A5027351294- Neurotransmitter Receptor Influence on Behavior
- Adipose Tissue and Metabolism
- Cannabis and Cannabinoid Research
- Genetic Associations and Epidemiology
- Coffee research and impacts
- Neuroscience and Neuropharmacology Research
- Adipokines, Inflammation, and Metabolic Diseases
- Nicotinic Acetylcholine Receptors Study
- Dietary Effects on Health
- Obesity, Physical Activity, Diet
- Eating Disorders and Behaviors
- RNA Research and Splicing
- Hormonal and reproductive studies
- Smoking Behavior and Cessation
- MicroRNA in disease regulation
- Attention Deficit Hyperactivity Disorder
- Prenatal Substance Exposure Effects
- Neurogenesis and neuroplasticity mechanisms
- Epigenetics and DNA Methylation
- Bipolar Disorder and Treatment
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Thermoregulation and physiological responses
- Neuroendocrine regulation and behavior
- Exercise and Physiological Responses
Western University
1980-2024
University of Guelph
2019-2023
Princeton University
1980
University of Wisconsin System
1980
Institute of Developmental Physiology
1980
Dalhousie University
1980
Cambridge University Press
1980
Abstract Impulsivity is a multidimensional heritable phenotype that broadly refers to the tendency act prematurely and associated with multiple forms of psychopathology, including substance use disorders. We performed genome-wide association studies (GWAS) eight impulsive personality traits from Barratt Impulsiveness Scale short UPPS-P Impulsive Personality ( N = 123,509–133,517 23andMe research participants European ancestry), measure Drug Experimentation 130,684). Because these GWAS...
Adolescence is an important ontogenetic period that characterized by behaviors such as enhanced novelty-seeking, impulsivity, and reward preference, which can give rise to increased risk for substance use. While use rates in adolescence are generally on a decline, the current combined with emerging trends, increases e-cigarette use, remain significant public health concern. In this review, we focus neurobiological divergences associated adolescent derived from cross-sectional, retrospective,...
Abstract Background Altered lipid metabolism is an important characteristic of neoplastic cells, with androgens and growth factors being major regulatory agents the process. We investigated effect physical resistance training on apoptosis in adult Wistar rat prostate. Methods Two experimental groups represented sedentary training. Three days per week for 13 weeks, rats performed jumps water carrying a weight load strapped to their chests as part exercise protocol. after last session, were...
Ambient cold exposure is often regarded as a promising anti-obesity treatment in mice. However, most preclinical studies aimed at treating obesity via cold-induced thermogenesis have been confounded by subthermoneutral housing temperatures. Therefore, the ability of ambient to combat diet-induced mice housed under humanized thermoneutral conditions currently unknown. Moreover, mammals such are rarely exposed chronic without reprieve, yet subjected experimental rather than intermittent (ICE),...
Co-occurrence of e-cigarette use and alcohol consumption during adolescence is frequent. Here, we examined whether adolescent co-exposure to drinking vaporized nicotine would impact reward- cognition-related behaviors in adult male female rats adulthood.Four groups Sprague Dawley (n = 8-11/group/sex) received either (JUUL 5% pods) or vehicle vapor for 10 minutes daily between postnatal days 30-46, while having continuous voluntary access ethanol water this time a two-bottle preference...
Cannabis is one of the most widely used drugs globally. Decriminalization cannabis further increasing consumption. We performed genome-wide association studies (GWASs) lifetime (N=131,895) and frequency (N=73,374) use. Lifetime use GWAS identified two loci, near CADM2 (rs11922956, p=2.40E-11) another GRM3 (rs12673181, p=6.90E-09). Frequency locus (rs4856591, p=8.10E-09; r2 =0.76 with rs11922956). Both traits were heritable genetically correlated previous GWASs disorder (CUD), as well other...
Abstract The endocannabinoid system (eCBs) encompasses the endocannabinoids, their synthetic and degradative enzymes, cannabinoid (CB) receptors. eCBs mediates inhibition of neurotransmitter release acts as a major homeostatic system. Many aspects are altered in number psychiatric disorders including schizophrenia, which is characterized by dysregulation dopaminergic signaling. GluN1-Knockdown (GluN1KD) Dopamine Transporter Knockout (DATKO) mice models hyperdopaminergia, display abnormal...
