A5080086834- Genetics, Aging, and Longevity in Model Organisms
- FOXO transcription factor regulation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- GDF15 and Related Biomarkers
- Pharmaceutical Economics and Policy
- Health disparities and outcomes
- Dementia and Cognitive Impairment Research
- Birth, Development, and Health
- Medication Adherence and Compliance
- Adipose Tissue and Metabolism
- Health Systems, Economic Evaluations, Quality of Life
- Biomarkers in Disease Mechanisms
- Blood Pressure and Hypertension Studies
- Lipoproteins and Cardiovascular Health
- Dietary Effects on Health
- Nutrition and Health in Aging
- Nutritional Studies and Diet
- Pharmaceutical studies and practices
- Adipokines, Inflammation, and Metabolic Diseases
- Telomeres, Telomerase, and Senescence
- Sodium Intake and Health
- Cardiovascular Health and Risk Factors
- Liver Disease Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Mental Health Research Topics
Kuakini Medical Center
2015-2024
University of Ottawa
2024
University of Hawaiʻi at Mānoa
2000-2023
University of Hawaii System
1996-2023
Deaconess Hospital
2023
Beth Israel Deaconess Medical Center
2023
Pacific Health Research and Education Institute
2006-2020
Portland State University
2020
Oregon Health & Science University
2012-2020
Oregon State University
2020
Human longevity is a complex phenotype with significant familial component, yet little known about its genetic antecedents. Increasing evidence from animal models suggests that the insulin/IGF-1 signaling (IIS) pathway an important, evolutionarily conserved biological influences aging and longevity. However, to date human data have been scarce. Studies hampered by small sample sizes, lack of precise phenotyping, population stratification, among other challenges. Therefore, more precisely...
ContextHealthy survival has no clear phenotypic definition, and little is known about its attributes, particularly in men.ObjectiveTo test whether midlife biological, lifestyle, sociodemographic risk factors are associated with overall exceptional (free of a set major diseases impairments).Design, Setting, ParticipantsProspective cohort study within the Honolulu Heart Program/Honolulu Asia Aging Study. A total 5820 Japanese American middle-aged men (mean age, 54 [range, 45-68] years) free...
To improve and broaden the applicability of performance-based measures function for use in clinical research settings.Cross-sectional repeated-measures study.Research clinic.Population-based sample Japanese Americans without significant functional impairments aged 35 to 55 56 71 (N=203).Performance-based physical function, including range standard tests, newer automated balance strength data on cognitive lifestyle, medical history, activity.Of nonplatform measures, only one-leg stand was...
Objectives To determine the relation between height, FOXO3 genotype and age of death in humans. Methods Observational study 8,003 American men Japanese ancestry from Honolulu Heart Program/Honolulu-Asia Aging Study (HHP/HAAS), a genetically culturally homogeneous cohort followed for over 40 years. A Cox regression model with as time scale, stratified by year birth, was used to estimate effect baseline height on mortality during follow-up. An analysis longevity-associated variants key...
The G allele of the FOXO3 single nucleotide polymorphism (SNP) rs2802292 exhibits a consistently replicated genetic association with longevity in multiple populations worldwide. aims this study were to quantify mortality risk for longevity-associated genotype and discover particular cause(s) death associated older Americans diverse ancestry. It involved 17-year prospective cohort 3584 American men Japanese ancestry from Honolulu Heart Program cohort, followed by replication 1595 white 1056...
Background Many studies have reported an association between a low or lowered blood total cholesterol (TC) level and subsequent nonatherosclerotic disease incidence death. The question of whether TC is true risk factor alternatively consequence occult at the time measurement remains unsettled. To shed new light onto this problem, we analyzed change over 6- year period (from exam 1 in 1965 through 1968 to 3 1971 1974) relation 16-year mortality cohort Japanese American men. Methods Results...
Peripheral vascular disease as measured by the ankle/brachial blood pressure index (ABI) is associated with increased risk of mortality and morbidity. Few sources data on relationship factors to ABI are available for elderly, especially those >80 years age, minority populations. measurements from Honolulu Heart Program's fourth reexamination 3450 ambulatory, elderly Japanese American men indicate that prevalence an abnormal ABI, defined a ratio <0.9, was 13.6%, increasing 8.0% in 71 74...
High density lipoprotein (HDL) cholesterol has been inversely associated with coronary heart disease. Associations stroke are less clear, particularly among the elderly. In this study, authors examined relation between HDL levels and risk of in elderly men. Levels were measured 2,444 Honolulu Heart Program men aged 71–93 years at 1991–1993 examinations. The participants, who free prevalent stroke, disease, cancer baseline, followed to end 1998 for thromboembolic hemorrhagic stroke. While was...
The aim of this study was to investigate the association between anthropometric measurements sarcopenic obesity and all-cause mortality.The included 2309 Japanese-American men ages 71 93 y. Mortality data were available for up 24 y follow-up. Sarcopenic defined by three patterns indexes (body mass index [BMI], percent body fat [%BF] waist circumference [WC]) skeletal muscle estimated measurements.Of participants, 2210 deaths reported during mean follow-up period 11.7 Risk death significantly...
Summary FOXO 3 has been implicated in longevity multiple populations. By DNA sequencing long‐lived individuals, we identified all single nucleotide polymorphisms ( SNP s) and showed 41 were associated with longevity. Thirteen of these had predicted alterations transcription factor binding sites. Those s appeared to be physical contact, via RNA polymerase II chromatin looping, sites the promoter, likely function together as a cis ‐regulatory unit. The exhibited high degree LD Asian...
