A5103200584- Autoimmune Neurological Disorders and Treatments
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Genetics and Neurodevelopmental Disorders
- Advanced Database Systems and Queries
- Protease and Inhibitor Mechanisms
- Toxoplasma gondii Research Studies
- Semantic Web and Ontologies
- Neuroscience and Neuropharmacology Research
- Web Data Mining and Analysis
- Peripheral Neuropathies and Disorders
- Kawasaki Disease and Coronary Complications
- Autoimmune and Inflammatory Disorders Research
- Child and Adolescent Health
- Intracranial Aneurysms: Treatment and Complications
- Epigenetics and DNA Methylation
- Obesity, Physical Activity, Diet
- Cellular Mechanics and Interactions
- bioluminescence and chemiluminescence research
- Lysosomal Storage Disorders Research
- Viral-associated cancers and disorders
- Indoor Air Quality and Microbial Exposure
- Metabolomics and Mass Spectrometry Studies
- Advanced Chemical Sensor Technologies
- interferon and immune responses
Duke University
2023-2025
Texas Children's Hospital
2020-2024
Baylor College of Medicine
2020-2024
University of California, San Diego
2015-2023
Dartmouth–Hitchcock Medical Center
2021
Dartmouth College
2015-2019
Huntsman Cancer Institute
2010
University of Utah
2010
Brigham Young University
1998-1999
Basic helix–loop–helix (bHLH) transcription factors recognize the canonical E-box (CANNTG) to regulate gene transcription; however, given prevalence of E-boxes in a genome, it has been puzzling how individual bHLH proteins selectively sequences on their targets. TWIST is factor that promotes epithelial–mesenchymal transition (EMT) during development and tumor metastasis. High-resolution mapping occupancy human Drosophila genomes reveals TWIST, but not other proteins, recognizes unique double...
Growth factor signaling drives increased glucose uptake and glycolysis-the Warburg effect-that supports macromolecular synthesis necessary for cell growth proliferation. Thioredoxin interacting protein (TXNIP), a direct glucose-induced transcriptional target of MondoA, is potent negative regulator utilization. Thus, TXNIP may inhibit by restricting substrate availability synthesis. To determine TXNIP's contribution to metabolic reprogramming, we examined MondoA as cells exit quiescence enter...
The cars we drive, the homes live in, restaurants visit, and laboratories offices work in are all a part of modern human habitat. Remarkably, little is known about diversity chemicals present these environments to what degree molecules from our bodies influence built environment that surrounds us vice versa. We therefore set out visualize chemical five habitats together with their occupants, provide snapshot various which humans exposed on daily basis. molecular inventory was obtained...
Maternal immunization confers antibody-mediated protection against neonatal HSV, preventing mortality and long-term behavioral sequelae in a mouse model.
Herpetic stromal keratitis (HSK) is a blinding ocular disease that initiated by HSV-1 and characterized chronic inflammation in the cornea. Although HSK immunopathology of cornea well documented animal models, events preceding this abnormal inflammatory cascade are poorly understood. In study, we have examined activation pathological CD4(+) T cells development HSK. Dendritic cell autophagy (DC-autophagy) an important pathway regulating major histocompatibility complex class II...
While antibody responses to neurovirulent pathogens are critical for clearance, the extent which antibodies access nervous system ameliorate infection is poorly understood. In this study on herpes simplex virus 1 (HSV-1), we demonstrate that HSV-specific present during HSV-1 latency in systems of both mice and humans. We show antibody-secreting cells entered trigeminal ganglion (TG), a key site HSV infection, persisted long after establishment latent infection. also ability passively...
Obesity affected 13.7 million children in the United States 2015. The American Academy of Pediatrics (AAP) offers an evidence-based approach to obesity management, but adherence recommendations is suboptimal. Our objective was improve provider AAP for care patients with by making systematic changes our practice ages > 2 and younger than 19 years a BMI 95th percentile.We performed retrospective chart review 417 qualifying encounters assess six months preceding initiative. We measured as...
During metastasis, tumor cells invade through the basement membrane and intravasate into blood vessels then extravasate distant organs to establish metastases. Here, we report a critical role of transmembrane serine protease fibroblast activation protein (FAP) in metastasis. Expression FAP TWIST1, metastasis driver, is significantly correlated several types human carcinomas, required for TWIST1-induced breast cancer lung. Mechanistically, localized at invadopodia invadopodia-mediated...
X-linked lymphoproliferative disease (XLP1) is a rare primary immunodeficiency characterized by EBV-triggered immune dysregulation, lymphoproliferation, dysgammaglobulinemia, and lymphoma. Early childhood mortality from overwhelming inflammation expected in most patients. The only curative therapy hematopoietic stem cell transplant (HSCT); however, whether to perform HSCT on an asymptomatic patient remains debatable. This uncertainty arises because the natural history of XLP1 patients...
Although case reports have suggested an association between severe acute respiratory distress syndrome coronavirus 2 and appendicitis, we found that the overall incidence of appendicitis was stable throughout pandemic at our tertiary pediatric hospital. Furthermore, did not find evidence CoV2 infection in 9 tissues. Therefore, conclude appendix is a common etiologic cause appendicitis.
Anti-N-methyl-d-aspartate receptor autoimmune encephalitis (NMDAR AE) is an antibody-mediated neurological disorder that may be caused by post-herpes simplex virus-1 meningoencephalitis (HSV ME) and ovarian teratomas, although most pediatric cases are idiopathic. We sought to evaluate if other infections precede NMDAR AE conducting a single-center, retrospective, case-control study of 86 presenting Texas Children's Hospital between 2006 2022. HSV ME (HSV-1 HSV-2) was significantly more...
To assess whether initial ancillary tests (brain magnetic resonance imaging-MRI, electroencephalogram-EEG, and/or cerebrospinal fluid-CSF white blood cell count) are abnormal in children with isolated psychiatric symptoms and anti-NMDA receptor encephalitis.
<h3>Objective:</h3> Our objective was to characterize HSV-1 encephalitis seroconversion into the production of anti-NMDAR antibodies. <h3>Background:</h3> Anti-NMDA receptor autoimmune (NMDARAE) is a cell surface CNS disorder that decouples pharmacological action NMDA receptors from their neuronal networks causing seizures, neuropsychiatric symptoms, movement disorders, and autonomic dysfunction. There are few animal models employed as surrogates for clinical entity; most involve passive...