A5054660916- Viral Infections and Vectors
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Mosquito-borne diseases and control
- COVID-19 Clinical Research Studies
- Neuropeptides and Animal Physiology
- Vitamin K Research Studies
- COVID-19 epidemiological studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Research on Leishmaniasis Studies
- Critical Race Theory in Education
- Higher Education Practises and Engagement
- Appendicitis Diagnosis and Management
- Zoonotic diseases and public health
- Trypanosoma species research and implications
- Child Nutrition and Water Access
- Kawasaki Disease and Coronary Complications
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Vector-borne infectious diseases
- Malaria Research and Control
- COVID-19 Impact on Reproduction
- Critical and Liberation Pedagogy
- Respiratory viral infections research
Texas Children's Hospital
2022-2024
Baylor College of Medicine
2020-2024
Brigham and Women's Hospital
2023
University of London
2023
London School of Hygiene & Tropical Medicine
2023
Harvard University
2023
The University of Queensland
2023
Dana-Farber/Harvard Cancer Center
2023
Ministry of Public Health and Social Assistance
2023
Abstract To assess changes in SARS-CoV-2 spike binding antibody prevalence the Dominican Republic and implications for immunologic protection against variants of concern, we prospectively enrolled 2,300 patients with undifferentiated febrile illnesses a study during March 2021–August 2022. We tested serum samples antibodies nasopharyngeal acute infection using reverse transcription PCR nucleic acid amplification test. Geometric mean titers increased from 6.6 (95% CI 5.1–8.7) units (BAU)/mL...
ABSTRACT. In January 2020, we instituted acute febrile illness surveillance in 11 hospitals and clinics across Belize. Within 3 months, diagnosed an case of Chagas disease by polymerase chain reaction a 7-year-old child the northern part country. Phylogenetic analyses parasite from blood specimen revealed multiclonal Trypanosoma cruzi infection, including parasites TcII (25.0% haplotypes), TcIV (2.5% TcV (72.5% haplotypes) discrete typing units. The family reported no history travel, three...
West Nile virus (WNV) is a neurotropic flavivirus that can cause acute febrile illness leading to neuroinvasive disease. Depression well-described outcome following infection, but the underlying pathogenic mechanisms are unknown. Proinflammatory cytokines play important roles in WNV their role depression post-WNV remains unstudied. This research aimed retrospectively evaluate associations between proinflammatory and new onset cohort. Participants with asymptomatic infection were...
Of individuals who develop West Nile neuroinvasive disease (WNND), ~10% will die and >40% long-term complications. Current treatment recommendations solely focus on supportive care; therefore, we urgently need to identify novel effective therapeutic options. We observed a correlation between substance P (SP), key player in neuroinflammation, its receptor Neurokinin-1 (NK1R). Our study wild-type BL6 mouse model found that SP is upregulated the brain during infection, which correlated with...
Although case reports have suggested an association between severe acute respiratory distress syndrome coronavirus 2 and appendicitis, we found that the overall incidence of appendicitis was stable throughout pandemic at our tertiary pediatric hospital. Furthermore, did not find evidence CoV2 infection in 9 tissues. Therefore, conclude appendix is a common etiologic cause appendicitis.
Abstract The global SARS-CoV-2 immune landscape and population protection against emerging variants is largely unknown. We assessed antibody changes in the Dominican Republic implications for immunological of concern. Between March 2021 August 2022, 2,300 patients with undifferentiated febrile illnesses were prospectively enrolled. Sera was tested total anti-spike antibodies simultaneously collected nasopharyngeal samples acute infection RT-PCR. Geometric mean titers increased from 6.6...
Dengue virus (DENV) is one of the most significant vector-borne pathogens worldwide. In this report, we describe clinical features and laboratory detection dengue in a 45-year-old traveler to Nicaragua on return home United States 2019. Clinical presentation was mild, with rash, headache, fatigue, only low-grade transient fever. Infection dynamics were documented by serology PCR serially collected body fluids. DENV serotype 2 detected whole blood 1 day after symptoms emerged, viral RNA...
Access to water, sanitation, and hygiene (WASH) resources in schools is critical for disease prevention control, especially during public health emergencies. In Belize, systematic, national data on WASH are needed inform decisions interventions. From December 2021 January 2022, a survey was sent electronically government government-aided primary secondary Belize (N = 308) gather information services. the survey, 12 pilot were selected based highest self-reported need participate additional...
COVID-19, caused by the SARS-CoV-2 virus, is a highly pathogenic emerging infectious disease. Healthcare personnel (HCP) are presumably at higher risk of acquiring infections because occupational exposure. The prevalence COVID-19 in HCP unknown, particularly low- to middle-income countries like El Salvador. goal this study was determine seroprevalence anti-SARS-CoV-2 antibodies among Salvador just prior vaccine rollout March 2021. We evaluated 2176 participants from nationally representative...
This research comprises a collaborative auto-ethnographic narrative inquiry study conducted by doctoral student and four undergraduates at university in the Southwest of US over two years – between 2017 2019. The intent this was to uncover ways internalised racism influenced researchers their earliest socialisation years. authors' interest anti-racism provided impetus co-create pedagogy discomfort, which may be value teacher educators, as well those who seek do work excavating deeply-rooted...
Background: Typhus group Rickettsia (TGR) are a subgroup of vector-borne bacterial pathogens in the genus Rickettsia. Flea-borne TGR rickettsiosis humans is most often caused by R. typhi. Clinical disease characteristically presents as fever, rash, headache, nausea, and vomiting, making it difficult to distinguish clinically from other flu-like syndromes. If left untreated or with delayed treatment, severe life-threatening can develop. growing public health concern Texas, where surveillance...