A5027510363- Physical Activity and Health
- Obesity, Physical Activity, Diet
- Cardiovascular Health and Risk Factors
- Nutrition and Health in Aging
- Chemotherapy-induced cardiotoxicity and mitigation
- Health disparities and outcomes
- Cancer Risks and Factors
- Nutritional Studies and Diet
- Cancer survivorship and care
- Health and Wellbeing Research
- Birth, Development, and Health
- Health and Lifestyle Studies
- Estrogen and related hormone effects
- Cardiovascular and exercise physiology
- Metabolism, Diabetes, and Cancer
- Psychological Well-being and Life Satisfaction
- Balance, Gait, and Falls Prevention
- Cancer, Lipids, and Metabolism
- Frailty in Older Adults
- Gestational Diabetes Research and Management
- Injury Epidemiology and Prevention
- Mobile Health and mHealth Applications
- Diet and metabolism studies
- Cancer Treatment and Pharmacology
- Pregnancy and preeclampsia studies
Fred Hutch Cancer Center
2016-2025
Kaiser Permanente
2016-2024
University of Washington
2022-2024
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2015-2023
Cancer Research Center
2015-2022
National Cancer Institute
2022
New York University
2020
VA Puget Sound Health Care System
2016
Brown University
2016
Kaiser Permanente Center for Health Research
2016
Background: Evidence that higher sedentary time is associated with risk for cardiovascular disease (CVD) based mainly on self-reported measures. Few studies have examined whether patterns of are CVD. Methods: Women from the OPACH Study (Objective Physical Activity and Cardiovascular Health; n=5638, aged 63–97 years, mean age 79±7 years) no history myocardial infarction or stroke wore accelerometers 4 to 7 days were followed up 4.9 years CVD events. Average daily bout duration exposures...
To examine cardiovascular disease (CVD) and mortality risk in women with breast cancer (BC) by therapy received relative to without BC.The study population comprised Kaiser Permanente Northern California members. Cases invasive BC diagnosed from 2005 2013 were matched 1:5 controls on birth year race/ethnicity. Cancer treatment, CVD outcomes, covariate data electronic health records. Multivariable Cox proportional hazards models estimated hazard ratios (HRs) 95% CIs of incidence receipt...
The objective of this study was to identify the number people with diabetes from a DataLink developed as part SUPREME-DM (SUrveillance, PREvention, and ManagEment Diabetes Mellitus) project, consortium 11 integrated health systems that use comprehensive EHR data for research.
<h3>Importance</h3> To our knowledge, no studies have examined light physical activity (PA) measured by accelerometry and heart disease in older women. <h3>Objective</h3> investigate whether higher levels of PA were associated with reduced risks coronary (CHD) or cardiovascular (CVD) <h3>Design, Setting, Participants</h3> Prospective cohort study women from baseline (March 2012 to April 2014) through February 28, 2017, for up 4.91 years. The setting was community-dwelling participants the...
We conducted a laboratory-based calibration study to determine relevant cutpoints for hip-worn accelerometer among women ≥ 60 years, considering both type and filtering of counts. Two hundred wore an ActiGraph GT3X + on their hip while performing eight activities. Oxygen uptake was measured using Oxycon portable calorimeter. Accelerometer data were analyzed in 15-second epochs normal low frequency extension (LFE) filters. Receiver operating characteristic (ROC) curve analyses used calculate...
Background— Reproductive factors provide an early window into a woman’s coronary heart disease (CHD) risk; however, their contribution to CHD risk stratification is uncertain. Methods and Results— In the Women’s Health Initiative Observational Study, we constructed Cox proportional hazards models for including age, pregnancy status, number of live births, age at menarche, menstrual irregularity, first birth, stillbirths, miscarriages, infertility ≥1 year, cause, breastfeeding. We next added...
The incidence of cardiometabolic risk factors in breast cancer (BC) survivors has not been well described. Thus, we compared hypertension, diabetes, and dyslipidemia women with without BC.Women invasive BC diagnosed from 2005 to 2013 at Kaiser Permanente Northern California (KPNC) were identified matched 1:5 noncancer controls on birth year, race, ethnicity. Cumulative rates estimated competing overall death. Subdistribution hazard ratios (sHRs) by Fine Gray regression, adjusted for...
Objectives To prospectively examine associations between accelerometer‐measured physical activity ( PA ) and mortality in older women, with an emphasis on light‐intensity . Design Prospective cohort study baseline data collection March 2012 April 2014. Setting Women's Health Initiative the United States. Participants Community‐dwelling women aged 63 to 99 (N = 6,382). Measurements Minutes per day of usual measured using hip‐worn triaxial accelerometers, functioning Short Physical Performance...
Limited evidence exists to inform physical activity (PA) and sedentary behavior guidelines for older people, especially women. Rigorous on the amounts, intensities, movement patterns associated with better health in later life is needed.
Background The relationship between light intensity physical activity ( PA ), which is common in older adults, and cardiovascular disease CVD ) risk factors unclear. This study examined associations of accelerometer‐measured with women different race‐ethnicities. Methods Results Cross‐sectional analyses were conducted 4832 (mean age 78.9 years; 52.5% white, 30.5% black, 17.1% Hispanic) who without known wore triaxial accelerometers a minimum 4 7 days ≥10 hours/d awake wear‐time. Vector...
