A5023635521- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Congenital Heart Disease Studies
- Lymphoma Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Systemic Lupus Erythematosus Research
- Chromosomal and Genetic Variations
- Preterm Birth and Chorioamnionitis
- Estrogen and related hormone effects
- Acute Lymphoblastic Leukemia research
- Pregnancy and Medication Impact
- Vitamin D Research Studies
- Systemic Sclerosis and Related Diseases
- Vector-Borne Animal Diseases
- Folate and B Vitamins Research
- Health disparities and outcomes
- Chemokine receptors and signaling
- Infant Development and Preterm Care
- Racial and Ethnic Identity Research
- Maternal Mental Health During Pregnancy and Postpartum
- Genetic Associations and Epidemiology
- Vitamin C and Antioxidants Research
- Statistical Methods in Clinical Trials
- Genetic and phenotypic traits in livestock
- Fatty Acid Research and Health
University of California, San Francisco
2018-2020
Cancer Research And Biostatistics
2017-2019
University of California, Berkeley
2005-2009
Berkeley Public Health Division
2009
Harvard University
2005
University of Illinois Urbana-Champaign
1997
Research supports that exposure to stressors (e.g., perceived stress and racism) during pregnancy can negatively impact the immune system, which may lead infection ultimately increases risk for having a preterm or low-birthweight infant. It is well known Black women report higher levels of at multiple timepoints across compared with all other racial ethnic groups. This study addresses gaps in literature by describing pregnant early post-partum women's exposures structural racism...
Population-based case-control studies measuring associations between haplotypes of single nucleotide polymorphisms (SNPs) are increasingly popular, in part because a few "tagging" SNPs may serve as surrogates for variation relatively large sections the genome. Due to current technological limitations, cases and controls must be inferred from unphased genotypic data. Using individual-specific covariates standard epidemiologic analyses (e.g., conditional logistic regression) is an attractive...
<b><i>Background:</i></b> Disparities exist in the rates of preterm birth and infant mortality across different racial/ethnic groups. However, only a few studies have examined impact race/ethnicity on outcomes premature infants. <b><i>Objective:</i></b> To report severe neonatal morbidity among multiple gestational age (GA) groups stratified by race/ethnicity. <b><i>Methods:</i></b> A retrospective cohort study utilizing...
Background Non-Hodgkin lymphoma (NHL) is the fifth most common cancer in U.S. and few causes have been identified. Genetic association studies may help identify environmental risk factors enhance our understanding of disease mechanisms. Methodology/Principal Findings 768 coding haplotype tagging SNPs 146 genes were examined using Illumina GoldenGate technology a large population-based case-control study NHL San Francisco Bay Area (1,292 cases 1,375 controls are included here). Statistical...
Autoimmune rheumatic diseases (ARDs) affect women of childbearing age and have been associated with adverse birth outcomes. The impact like ankylosing spondylitis psoriatic arthritis (PsA) on outcomes remains less studied to date. Our objective was evaluate the ARDs preterm (PTB), congenital anomalies, low weight (LBW) small for gestational (SGA), in a large cohort women.We conducted propensity score-matched analysis predict ARD from retrospective all live, singleton births California...
Abstract Endogenous estrogen exposure is an important determinant of endometrial cancer risk. Aromatase, encoded by CYP19, catalyzes the aromatization androstenedione and testosterone to estrone estradiol, respectively. Several common genetic polymorphisms in CYP19 have been identified, including a TCT insertion/deletion (TTTA) n repeat polymorphism intron IV as well 3′UTR C/T polymorphism. We evaluated these 3 plus additional 9 noncoding individual genotypes predicted haplotypes risk...
Abstract Association studies designed to identify the genetic determinants underlying complex disease increasingly require sustainable high-quality DNA resources for large-scale single-nucleotide polymorphism (SNP) genotyping. Recent have shown that genomic (gDNA) suitable SNP genotyping can be obtained from buccal cells and dried blood spots on Guthrie cards. Further, successful has been done using reaction product of multiple displacement amplification gDNA. We evaluated genotype...
Objective To determine whether maternal cardiovascular disease (CVD) risk factors predict preterm birth. Design Case control. Setting California hospitals. Participants 868 mothers with linked demographic information and biospecimens who delivered singleton births from July 2009 to December 2010. Methods Logistic regression analysis was employed calculate odds ratios for the associations between CVD before during pregnancy (including diabetes, hypertensive disorders cholesterol levels) birth...
