Margda Wærn

ORCID: 0000-0002-8330-6915
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About
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Research Areas
  • Suicide and Self-Harm Studies
  • Mental Health Treatment and Access
  • Dementia and Cognitive Impairment Research
  • Health disparities and outcomes
  • Psychosomatic Disorders and Their Treatments
  • Schizophrenia research and treatment
  • Alzheimer's disease research and treatments
  • Child and Adolescent Psychosocial and Emotional Development
  • Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Nutritional Studies and Diet
  • Mental Health and Psychiatry
  • Employment and Welfare Studies
  • Maternal Mental Health During Pregnancy and Postpartum
  • Workplace Health and Well-being
  • Substance Abuse Treatment and Outcomes
  • Bipolar Disorder and Treatment
  • Treatment of Major Depression
  • Cardiac Health and Mental Health
  • Mental Health Research Topics
  • Aging and Gerontology Research
  • Homicide, Infanticide, and Child Abuse
  • Diet and metabolism studies
  • Genetic Associations and Epidemiology
  • Grief, Bereavement, and Mental Health
  • Health, Environment, Cognitive Aging

University of Gothenburg
2016-2025

Region Västra Götaland
2019-2025

Sahlgrenska University Hospital
2015-2025

Karolinska Institutet
2001-2024

Stockholm Health Care Services
2022-2024

Umeå University
2022

Tehran University of Medical Sciences
2021

Göteborgs Stads
2020

University College London
2016-2018

National Hospital for Neurology and Neurosurgery
2018

Douglas P. Wightman Iris E. Jansen Jeanne E. Savage Alexey Shadrin Shahram Bahrami and 95 more Dominic Holland Arvid Rongve Sigrid Børte Bendik S. Winsvold Ole Kristian Drange Amy E. Martinsen Anne Heidi Skogholt Cristen J. Willer Geir Bråthen Ingunn Bosnes Jonas B. Nielsen Lars G. Fritsche Laurent F. Thomas Linda M. Pedersen Maiken E. Gabrielsen Marianne Bakke Johnsen Tore Wergeland Meisingset Wei Zhou Petroula Proitsi Angela Hodges Richard Dobson Latha Velayudhan Karl Heilbron Adam Auton Michelle Agee Stella Aslibekyan Elizabeth Babalola Robert K. Bell Jessica Bielenberg Katarzyna Bryc Emily Bullis Briana Cameron Daniella Coker Gabriel Cuéllar-Partida Devika Dhamija Sayantan Das Sarah L. Elson Teresa Filshtein Kipper Fletez‐Brant Pierre Fontanillas Will Freyman Pooja Gandhi Barry Hicks David A. Hinds Karen E. Huber Ethan M. Jewett Yunxuan Jiang Aaron Kleinman Katelyn Kukar Vanessa Lane Keng‐Han Lin Maya Lowe Marie K. Luff Jey C. McCreight Matthew H. McIntyre Kimberly F. McManus Steven J. Micheletti Meghan E. Moreno Joanna L. Mountain Sahar V. Mozaffari Priyanka Nandakumar Elizabeth S. Noblin Jared O’Connell Aaron A. Petrakovitz G. David Poznik Morgan Schumacher Anjali J. Shastri Janie F. Shelton Jingchunzi Shi Suyash Shringarpure Chao Tian Vinh Tran Joyce Y. Tung Xin Wang Wei Wang Catherine H. Weldon Peter Wilton Julia Sealock Lea K. Davis Nancy L. Pedersen Chandra A. Reynolds Ida Karlsson Sigurður H. Magnússon Hreinn Stefánsson Steinunn Þórðardóttir Pálmi V. Jónsson Jón Snædal Anna Zettergren Ingmar Skoog Silke Kern Margda Wærn Henrik Zetterberg Kaj Blennow Eystein Stordal Kristian Hveem

10.1038/s41588-021-00921-z article EN Nature Genetics 2021-09-01

The number of people with dementia has increased dramatically global ageing. Nevertheless, the pathogeneses these diseases are not sufficiently understood. present study aims to analyse relationship between psychological stress in midlife and development late-life. A representative sample females (n = 1462) aged 38–60 years were examined 1968–69 re-examined 1974–75, 1980–81, 1992–93 2000–03. Psychological was rated according a standardized question 1968, 1974 1980. Dementia diagnosed...

