research and treatment
- Diet and metabolism studies
- Restless Legs Syndrome Research
- Obstructive Sleep Apnea Research
- GABA and Rice Research
- Neuroendocrine regulation and behavior
National and Kapodistrian University of Athens
2016-2025
Eginition Hospital
2016-2025
Andreas Sygros Hospital
2024
Athens State University
2000-2019
University General Hospital Attikon
2016
Stanford University
2012
University Mental Health Research Institute
1998-2008
Mental Health Research Institute
1998-2007
King's College London
2006
European Union
2006
Objectives Clinical variables were investigated in the ‘treatment resistant depression ( TRD )‐ III ’ sample to replicate earlier findings by European research consortium ‘Group for Study of Resistant Depression’ GSRD ) and enable cross‐sample prediction treatment outcome . Experimental procedures was defined a Montgomery Åsberg Depression Rating Scale MADRS score ≥22 after at least two antidepressive trials. Response decline ≥50% below threshold 22. Logistic regression applied predictors...
Background Despite the increasing interest in cardiac autonomic nervous activity, normal development is not fully understood. The main aim was to determine maturation of different sympathetic‐(SNS) and parasympathetic system (PNS) activity parameters healthy patients aged 0.5 20 years. A second potential sex differences. Methods Results Five studies covering 0.5‐ 20‐year age range provided impedance‐ electrocardiography recordings from which heart rate, PNS‐parameters (eg, respiratory sinus...
Background Dimensional structures are established for many psychiatric diagnoses, but dimensions have not been compared between diagnostic groups. Aims To examine the structure of in psychosis, to analyse their correlations with disease characteristics and assess relative contribution v. diagnosis explaining these characteristics. Method Factor analysis OPCRIT items 191 Maudsley Family Study patients schizophrenia, mood disorders schizoaffective disorder, other psychotic illnesses, followed...
Schizophrenia (SCZ) is a severe, debilitating mental illness which has significant genetic component. The identification of factors related to SCZ been challenging and these remain largely unknown. To evaluate the contribution de novo variants (DNVs) SCZ, we sequenced exomes 53 individuals with sporadic their non-affected parents. We identified 49 DNVs, 18 were predicted alter gene function, including 13 damaging missense mutations, 2 conserved splice site nonsense 1 frameshift deletion....
This European multicenter study aimed to elucidate suicidality in major depressive disorder. Previous surveys suggest a prevalence of disorder ≥50%, but little is known about the association different degrees with socio-demographic, psychosocial, and clinical characteristics.We stratified 1410 patients into 3 categories based on Hamilton Rating Scale for Depression item (suicidality) ratings (0=no suicidality; 1-2=mild/moderate 3-4=severe suicidality). Chi-squared tests, analyses covariance,...
Background Conduct disorder (CD) rarely occurs alone but is typically accompanied by comorbid psychiatric disorders, which complicates the clinical presentation and treatment of affected youths. The aim this study was to investigate sex differences in comorbidity pattern CD systematically explore ‘gender paradox’ ‘delayed‐onset pathway’ hypotheses female CD. Methods As part FemNAT‐CD multisite study, semistructured interviews rating scales were used perform a comprehensive phenotypic...
Differences in development of tolerance and occurrence rebound insomnia have been well established between rapidly slowly eliminated benzodiazepine hypnotics. Based on meta-analytic methodology, this study assesses whether there are such differences among the benzodiazepine-like hypnotics (brotizolam, midazolam, triazolam, zolpidem zopiclone). All sleep laboratory studies these drugs (n = 137) published from 1966 to 1997 were obtained, mainly through a MEDLINE search. Rigorous selection...
Differences in development of tolerance and occurrence rebound insomnia have been well established between rapidly slowly eliminated benzodiazepine hypnotics. Based on meta-analytic methodology, this study assesses whether there are such differences among the benzodiazepine-like hypnotics (brotizolam, midazolam, triazolam, zolpidem zopiclone). All sleep laboratory studies these drugs (n= 137) published from 1966 to 1997 were obtained, mainly through a MEDLINE search. Rigorous selection...
The authors used a genome-wide association study (GWAS) of multiply affected families to investigate the schizophrenia common single-nucleotide polymorphisms (SNPs) and rare copy number variants (CNVs).The family sample included 2,461 individuals from 631 pedigrees (581 in primary European-ancestry analyses). Association was tested for single SNPs genetic pathways. Polygenic scores based on results were predict case-control status Schizophrenia Psychiatric GWAS Consortium (PGC) data set,...
Abstract Theoretical and empirical accounts suggest that adolescence is associated with heightened reward learning impulsivity. Experimental tasks computational models can dissociate from the tendency to initiate actions impulsively (action initiation bias) are thus critical characterise mechanisms drive developmental differences. However, existing work has rarely quantified both ability action initiation, or it relied on small samples. Here, using modelling of a task collected large sample...
Reports of substantial evidence for genetic linkage schizophrenia to chromosome 1q were evaluated by genotyping 16 DNA markers across 107 centimorgans this in a multicenter sample 779 informative pedigrees. No significant was observed such linkage, nor heterogeneity allele sharing among the eight individual samples. Separate analyses European-origin families, recessive models inheritance, and families with larger numbers affected cases also failed produce linkage. If susceptibility genes are...