Background Infants with critical congenital heart disease ( CCHD ) are more likely to be small for gestational age (GA). It is unclear how this affects mortality. The authors investigated the effect of birth weight Z score on 1-year mortality separately in preterm (GA <37 weeks), early-term 37-38 and full-term 39-42 weeks) infants . Methods Results Live-born GA 22 42 weeks born California 2007-2012 were included analysis. primary predictor was outcome Multivariable logistic regression used....
There is an emerging evidence that pulmonary hypertension associated with amino acid, carnitine, and thyroid hormone aberrations. We aimed to characterize metabolic profiles measured by the newborn screen (NBS) in infants persistent of (PPHN) Nested case–control study from population-based database. Cases were ICD-9 code for PPHN receiving mechanical ventilation. Controls ventilation matched 2:1 gestational age, sex, birth weight, parenteral nutrition administration, age at NBS collection....
Polymorphisms in chemokine genes have been associated with human immunodeficiency virus (HIV)-related non-Hodgkin lymphoma (NHL) but are understudied non-HIV-related NHL. Associations of NHL and subtypes polymorphisms haplotypes CCR5, CCR2, CCL5, CXCL12, CX3CR1 were explored a pooled analysis three case–control studies (San Francisco Bay Area, California; United Kingdom; total: cases N = 1610, controls 1992). Adjusted unconditional logistic regression was used to estimate relative risks...
Abstract Expression of prolactin and estrogen receptors in lymphocytes, bone marrow, lymphoma cell lines suggests that hormonal modulation may influence risk. Prolactin promote the proliferation survival B cells, factors increase non-Hodgkin risk, effects be modified by catechol-O-methyltransferase (COMT), an enzyme alters estrogenic activity. Cytochrome P450 17A1 (CYP17A1), a key biosynthesis, has been associated with increased cancer risk affect susceptibility. We studied polymorphisms...
Theiler's murine encephalomyelitis virus (TMEV)-induced demyelination and experimental allergic are the principal immunologically mediated, genetically controlled models of multiple sclerosis. Previous studies using different mapping techniques identified susceptibility loci for both diseases on chromosomes 3, 6, 17. To more precisely map these TMEV relative to each other, linkage analysis microsatellite markers a (BALB/cByJ x DBA/2J) BALB/cByJ backcross population segregating TMEV-induced...
Endogenous oestrogens play a crucial role in endometrial cancer pathogenesis, with most risk factors causing an increase oestrogens. Adipose tissue, where androgens are converted to by the enzyme aromatase, is important source of endogenous oestrogen production postmenopausal woman. The peroxisome proliferator-activated receptor-gamma (PPARγ), key transcriptional regulator adipogenesis, may also regulation aromatase expression adipose tissue. We hypothesized that functional PPARγ Pro12Ala...
The enzyme 5,10-methylenetetrahydrofolate reductase, encoded by MTHFR, catalyzes the reduction of to 5-methyltetrahydrofolate. MTHFR 677 C→T polymorphism results in an amino acid change, Ala→Val. Val allele is associated with decreased activity (1), and may potentially influence carcinogenesis through somatic DNA methylation or uracil misincorporation synthesis repair. Another common non-synonymous 1298 A→C (Glu→Ala) has been lower blood folate higher homocysteine levels some (e.g., 2) but...
<h3>Background</h3> Autoimmune rheumatic diseases (ARDs) often affect women of childbearing age and have been associated with adverse pregnancy outcomes. Most the literature on impact ARDs birth outcomes to date has focused burden common (e.g., rheumatoid arthritis (RA) systemic lupus erythematosus (SLE)) within Caucasian populations. The effect race/ethnicity among is not well understood. Identification groups who are at highest risk may aid in increased prenatal surveillance prevention...
Abstract Maternal lipid profiles are associated with risk for preterm birth (PTB), although the component and effect size inconsistent between studies. It is also unclear whether these associations result of excessive changes in metabolism during pregnancy or genetic variability genes controlling basal metabolism. This study investigates association scores (GRS) four components (high‐density lipoprotein [HDL‐C], low‐density [LDL‐C], triacylglycerols [TAG], total cholesterol [TC]) PTB....