The effect of obesity on late-age survival in women without disease or disability is unknown.
A better understanding of medically centered outcomes, such as physical function, for older women with multiple chronic conditions is a national public health priority.The prevalence multimorbidity (defined having 2 from list 12) and comorbidity coronary disease (CHD) were calculated 33,386 who enrolled in the Women's Health Initiative since 1993-1998 ≥ 80 years old by mid-September 2012. Associations between CHD on RAND-36 function scores estimated using linear regression models.The this...
Objectives To examine whether moderate to vigorous physical activity (MVPA) measured using accelerometry is associated with incident falls and associations differ according function or history of falls. Design Prospective study baseline data collection from 2012 2014 1 year follow‐up. Setting Women's Health Initiative participants living in the United States. Participants Ambulatory women aged 63 99 (N = 5,545). Measurements Minutes MVPA per day an accelerometer, functional status Short...
We examined associations of sedentary time and accumulation patterns (ie, how is accumulated) with prevalent diabetes in an ethnically diverse cohort older women. Community-dwelling women aged 63–99 (n = 6,116; median age 79) wore ActiGraph GT3X+ accelerometers 24 h/day for up to 7 days from which we derived average daily three measures patterns: breaks time, usual bout duration, alpha. Odds ratios (ORs) 95% confidence intervals (CIs) were estimated using multivariable logistic regression....
As the proportion of population aged 80 and over accelerates, so does value understanding processes aging well. The purposes this article are to: (a) review contemporary theoretical conceptual perspectives on well, (b) describe indicators well that reflect key concepts as assessed in Women's Health Initiative (WHI) (c) characterize status among women older using data obtained from WHI participants at Extension 2 follow-up.Data Lifestyle Questionnaire, which was administered 2011 to 2012...
Aspects of eudaimonic well-being, such as personal growth (PG) and purpose in life (PL), have been highlighted important to older adults' health. We investigated the relationship PG PL with patterns survival age 85 years older.The sample included 8,880 women from Women's Health Initiative cohort who reached by December 1, 2013, for whom data on constructs were available. Women classified into mutually exclusive outcomes: Healthy, Prevalent, Incident, Disabled, Deceased. each assessed using a...
Abstract Background There are limited data on duration of aromatase inhibitor (AI) and cardiovascular disease (CVD) risk in breast cancer (BC) survivors. We examined CVD mortality associated with AI use postmenopausal women early-stage hormone receptor-positive BC. Methods Postmenopausal diagnosed BC (n = 5,853) who used an were included. Cause-specific hazards models estimated hazard ratios (HRs) 95% confidence intervals (CIs) for associations between (short-term: &gt;0 &lt;2 years;...
Abstract Background There are increasing concerns of cardiovascular safety related to endocrine therapy use in women with breast cancer (BC). We examined risk disease (CVD) events and mortality associated postmenopausal early-stage BC. Methods Postmenopausal diagnosed stage I-III hormone receptor-positive BC from 2005 2013 were included (n = 8,495). Women classified as aromatase inhibitor (AI) users, tamoxifen non-users the 12 months after diagnosis. Likelihood ratio tests whether...
To examine differences in all-cause and cause-specific mortality by sexual orientation Veteran status among older women. Data were from the Women's Health Initiative, with demographic characteristics, psychosocial factors, health behaviors assessed at baseline (1993–1998) all available data sources through 2014. Women information on lifetime behavior included analyses ( N = 137,639; 1.4% minority, 2.5% Veteran). The four comparison groups minority Veterans, non-Veterans, heterosexual...
To evaluate the association between currently recommended guidelines and commonly used clinical criteria for body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR) all-cause mortality in frail older women.Longitudinal prospective cohort study.Women's Health Initiative (WHI)-Observational Study.A sample of women aged 65-84 with complete data to characterize frailty third year WHI follow-up (N = 11,070).Frailty phenotype was determined using modified Fried criteria....
To examine whether Veteran status influences (a) women's survival to age 80 years without disease and disability (b) indicators of successful, effective, optimal aging at ages older.
Whether physical activity (PA) and sedentary behavior influence the odds of women living to age 85 years without chronic disease or disability is not well described. Participants Women’s Health Initiative (n = 49,612) were categorized based on health status by years: (i) lived developing major mobility (“healthy”); (ii) developed with disease; (iii) disease, but disability; (iv) died before their 85th birth year. Multinomial logistic regression models that adjusted for covariates such as...
Background: Limited data are available regarding the correlation between questionnaire and device-measured physical activity (PA) sedentary behavior (SB) in older women. Methods: We evaluated these correlations 5,992 women, aged 63 older, who completed Women’s Health Initiative (WHI) Community Healthy Activities Model Program for Seniors (CHAMPS) PA questionnaires CARDIA SB prior to wearing a hip-worn accelerometer 7 consecutive days. Accelerometer-measured total, light, moderate-to-vigorous...