More than 1 in 4 Medicare beneficiaries with rheumatoid arthritis use high-cost biologic disease-modifying antirheumatic drugs (DMARDs), and spending for these has risen sharply Part D. Our aim was to conduct the first systematic, national investigation of how D plans cover DMARDs determine patients' financial burden under current cost-sharing structures.We performed a cross-sectional analysis plan formularies (n = 2,737) 50 states Washington, DC using January 2013 Centers Medicaid Services...
OBJECTIVE: This study determined the influence of depressive symptoms on subsequent mortality all causes. METHOD: The Honolulu Heart Program, established in 1965, is a prospective, community-based cohort Japanese American men living Hawaii. analysis was based 3,196 aged 71–93 at time fourth examination 1991–1993. Depressive were measured by use an 11-question version Centers for Epidemiologic Studies Depression Scale questionnaire. All-cause data available 6 years follow up. Data analyzed...
Objective: We examined the effects of antiretroviral regimens on blood pressure (BP). Method: This retrospective study systolic and diastolic BP (SBP DBP) measurements among participants a State Hawaii Department Health program from January 1995 to July 2003. The change in during four consecutive 6-month visits was estimated using linear regression interpreted as per year. changes treatment groups were compared untreated controls. Results: Of 1,601 patients identified, 286 met criteria for...
Background and Purpose— Vitamin D deficiency has been reported to contribute the risk of cardiovascular disease, especially stroke. We examined relationship between dietary vitamin intake 34-year incident Methods— The Honolulu Heart Program is a prospective population-based cohort study 8006 Japanese-American men in Hawaii who were 45 68 years old at baseline examination 1965 1968. Dietary was calculated using Nutritionist IV Version 3 software from 24-hour recall. Subjects with prevalent...
Objectives To identify potentially modifiable late‐life biological, lifestyle, and sociodemographic factors associated with overall healthy survival to age 85. Design Prospective longitudinal cohort study 21 years of follow‐up (1991–2012). Setting Hawaii Lifespan Study. Participants American men Japanese ancestry (mean 75.7, range 71–82) without baseline major clinical morbidity functional impairments (N = 1,292). Measurements Overall (free from six chronic diseases physical or cognitive...
This study examines cost sharing for novel second-line diabetes treatment agents under Medicare Part D.
Abstract —The relation between plasma fibrinogen and total cause-specific mortality was investigated in a cohort of 3571 Japanese-American men aged 71 to 93 years during median follow-up 4.4 years. There were 728 deaths, which 37% accounted for by cardiovascular disease 27% cancer. The age-adjusted relative risk (RR) the top quintile (>3.51 g/L) compared with bottom (<2.57 4.3 ( P <0.0001) first year follow-up. RR reduced 1.7 second but remained significantly slightly increased...
<h3>Background</h3> Urinary protein excretion has been linked to coronary heart disease (CHD); the relationship stroke is less clear. We assessed whether urine dipstick screening for predicted and CHD in Honolulu Heart Program cohort. <h3>Methods</h3> Prospective, observational study of 6252 Japanese American men aged 45 68 years. Proteinuria was detected by means during first third examinations. Subjects were classified as having no proteinuria if results negative at both examinations,...
OBJECTIVES: To study white matter lesions (WMLs) and 5‐year cognitive decline in elderly Japanese‐American men. DESIGN: Longitudinal cohort study. SETTING: Population‐based Honolulu, Hawaii. PARTICIPANTS: men aged 74 to 95 from the Honolulu‐Asia Aging Study (HAAS) who were free of prevalent dementia, underwent a protocol brain MRI scan at fifth HAAS examination (1994–1996), returned for testing 5 years later (N=267). MEASUREMENTS: WMLs dichotomized as present (grade 3–9, 38.2%) or absent...
Therapeutic Drug Monitoring in Infliximab Induction and Remission of Immune-Mediated Inflammatory Diseases
We recently reported that protection against coronary artery disease (CAD) mortality is the major contributor to longer life associated with FOXO3 genotype. The present study examined this relation in more detail. performed a 15-year observational of 3,584 older American men Japanese ancestry from Kuakini Honolulu Heart Program cohort and 1,595 White 1,067 Black elderly individuals Health Aging Body Composition study. Multivariate Cox regression models demonstrated carriage...
Abstract The genetic association of FOXO3 genotypes with human longevity is well established, although the mechanism not fully understood. We now report on relationship variant rs2802292 telomere length, telomerase activity, expression, and inflammatory cytokine levels in men women. In agreement earlier work, conferred protection against shortening peripheral blood mononuclear cells from adults aged 55 years older. This was accompanied by higher activity for carriers longevity-associated G...
OBJECTIVE: To examine the predictive value of psychosocial factors as risk for all‐cause mortality. DESIGN: A community‐based longitudinal cohort study: The Honolulu Heart Program. SETTING: Population‐based study conducted in Oahu, Hawaii. PARTICIPANTS: Three thousand four hundred and ninety‐seven men age 71 to 93 were examined followed prospectively mortality an average 6 years. MEASUREMENTS: Psychosocial data obtained using Lubben Social Networks Scale (LSNS). LSNS consists 10 items—family...