A5101430047- Postharvest Quality and Shelf Life Management
- Protein purification and stability
- Plant Physiology and Cultivation Studies
- Suicide and Self-Harm Studies
- Advances in Cucurbitaceae Research
- Plant Molecular Biology Research
- Genetic Associations and Epidemiology
- Chromosomal and Genetic Variations
- Cardiac Imaging and Diagnostics
- Protein Interaction Studies and Fluorescence Analysis
- Plant Virus Research Studies
- Plant Reproductive Biology
- Chemotherapy-induced cardiotoxicity and mitigation
- Electron Spin Resonance Studies
- Connective tissue disorders research
- Plant Surface Properties and Treatments
- Liver Disease Diagnosis and Treatment
- Plant responses to water stress
- Plant Disease Resistance and Genetics
- Vitamin K Research Studies
- Blood properties and coagulation
- Substance Abuse Treatment and Outcomes
- Transgenic Plants and Applications
- Plant Stress Responses and Tolerance
- Bipolar Disorder and Treatment
University of Almería
2018-2022
Baylor College of Medicine
2017-2022
VA Boston Healthcare System
2020-2021
Icahn School of Medicine at Mount Sinai
2020
University of Delaware
2001-2002
Abdominal aortic aneurysm (AAA) is an important cause of cardiovascular mortality; however, its genetic determinants remain incompletely defined. In total, 10 previously identified risk loci explain a small fraction AAA heritability.We performed genome-wide association study in the Million Veteran Program testing ≈18 million DNA sequence variants with (7642 cases and 172 controls) veterans European ancestry independent replication up to 4972 99 858 controls. We then used mendelian...
Abstract Abiotic stresses have a negative effect on crop production, affecting both vegetative and reproductive development. Ethylene plays relevant role in plant response to environmental stresses, but the specific contribution of ethylene biosynthesis signalling components salt stress differs between Arabidopsis rice, two most studied model plants. In this paper, we study three gain-of-function mutations receptors CpETR1B , CpETR1A CpETR2B Cucurbita pepo during germination, seedling...
The Cucurbita pepo genome comprises 263 Mb and 34,240 gene models organized in 20 different chromosomes. To improve our understanding of function we have generated an EMS mutant platform, consisting 3,751 independent M2 families. quality the collection has been evaluated based on phenotyping whole-genome re-sequencing (WGS) results. phenotypic evaluation whole platform at seedling stage demonstrated that rate variation for easily observable traits is more than 10%. percentage families with...
Hypothermia shows promise for stroke neuroprotection, but current cooling strategies cause undesirable side effects that limit their clinical applications. Increasing efforts have focused on pharmacological hypothermia as a treatment option stroke. Previously, we showed activation of thermoregulatory ion channel, transient receptor potential vanilloid 1 (TRPV1), by dihydrocapsaicin (DHC) produces reliable hypothermia. In this study, investigate the TRPV1-mediated DHC long-term ischemic...
A methanesulfonate-generated mutant has been identified in Cucurbita pepo that alters sex determination. The mutation converts female into hermaphrodite flowers and disrupts the growth rate maturation of petals carpels, delaying flower opening, promoting ovaries parthenocarpic development fruit. Whole-genome resequencing allowed identification causal phenotypes as a missense coding region CpACO1A, which encodes for type I ACO enzyme shares high identity with Cucumis sativus CsACO3 melo...
The sexual expression of watermelon plants is the result distribution and occurrence male, female, bisexual hermaphrodite flowers on main secondary stems. Plants can be monoecious (producing male female flowers), andromonoecious or partially flowers) within same plant. Sex determination individual floral buds different flower types plant, are both controlled by ethylene. A single missense mutation in ethylene biosynthesis gene CitACS4, able to promote conversion into flowers, therefore...
Abstract Mutations in the skeletal muscle Ca 2+ release channel, type 1 ryanodine receptor (RYR1), cause malignant hyperthermia susceptibility (MHS) and a life-threatening sensitivity to heat, which is most severe children. Mice with an MHS-associated mutation Ryr1 (Y524S, YS) display lethal contractures response heat. Here we show that heat YS mice exacerbated by brown fat adaptive thermogenesis. In addition, have more adipose tissue thermogenic capacity than their littermate controls....
Abstract Tomato leaf curl New Delhi virus is an emerging whitefly‐borne species of begomovirus in Mediterranean regions that poses a severe threat to cucurbit crops the genus Cucurbita . Until now, only two sources resistance have been identified spp., these being PI604506 (cv. Large Cheese) and PI381814 (Indian landrace), both C. moschata The cv. Cheese conferred by single recessive gene located on chromosome 8. objective present investigation was screen for tomato (ToLCNDV) among 105...
Zucchini is a vegetable fruit that very susceptible to postharvest chilling injury, and ethylene production correlated with injury sensitivity, such the more tolerant cultivar, lower its production. It expected zucchini reduced sensitivity would have higher tolerance. In this study, we compared quality of wild type ethylene-insensitive mutant etr2b, in which mutation was identified coding region receptor gene CpETR2B. Flowers from homozygous WT (wt/wt), plants (etr2b/etr2b) heterozygous...
Abstract Background Cancer therapy-related cardiac dysfunction may occur in pediatric cancer survivors. Identification of early markers myocardial damage secondary to anthracycline exposure is crucial develop strategies that ameliorate this complication. Objectives The purpose study was identify changes induced by doxorubicin with and without cardioprotection using dexrazoxane detected serial magnetic resonance imaging (CMR) a pre-clinical mouse model. Methods Serial CMR examinations were...
Abstract The effective design of affinity ultrafiltration processes using a selective macroligand requires detailed understanding the effects ligand‐binding interactions on product yield and purification. Theoretical calculations were performed to evaluate performance diafiltration separations with both competitive independent binding for impurity. intrinsic selectivity decreased during due increase in fractional impurity as is selectively removed. opposite behavior was seen because strongly...
Of individuals who develop West Nile neuroinvasive disease (WNND), ~10% will die and >40% long-term complications. Current treatment recommendations solely focus on supportive care; therefore, we urgently need to identify novel effective therapeutic options. We observed a correlation between substance P (SP), key player in neuroinflammation, its receptor Neurokinin-1 (NK1R). Our study wild-type BL6 mouse model found that SP is upregulated the brain during infection, which correlated with...
Abstract BackgroundCancer therapy-related cardiac dysfunction may occur in pediatric cancer survivors. Identification of early markers myocardial damage secondary to anthracycline exposure is crucial develop strategies that ameliorate this complication. ObjectivesThe purpose study was identify changes induced by doxorubicin with and without cardioprotection using dexrazoxane detected serial magnetic resonance imaging (CMR) a pre-clinical mouse model.MethodsSerial CMR examinations were...