10.1093/brain/awq116 article EN Brain 2010-05-20

<h3>Abstract</h3> <b>Objectives:</b> To study the association between physical illness and suicide in elderly people. <b>Design:</b> Case-control with determined from interviews relatives of people who committed control participants medical records. <b>Setting:</b> Gothenburg two surrounding counties (210 703 aged 65 years over). <b>Participants:</b> Consecutive records had undergone forensic examination (46 men, 39 women) living tax register (84 69 women). <b>Main outcome measures:</b>...

10.1136/bmj.324.7350.1355 article EN BMJ 2002-06-08

&lt;i&gt;Background:&lt;/i&gt; Seniors aged 75 and above have the highest suicide rates of all age groups in most industrialized countries. However, research concerning risk factors for old elderly is sparse. &lt;i&gt;Objective:&lt;/i&gt; The purpose was to determine predictors among (75+). Data young (65–74 years) are shown comparison. &lt;i&gt;Methods:&lt;/i&gt; 85 consecutive cases that occurred western Sweden 153 control persons with same sex, birth year, zip code as were randomly...

10.1159/000071715 article EN Gerontology 2003-01-01

OBJECTIVE: The authors’ goal was to study the importance of different psychiatric disorders in relation suicide individuals 65 years old or older. METHOD: psychological autopsy approach used 85 cases among subjects who were older; 153 living comparison from same age group randomly selected tax register interviewed face-to-face. Retrospective axis I diagnoses made according DSM-IV on basis interview data and medical records. RESULTS: Ninety-seven percent victims fulfilled criteria for at...

10.1176/appi.ajp.159.3.450 article EN American Journal of Psychiatry 2002-03-01

Background. Stressful life events, such as family conflicts, separation, bereavement, somatic illness and financial problems are common antecedents of suicide. Studies on suicide among younger persons dominate the literature, despite fact that a large proportion suicides occur elderly persons. Methods. The occurrence stressful events was investigated cases population controls. study conducted in southwestern part Sweden included 85 (46 males 39 females) 65 years above who had committed from...

10.1017/s0033291701004457 article EN Psychological Medicine 2001-10-01

To study secular trends in self reported sexual behaviour among 70 year olds.Cross sectional survey. Settings Four samples representative of the general population Gothenburg, Sweden.1506 adults (946 women, 560 men) examined 1971-2, 1976-7, 1992-3, and 2000-1.Sexual intercourse, attitudes to sexuality later life, dysfunctions, marital satisfaction.From 1971 2000 proportion olds reporting intercourse increased all groups: married men from 52% 68% (P=0.002), women 38% 56% (P=0.001), unmarried...

10.1136/bmj.a279 article EN BMJ 2008-07-08

To study the prevalence of specific sleep disturbances in suicide attempters and to examine association between suicidality. A cross-sectional during period October 1, 2001, June 30, 2004. One hundred sixty-five patients aged 18 68 years who were admitted medical units or psychiatric wards at Sahlgrenska University Hospital after a attempt. N/A The face-to-face interview included Structured Clinical Interview for DSM-IV-IV Suicide Assessment Scale. Two self-report instruments employed,...

10.1093/sleep/30.1.91 article EN SLEEP 2007-01-01

Background Research suggests that suicidal behaviour is aggregated in families. However, due to methodological limitations, including small sample sizes, the strength and pattern of this aggregation remains uncertain. Method We examined familial clustering completed suicide a Swedish total population sample. linked Cause Death Multi-Generation Registers compared rates among relatives all 83 951 decedents from 1952–2003 with those controls. Results Patterns suggested genetic influences on...

10.1017/s0033291711000833 article EN other-oa Psychological Medicine 2011-06-01

Anxiety and depression are more prevalent in women with polycystic ovary syndrome (PCOS) than those without this disorder. Possible confounding effects of overweight obesity suggested. The aim was to compare symptoms anxiety PCOS controls matched for age, body weight mass index (BMI). Women (n = 30) were recruited from the community. Persons ongoing psychotropic medication excluded. All potential participants underwent gynecological examination confirm case–control status. Participants...

