A5032982878- Osteoarthritis Treatment and Mechanisms
- Cancer-related molecular mechanisms research
- Inflammatory mediators and NSAID effects
- Cytokine Signaling Pathways and Interactions
- Genetic Associations and Epidemiology
- RNA Research and Splicing
- Pancreatic function and diabetes
- Immune Response and Inflammation
- Diet, Metabolism, and Disease
- Bioinformatics and Genomic Networks
- Diabetes and associated disorders
- Metabolomics and Mass Spectrometry Studies
- NF-κB Signaling Pathways
- Digestive system and related health
- Cell Adhesion Molecules Research
Technical University of Munich
2021-2025
Helmholtz Zentrum München
2020-2025
Klinikum rechts der Isar
2024-2025
Genomics (United Kingdom)
2024
Multimorbidity is a rising public health challenge with important implications for management and policy. The most common multimorbidity pattern the combination of cardiometabolic osteoarticular diseases. Here, we study genetic underpinning comorbidity between type 2 diabetes osteoarthritis. We find genome-wide correlation two diseases robust evidence association-signal colocalization at 18 genomic regions. integrate multi-omics functional information to resolve colocalizing signals identify...
Osteoarthritis is a complex disease with huge public health burden. Genome-wide association studies (GWAS) have identified hundreds of osteoarthritis-associated sequence variants, but the effector genes underpinning these signals remain largely elusive. Understanding chromosome organisation in three-dimensional (3D) space essential for identifying long-range contacts between distant genomic features (e.g., and regulatory elements), tissue-specific manner. Here, we generate first whole genome...
Abstract Osteoarthritis is a prevalent joint disease and major cause of disability worldwide with no curative therapy. Development disease-modifying therapies requires better understanding the molecular mechanisms underpinning disease. A hallmark osteoarthritis cartilage degradation. To define events characterizing at whole transcriptome level, we performed deep RNA sequencing in paired samples low- high-osteoarthritis grade knee derived from 124 patients undergoing total replacement. We...
Osteoarthritis (OA) is a joint disease featuring cartilage breakdown and chronic pain. Although age trauma are prominently associated with OA occurrence, the trigger signaling pathways propagating their pathogenic aspects ill defined. Following long-term catabolic activity traumatic breakdown, debris accumulates can Toll-like receptors (TLRs). Here we show that TLR2 stimulation suppressed expression of matrix proteins induced an inflammatory phenotype in human chondrocytes. Further, impaired...
Abstract Osteoarthritis is the third most rapidly growing health condition associated with disability, after dementia and diabetes 1 . By 2050, total number of patients osteoarthritis estimated to reach billion worldwide 2 As no disease-modifying treatments exist for osteoarthritis, a better understanding disease aetiopathology urgently needed. Here we perform genome-wide association study meta-analyses across up 489,975 cases 1,472,094 controls, establishing 962 independent associations,...
<h3>Background:</h3> Osteoarthritis (OA) is a complex disease with huge public health burden. Genome-wide association studies (GWAS) have identified hundreds of osteoarthritis-associated DNA sequence variants, but the effector genes underpinning these signals remain largely elusive. Understanding chromosome organization in 3D space essential for identifying long-range contacts between distant genomic features (e.g., and regulatory elements), tissue-specific manner. <h3>Objectives:</h3> Our...
Translational efforts in osteoarthritis are hampered by a gap our understanding of disease processes at the molecular level. Here, we present evidence pronounced transcriptional changes high- and low-disease-grade cartilage tissue, pointing to embryonic involved progression. We identify shared programs between cell populations human fetal limb, increases pre-hypertrophic chondrocytes' low-grade osteoblastic signatures high-grade tissue. find that genetic risk signals enriched six gene...
Osteoarthritis, a whole-joint degenerative disorder, is major public health burden that affects nearly 600 million individuals worldwide. Molecular profiling of relevant tissues crucial for understanding the biological mechanisms underlying disease development. We present first comprehensive map transcriptional regulation disease-relevant primary from knee osteoarthritis patients: macroscopically intact (low-grade, N=263) and degenerated (high-grade, N=216) cartilage, synovium (N=278), fat...
Abstract Multimorbidity is a rising public health challenge with important implications for management and policy. The most common multimorbidity pattern the combination of cardiometabolic osteoarticular diseases. Here, we study genetic underpinning comorbidity between type 2 diabetes osteoarthritis. We find genome-wide correlation two diseases, robust evidence association signal colocalization at 18 genomic regions. integrate multi-omics functional information to resolve colocalizing...