Alcohol use is a contributor in the premature deaths of approximately 3 million people annually. Among risk factors for alcohol misuse circadian rhythm disruption; however, this connection remains poorly understood. Inhibition nuclear receptor REV-ERBα known to disrupt molecular feedback loops integral daily oscillations, and impact diurnal fluctuations expression proteins required reward-related neurotransmission. However, role substance use-related phenotypes unknown. Herein, we used...
Abstract Spontaneous recognition memory tasks are widely used to assess cognitive function in rodents and have become commonplace the characterization of rodent models neurodegenerative, neuropsychiatric neurodevelopmental disorders. Leveraging an animal’s innate preference for novelty, these use object exploration capture what, where when components memory. Choosing optimizing objects is a key feature designing tasks. Although range varies extensively across studies, features can bias...
ABSTRACT Impulsivity is a multidimensional heritable phenotype that broadly refers to the tendency act prematurely and associated with multiple forms of psychopathology, including substance use disorders. We performed genome-wide association studies ( GWAS ) eight impulsive personality traits from Barratt Impulsiveness Scale short UPPS-P Impulsive Personality (N=123,509-133,517 23andMe research participants European ancestry), measure Drug Experimentation (N=130,684). Because these...
Recent evidence suggests that aerobic physical training may attenuate the deleterious effects of cancer risk factors, including smoking. We investigated cigarette smoke inhalation and on expression steroid receptors inflammatory apoptotic proteins in prostate. Forty male Wistar rats were distributed four groups: control (CO), exercise (EXE), exposure (CS), with (CS+EXE). For eight weeks, animals repeatedly exposed to for 30 min or performed either without protocol. Following these...
Individuals with schizophrenia frequently experience co-occurring substance use, including tobacco smoking and heavy cannabis use disorders. There is interest in understanding the extent to which these relationships are causal, what shared genetic factors play a role. We explored between (Scz; European ancestry N = 161,405; African 15,846), disorder (CanUD; 886,025; 120,208), ever-regular (Smk; 805,431; 24,278) using largest available genome-wide studies of phenotypes individuals ancestries....
ABSTRACT Introduction Co-occurrence of e-cigarette use and alcohol consumption during adolescence is frequent. However, little known about their long-lasting effects when combined. Here, we examined whether adolescent co-exposure to drinking vapourized nicotine would impact reward- cognition-related behaviours in adult male female rats adulthood. Methods Four groups Sprague Dawley (n=8-11/group/sex) received either (JUUL 5% pods) or vehicle vapour daily between postnatal days 30-46, while...
Proper development of the cerebral cortex relies on asymmetric divisions neural precursor cells (NPCs) to produce a recurring NPC and differentiated neuron. Asymmetric are promoted by differential localization cell-fate determinants, such as mRNA, between daughter cells. Staufen 1 (Stau1) is an RNA-binding protein known localize mRNA in mature hippocampal neurons. Its expression pattern role developing mammalian remains unknown.Both stau1 Stau1 were found be expressed all murine cortex. was...
Abstract Coffee is one of the most widely consumed beverages. We performed a genome-wide association study ( GWAS ) coffee intake in US-based 23andMe participants N =130,153) and identified 7 significant loci, with many replicating three multi-ancestral cohorts. examined genetic correlations phenome-wide across thousands biomarkers health lifestyle traits, then compared our results to largest available from UK Biobank (UKB; =334,659). The these two were highly discrepant. observed positive...
The endocannabinoid system is responsible for regulating a spectrum of physiological activities and plays critical role in the developing brain. During adolescence, particularly sensitive to external insults that may change brain’s developmental trajectory. Cannabinoid receptor type 2 (CB2R) was initially thought predominantly function peripheral nervous system, but more recent studies have implicated its mesolimbic pathway, network largely attributed reward circuitry motivated behavior,...
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