A5101614145- MicroRNA in disease regulation
- Inflammatory mediators and NSAID effects
- Genetic Associations and Epidemiology
- Lipid metabolism and disorders
- Osteoarthritis Treatment and Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Chromatography in Natural Products
- Mechanical Circulatory Support Devices
- Autophagy in Disease and Therapy
- Phytochemical and Pharmacological Studies
- Endoplasmic Reticulum Stress and Disease
- RNA Interference and Gene Delivery
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Synthesis and biological activity
- Genetic and rare skin diseases.
- Transplantation: Methods and Outcomes
- Sympathectomy and Hyperhidrosis Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Hematological disorders and diagnostics
- Atrial Fibrillation Management and Outcomes
- Patient Safety and Medication Errors
- Cancer and Skin Lesions
- Fungal Biology and Applications
- Birth, Development, and Health
- Free Radicals and Antioxidants
Geisinger Health System
2021-2025
Tibetan Traditional Medical College
2023-2024
International Peace Maternity & Child Health Hospital
2013-2023
Shanghai Jiao Tong University
2013-2023
Zhejiang Chinese Medical University
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Huangshan University
2019
Fudan University
2012
Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and identify 100 independently associated risk variants 11 osteoarthritis phenotypes, 52 of which have not been the disease before. We report thumb spine differences in genetic effects between weight-bearing non-weight-bearing joints. sex-specific early age-at-onset loci. integrate functional genomics data from...
Atrial fibrillation (AF) is a rapid supraventricular arrhythmia. However, the pathogenesis of atrial remains controversial. We obtained transcriptome expression profiles GSE41177, GSE115574 and GSE79768 from GEO database. WGCNA was performed, DEGs were screened, PPI network constructed using STRING CTD database used to identify reference score hub genes associated with cardiovascular diseases. Prediction miRNAs performed by TargetScan. DIANA-miRPath v3.0 applied make functional annotation...
Abstract Osteoarthritis is the third most rapidly growing health condition associated with disability, after dementia and diabetes 1 . By 2050, total number of patients osteoarthritis estimated to reach billion worldwide 2 As no disease-modifying treatments exist for osteoarthritis, a better understanding disease aetiopathology urgently needed. Here we perform genome-wide association study meta-analyses across up 489,975 cases 1,472,094 controls, establishing 962 independent associations,...
A considerable number of pregnant women who were supplemented with folate and vitamin B12 selected as major participants in studying the one-carbon metabolic (OCM) pathway. Our study aimed to explore effects OCM-related indicators on pregnancy-induced hypertension (PIH) preeclampsia (PE) supplementation.A total 1,178 took multivitamin tablets containing 800 μg 4 daily from 3 months before pregnancy after enrolled this study. These classified into three groups: normotensive group (n = 1,006),...
Effective extraction of natural antioxidants from cheap plant sources is still a problem. In this paper, an excellent method ultrasound-assisted phenolic compounds Ajuga ciliata Bunge was studied. The effects four factors including ethanol volume fraction, ultrasonic time, temperature and material liquid ratio were discussed. After single factor experiments had been investigated, 4-factor, 3-level Box-Behnken design experiment used to obtain the model optimum conditions, which are shown as...
HER-2 is a key molecule serving as the therapeutic target, prognostic biomarker, and classification marker in breast cancer. Accurate microRNA profilings had not been conducted purified tumor cells of HER-2-negative HER-2-positive tissue specimens obtained from cancer patients.(i) Differential expression discovery using laser capture microdissection- (LCM-) assisted specimen preparation array chips on overexpressing triple-negative carcinoma (TNBC) subtype tissues, (ii) differential...
Lysosome-associated membrane protein type 2A (LAMP2A) is a key in the chaperone-mediated autophagy (CMA) pathway and has been demonstrated to be involved pathogenesis of number tumors. However, role CMA colorectal cancer cell proliferation, metastasis survival during oxidative stress oxaliplatin resistance remains elucidated. In present study, elevated expression LAMP2A was observed colon tissues. Then, activity increased SW480 HT29 cells with overexpression vector decreased using short...
Eccrine nevus (EN) is a very rare hamartoma of the skin and with varying clinical manifestations. Histologically, these neoplasms present as proliferation normally structured eccrine sweat glands in dermis. There have been no more than 20 cases previously reported English literature. Herein we report 25-year-old man on neck. To our best knowledge, this first case that lesion affecting
Objective To investigate the effect of simvastatin on endothelial cell function in a rat model sepsis. Methods Ninety-six pathogen-free female Wistar rats aged 4 months weighing 200-250 g were randomly divided into 3 groups (n = 32 each): group sham operation (group Ⅰ ); sepsis Ⅱ )and + sepsis(group Ⅲ ) . Sepsis was induced by cecal ligation and puncture (CLP). In 20 mg/kg given via gastric tube once day for 2 weeks. Blood samples taken from carotid artery at 3,6, 24 48 h ( n 8 each time...
Recently, PI3K and HDAC have been considered as promising targets for the cancer therapy. A couple of pan-PI3K/HDAC dual inhibitors developed a new class anticancer agents. Herein, we discovered series (S)-N1-(thiazol-2-yl) pyrrolidine-1,2-dicarboxamide derivatives targeting PI3Kα/HDAC6. All exerted dual-target inhibitory activities. Particularly, in enzymatic selectivity assay, compound 21j was identified subtype-selective PI3Kα/HDAC6 inhibitor (IC50 = 2.9 26 nM against PI3Kα HDAC6,...
Objective To investigate the changes of peritoneal macrophage function in sepsis mice after hyperbaric oxygen (HO) therapy. Methods One hundred C57BL/6 were randomly(random number) divided into four groups equal number (n=25): control group (normal saline), group,hyperbaric group, sepsis+ group; sepstic treated by intra-peritoneal injection with zymosan; The and received therapy (2 atm, 2 h, 100% O2). surviving was obsevred at 72 h percentage M1 detected flow cytometry. expression...
Obliterative bronchiolitis (OB) was a main cause of deterioration long-term prognosis in lung transplant recipients after the first posttransplant year. Proinflammatory cytokine interleukin-18 (IL-18) strengthened both natural immunity and acquired played an important role organ transplantation. The roles IL-18 occurrence, development, drug treatment OB remained unclear. Small interfering RNA (siRNA) against mouse (siRNA-IL-18) used to silence expression. Mouse heterotopic tracheal...