10.1093/humrep/dep384 article EN Human Reproduction 2009-11-19

Cellular and animal studies suggest that hypercholesterolemia contributes to Alzheimer disease (AD). However, the relationship between cholesterol dementia at population level is less clear may vary over lifespan.The Prospective Population Study of Women, consisting 1,462 women without aged 38-60 years, was initiated in 1968-1969 Gothenburg, Sweden. Follow-ups were conducted 1974-1975, 1980-1981, 1992-1993, 2000-2001. All-cause diagnosed according DSM-III-R criteria AD National Institute...

10.1212/wnl.0b013e3181feb2bf article EN Neurology 2010-11-11

High midlife and late-life adiposity may increase risk for dementia. Late-life decrease in body mass index (BMI) or weight within several years of a dementia diagnosis has also been reported. Differences study designs analyses provide different pictures this relationship.Thirty-two longitudinal weight, BMI, waist circumference, waist-to-hip ratio (WHR) data, from the Prospective Population Study Women Sweden, were related to A representative sample 1,462 nondemented women was followed 1968...

10.1212/wnl.0b013e3181c0d4b6 article EN Neurology 2009-11-09

Higher midlife blood pressure increases risk for dementia. To further understand the relation between and dementia, it is necessary to examine evolution of from late life. We examined trajectories using linear mixed models in a representative sample middle-aged women (N=1462) who were followed 1968–1969 until 2005–2006 with comprehensive medical neuropsychiatric examinations. Dementia was diagnosed according established criteria. Among those not treated antihypertensives, higher systolic at...

10.1161/hypertensionaha.111.182204 article EN Hypertension 2012-02-14

To improve health care for older persons, we need to learn more about ageing, e.g. identify protective factors and early markers diseases. The Gothenburg H70 Birth Cohort Studies (the studies) are multidisciplinary epidemiological studies examining representative birth cohorts of populations in Gothenburg, Sweden. So far, six 70-year-olds have been examined over time, examinations virtually identical between studies. This paper describes the study procedures baseline examination cohort 1944,...

10.1007/s10654-018-0459-8 article EN cc-by European Journal of Epidemiology 2018-11-13

Studies suggest a role for cardiovascular fitness in the prevention of affective disorders.To determine whether at age 18 is associated with future risk serious illness.Population-based Swedish cohort study male conscripts (n = 1 117 292) born 1950-1987 no history mental illness who were followed 3-40 years. Data on conscription linked national hospital registers to calculate depression (requiring in-patient care) and bipolar disorder.In fully adjusted models low was increased (hazard ratios...

10.1192/bjp.bp.111.103416 article EN The British Journal of Psychiatry 2012-06-15

<h3>Objective:</h3> To study the association between midlife neuroticism and extraversion development of late-life dementia long-standing distress in a sample women followed for 38 years. <h3>Methods:</h3> A population-based 800 women, aged to 54 years, was examined 1968, with subsequent examinations 1974, 1980, 1992, 2000, 2005. Neuroticism were assessed using Eysenck Personality Inventory at baseline. Distress measured according standardized question each wave. Dementia diagnosed...

10.1212/wnl.0000000000000907 article EN Neurology 2014-10-02

To determine the prevalence of preclinical Alzheimer disease (AD) according to current classification systems by examining CSF from a representative general population sample 70-year-olds Gothenburg, Sweden.The was derived population-based H70 Gothenburg Birth Cohort Studies in Sweden. The participants (n = 322, age 70 years) underwent comprehensive neuropsychiatric, cognitive, and somatic examinations. levels β-amyloid (Aβ)42, Aβ40, total tau, phosphorylated tau were measured. Preclinical...

10.1212/wnl.0000000000005476 article EN cc-by Neurology 2018-04-13

To study the relation between body mass index (BMI) in young men and risk of early hospitalization with heart failure.

10.1093/eurheartj/ehw221 article EN other-oa European Heart Journal 2016-06-16
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