A5047490111- Migraine and Headache Studies
- Ophthalmology and Eye Disorders
- Trigeminal Neuralgia and Treatments
- Sympathectomy and Hyperhidrosis Treatments
- Circadian rhythm and melatonin
- Olfactory and Sensory Function Studies
- Neurological Complications and Syndromes
- Acute Ischemic Stroke Management
- Nitric Oxide and Endothelin Effects
- Cardiovascular Syncope and Autonomic Disorders
- S100 Proteins and Annexins
- Stroke Rehabilitation and Recovery
- Biochemical effects in animals
- Neurological Disorders and Treatments
- Neuropeptides and Animal Physiology
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Metabolism and Genetic Disorders
- Nuclear Structure and Function
- Blood Coagulation and Thrombosis Mechanisms
- Neurological diseases and metabolism
- Connective Tissue Growth Factor Research
- Respiratory Support and Mechanisms
- Neuroscience of respiration and sleep
- Craniofacial Disorders and Treatments
- Musculoskeletal pain and rehabilitation
Karolinska University Hospital
2012-2024
Karolinska Institutet
2011-2024
United Nations Economic and Social Commission for Asia and the Pacific
2021-2024
University Hospital Carl Gustav Carus
2023
John Wiley & Sons (United States)
2021
Hudson Institute
2021
Foothills Medical Centre
2020
University of Calgary
2020
Shaare Zedek Medical Center
1987
Lev Hasharon Hospital
1957
This study was undertaken to identify susceptibility loci for cluster headache and obtain insights into relevant disease pathways.We carried out a genome-wide association study, where 852 UK 591 Swedish cases were compared with 5,614 1,134 controls, respectively. Following quality control imputation, single variant testing conducted using logistic mixed model each cohort. The 2 cohorts subsequently combined in merged analysis. Downstream analyses, such as gene-set enrichment, functional...
Background The aim of this study was to investigate clinical features a cluster headache cohort in Sweden and construct test new scale for grading severity. Methods Subjects were identified by screening medical records the ICD 10 code G44.0, that is, headache. Five hundred participating research subjects filled questionnaire including personal, demographic aspects. We constructed novel cohort: Cluster Headache Severity Scale, which included number attacks per day, attack period duration....
Cluster headache is considered a male-dominated disorder, but we have previously suggested that female patients may display more severe phenotype. Studies on sex differences in cluster been conflicting; therefore, this study, with the largest validated material at present, gives insights into sex-specific characteristics of disease. The objective study was to describe patient demographics, clinical phenotype, chronobiology, triggers, treatment, and lifestyle Swedish population.Study...
Background Cluster headache is characterized by recurrent unilateral attacks of severe intensity. One the main features in a majority patients striking rhythmicity attacks. The CLOCK ( Circadian Locomotor Output Cycles Kaput) gene encodes transcription factor that serves as basic driving force for circadian rhythm humans and therefore particularly interesting candidate cluster headache. Methods We performed an association study on large Swedish case-control sample (449 677 controls)...
Abstract The trigeminal system is key to the pathophysiology of migraine and cluster headache, two primary headache disorders that share many features. Recently, MER proto-oncogene tyrosine kinase ( MERTK ), a cell surface receptor, was strongly associated with through genetic studies. Further, ligand galectin-3 has been found be elevated in serum patients. In this study, ligands were investigated tissue better understand their potential implication disorders. Immunohistochemistry used map...
Abstract Background Cluster headache is characterized by activation of the trigeminovascular pathway with subsequent pain signalling in meningeal vessels, and inflammation has been suggested to play a role pathophysiology. To further investigate cluster headache, inflammatory markers were analysed patients controls. Methods We performed case–control study, collecting cerebrospinal fluid serum samples from healthy controls, remission, active bout, during an attack cover dynamic range...
Migraine and Cluster Headache (CH) are two primary headaches with severe disease burden. The expression the mechanisms involved poorly known. In some attacks of migraine in most CH, there is a release vasoactive intestinal peptide (VIP) originating from parasympathetic cranial ganglia such as sphenopalatine ganglion (SPG). Patients suffering these diseases often deprived effective drugs. aim study was to examine localization botulinum toxin receptor element synaptic vesicle glycoprotein 2A...
Cluster headache (CH) is a primary disorder which characterized by circadian timing of attacks, usually at nighttime, in around two thirds patients. Patients with CH often report sleep difficulties, though it unknown whether this cause or consequence nightly attacks.In case-control study we have assessed quality participants cluster bout respectively remission, compared to control group neurologically healthy individuals investigate the potential connection between and CH.Fifty 42 controls...
