A5019982853- Neural dynamics and brain function
- Visual perception and processing mechanisms
- Neuroscience and Neuropharmacology Research
- Retinal Development and Disorders
- EEG and Brain-Computer Interfaces
- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
- Neurological disorders and treatments
- Neurological Disorders and Treatments
- Chemical Reactions and Isotopes
- Sleep and Wakefulness Research
- Memory and Neural Mechanisms
- Functional Brain Connectivity Studies
- Neuroscience of respiration and sleep
- Biochemical effects in animals
- Ocular and Laser Science Research
- Ophthalmology and Eye Disorders
- Axon Guidance and Neuronal Signaling
- Mitochondrial Function and Pathology
- Vestibular and auditory disorders
- Advanced Differential Geometry Research
- Medical Imaging Techniques and Applications
- Algebraic and Geometric Analysis
- Epilepsy research and treatment
- Color perception and design
German Cancer Research Center
2024
National Center for Tumor Diseases
2024
Heidelberg University
2024
University Hospital Heidelberg
2024
University of California, Los Angeles
1980-2010
UCLA Health
2010
Westwood College
2001-2004
Oklahoma State University Center for Health Sciences
1992
Princeton University
1980
University of Wisconsin System
1980
Electrical microstimulation and unit recording were performed in dorsomedial frontal cortex of four alert monkeys to identify an oculomotor area whose existence had been postulated rostral the supplementary motor area. Contraversive saccades evoked from 129 sites by stimulation. Threshold currents lower than 20 microA half tests. Response latencies usually longer 50 ms (minimum: 30 ms). Eye movements occasionally accompanied blinks, ear, or neck movements. The cortical yielding these was at...
Abstract WGA‐HRP was used to examine projections the brainstem from supplementary eye field (SEF). The SEF defined electrophysiologically in awake, behaving monkeys and connections were compared those of arcuate frontal (FEF), area 6DC, primary motor cortex. found have either direct or indirect with almost every known pre‐ paraoculomotor structure brainstem. project bilaterally layers I IV a tangentially widespread region superior colliculus. Terminal label evident pretectal olivary nucleus,...
The region in and around the thalamic internal medullary lamina (IML) cat recently has been shown to contain neurons active with ocular saccades responding visual stimuli. In present study, single-unit microelectrode recordings were made corresponding of alert monkey order determine whether similar properties existed. Our objective was specify functional characteristics these cells monkey, since 1) cell populations central thalamus form an important link between brain stem structures, such...
In alert monkeys, single-unit responses to visual stimuli were recorded in the central thalamic region where eye movement-related activity has been observed (33). Usually, 1 degree annulus patterns of dim light presented at unpredictable locations on a tangent screen. The animals trained two tasks: one which they delivered stimulus themselves by pressing panel that had release immediately when shape changed square, and another was turned experimenter monkeys rewarded for fixating this target...
Saccades were electrically evoked from the frontal eye field (FEF) of two trained monkeys while saccade-cells recorded intermediate layers superior colliculus (SC). We found that FEF microstimulation, eliciting saccades a given vector, excited SC encoding same vector and inhibited all others. Such mechanism can prevent competing commands arising simultaneously in different structures.
Abstract The supplementary eye field (SEF) was defined electrophysiologically in behaving monkeys to study its connections with the diencephalon and corpus striatum. specificity of SEF pathways determined horseradish peroxidase (HRP) histochemistry compare those arcuate frontal (FEF), contiguous dorsocaudal area 6 (6DC), primary motor cortex (M1, arm/hand region). Results indicate that patterns connectivity were similar FEF markedly different from areas GDC Ml. Primary reciprocal thalamic...
1. Visual responses and eye movement-related activities were studied in single neurons of the thalamic internal medullary lamina (IML) alert cats. The animals faced a tangent screen on which stationary or moving spots light presented. Of 95 units, 26% discharged relation to photic stimuli but not movement, 6% movement stimuli, 68% both. These units intermixed same region. 2. varied from transient sustained. IML found particularly sensitive stimulus when eyes fixed. Strong consistent could be...
Abstract Visual responses and eye movement (EM) ‐related activities were studied in single units of the superior colliculus (SC) alert cats. Spontaneous EMs encouraged by training. Throughout SC (i.e., intermediate deep layers as well superficial layers), found to respond visual stimuli. Strong consistent could be elicited very dim, low‐contrast stationary varied from phasic tonic; some responded tonically stimuli center receptive field, phasically peripheral Many cells more vigorously...
Heterozygous mutations in the TBK1 gene can cause amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The majority of TBK1-ALS/FTD patients carry deleterious loss-of-expression mutations, it is still unclear which function leads to neurodegeneration. We investigated impact pathogenic missense variant p.E696K, does not abolish protein expression, but a selective loss binding autophagy adaptor substrate optineurin. Using organelle-specific proteomics, we found that knock-in...
Schlag, J., P. Dassonville, and M. Schlag-Rey. Interaction of the two frontal eye fields before saccade onset. J. Neurophysiol. 79: 64–72, 1998. A normal environment often contains many objects interest that compete to attract our gaze. Nevertheless, instead initiating a flurry conflicting signals, central populations oculomotor neurons always seem agree on destination next saccade. How is such consensus achieved? In unit recording microstimulation study trained monkeys, we sought elucidate...