We have genotyped a Swedish cluster headache case-control population for three genetic variants representing the most significant markers identified in recently published genome wide association study on headache. The were two common polymorphisms; rs12668955 ADCYAP1R1 (adenylate cyclase activating polypeptide 1 receptor type 1), rs1006417, an intergenic variant chromosome 14q21 and one rare mutation, rs147564881, MME (membrane metalloendopeptidase). screened 542 patients 581 controls using...
The purpose of this study was to investigate the HCRTR2 gene variants rs3122156, rs2653342, and rs2653349 in a large homogenous Swedish case-control cohort order further evaluate possible contribution cluster headache.Cluster headache is severe neurovascular disorder pathophysiology not yet fully understood. Due striking circadian circannual patterns disease, hypothalamus has been research focus headache. Several studies with many different cohorts from Europe have investigated hypocretin...
Up to 25% of individuals who live with cluster headache (CH), an extremely painful primary disorder, do not adequately respond the first-line treatment, triptans. Studies have indicated that genetic variants can play a role in treatment response. Likewise, differences clinical characteristics give clues mechanisms underlying triptan non-response. Our aim was investigate five previously implicated response and their relation usage our Swedish CH cohort potential distinctions characteristics....
Cluster headache (CH) is a severe neurovascular disorder and an increasing amount of evidence points to genetic contribution this disease. When CH was first described, it observed that alcohol may precipitate attack during the active phase The dehydrogenase 4 (ADH4) gene encodes enzyme which contributes metabolization is, therefore, interesting candidate for CH. Two Italian groups have reported association single nucleotide polymorphism (SNP) rs1126671 located in ADH4 with increased risk...
To estimate the prevalence of cluster headache in working-aged people, compare sickness absence rates and disability pension patients to a matched comparison group, explore associations sociodemographic factors with such rates.Through population-based registers, we identified 3,240 people aged 16-64, living Sweden 2010, who at least once during 2001-2010 received inpatient or specialized outpatient health care (ICD-10 code G44.0) as main diagnosis. A group (n = 16,200), for age, sex, type...
Steinberg A, Sjöstrand C, Sominanda Fogdell-Hahn Nilsson Remahl AIM. Interleukin-2 gene expression in different phases of episodic cluster headache – a pilot study.Acta Neurol Scand: 2011: 124: 130–134.© 2010 John Wiley & Sons A/S. Background The pathophysiology (CH) is still largely unknown. Immunological mechanisms have been suggested to be importance. Aim This study aimed investigate cytokine interleukin-2 (IL-2) as possible marker immune system involvement the CH. Methods Eight patients...
The pathophysiology of cluster headache (CH) is only partly understood. Nitric oxide (NO), a potent vasodilator, has been suggested to be involved, and increased plasma levels nitrite, stable product on NO degradation, have identified in the active period remission. aim our study was investigate role CH by measuring its oxidation products, nitrite nitrate, cerebrospinal fluid (CSF), biological compartment closer supposed focus disorder. We collected CSF from 14 episodic patients. Lumbar...
Background Cluster headache is a severe primary disorder commonly featuring strikingly distinct circadian attack pattern. Therefore, the system has been suggested to play crucial role in pathophysiology of cluster headache. Cryptochromes are key components molecular clock generating rhythms and have previously shown be associated with several psychiatric disorders, including seasonal affective disorder, bipolar depression. Methods In this case-control study, we investigated cryptochrome (...
Background.—Cluster headache (CH) is a primary neurovascular disorder characterized by attacks of excruciating pain accompanied ipsilateral autonomic symptoms. CH pathophysiology presumed to involve an activation hypothalamic and trigeminovascular systems, but inflammation immunological mechanisms have also been hypothesized be importance. Objective.—To identify differentially expressed genes during different clinical phases CH, assuming that changes pathophysiological importance would seen...
Cluster headache is a severe primary characterized by extremely painful attacks of unilateral headache. Verapamil commonly used as prophylactic treatment with good effect. In order to search for new pathways involved in the pathophysiology cluster headache, we analyzed genetic variants that were previously linked verapamil response migraine Swedish case-control sample. We TaqMan qPCR screening and performed gene expression analysis on associated genes patient-derived fibroblasts, further...
To determine whether patients with cluster headache have more sickness absence and disability pension days compared to matched references possible associations sociodemographic characteristics.We performed a registry study of all who had received specialized health care for (ICD-10 code G44.0) aged 16-64 years living in Sweden 2010 (n = 3,240; 34% women) from the total population 16,200) regarding their 2010.Mean number was 16.13 (95% confidence interval, 14.05-18.20) among 6.54 (5.97-7.11)...
Cluster headache is a severe disorder with unknown aetiology. The pathophysiology and symptoms present certain common features migraine. Specifically, activation of the trigeminal vascular system seems to be involved in both disorders, which hypothesized result neurogenic inflammation vasodilation cerebral vessels. In addition, genetic factors have been implicated migraine cluster headache. order determine whether or not share risk factors, we screened two variants known increase Sweden...