A5036308409- Genetics, Aging, and Longevity in Model Organisms
- FOXO transcription factor regulation
- Nutritional Studies and Diet
- Birth, Development, and Health
- Aging and Gerontology Research
- Health disparities and outcomes
- Diet and metabolism studies
- Cardiovascular Disease and Adiposity
- Dementia and Cognitive Impairment Research
- Fatty Acid Research and Health
- Dietary Effects on Health
- Telomeres, Telomerase, and Senescence
- Diabetes, Cardiovascular Risks, and Lipoproteins
- GDF15 and Related Biomarkers
- Cardiovascular Health and Risk Factors
- Adipose Tissue and Metabolism
- Cardiovascular Health and Disease Prevention
- Nutrition and Health in Aging
- Liver Disease Diagnosis and Treatment
- Insurance, Mortality, Demography, Risk Management
- Biomarkers in Disease Mechanisms
- Frailty in Older Adults
- Cardiovascular Function and Risk Factors
- Global Health Care Issues
- Adipokines, Inflammation, and Metabolic Diseases
Kuakini Medical Center
2015-2024
University of Hawaiʻi at Mānoa
2015-2024
University of Hawaii System
2013-2024
The University of Sydney
2024
Pacific Health Research and Education Institute
2005-2023
Honolulu University
2022
Miami University
2021
Shiga University of Medical Science
2009-2020
John A. Hartford Foundation
2014-2019
Okinawa Prefecture
2010-2018
A high body-mass index (BMI, the weight in kilograms divided by square of height meters) is associated with increased mortality from cardiovascular disease and certain cancers, but precise relationship between BMI all-cause remains uncertain.
Human longevity is a complex phenotype with significant familial component, yet little known about its genetic antecedents. Increasing evidence from animal models suggests that the insulin/IGF-1 signaling (IIS) pathway an important, evolutionarily conserved biological influences aging and longevity. However, to date human data have been scarce. Studies hampered by small sample sizes, lack of precise phenotyping, population stratification, among other challenges. Therefore, more precisely...
Abstract : Long‐term caloric restriction (CR) is a robust means of reducing age‐related diseases and extending life span in multiple species, but the effects humans are unknown. The low intake, long expectancy, high prevalence centenarians Okinawa have been used as an argument to support CR hypothesis humans. However, no long‐term, epidemiologic analysis has conducted on traditional dietary patterns, energy balance, potential phenotypes for specific cohort Okinawans who purported had...
Epidemiologic studies of pancreatic cancer risk have reported null or nonsignificant positive associations for obesity, while height been null. Waist and hip circumference evaluated infrequently. A pooled analysis 14 cohort on 846,340 individuals was conducted; 2,135 were diagnosed with during follow-up. Study-specific relative risks (RRs) 95% confidence intervals (CIs) calculated by Cox proportional hazards models, then using a random effects model. Compared to body mass index (BMI) at...
ContextHealthy survival has no clear phenotypic definition, and little is known about its attributes, particularly in men.ObjectiveTo test whether midlife biological, lifestyle, sociodemographic risk factors are associated with overall exceptional (free of a set major diseases impairments).Design, Setting, ParticipantsProspective cohort study within the Honolulu Heart Program/Honolulu Asia Aging Study. A total 5820 Japanese American middle-aged men (mean age, 54 [range, 45-68] years) free...
Okinawa, an isolated island prefecture of Japan, has among the highest prevalence exceptionally long-lived individuals in world; therefore, we hypothesized that, within this population, genes that confer a familial survival advantage might have clustered. We analyzed pedigrees 348 centenarian families with 1142 siblings and compared sibling 1890 Okinawan general population cohort. Both male female experienced approximately half mortality their birth cohort–matched counterparts. This was...
We studied prospectively the midlife handgrip strength, living habits, and parents' longevity as predictors of length life up to becoming a centenarian. The participants were 2,239 men from Honolulu Heart Program/Honolulu–Asia Aging Study who born before end June 1909 took part in baseline physical assessment 1965–1968, when they 56–68 years old. Deaths followed until 2009 for 44 with complete ascertainment. Longevity was categorized centenarian (≥100 years, n = 47), nonagenarian (90–99...
Objectives To determine the relation between height, FOXO3 genotype and age of death in humans. Methods Observational study 8,003 American men Japanese ancestry from Honolulu Heart Program/Honolulu-Asia Aging Study (HHP/HAAS), a genetically culturally homogeneous cohort followed for over 40 years. A Cox regression model with as time scale, stratified by year birth, was used to estimate effect baseline height on mortality during follow-up. An analysis longevity-associated variants key...
Over the course of twentieth century, human life expectancy at birth rose in high-income nations by approximately 30 years, largely driven advances public health and medicine. Mortality reduction was observed initially an early age continued into middle older ages. However, it unclear whether this phenomenon resulting accelerated rise would continue twenty-first century. Here using demographic survivorship metrics from national vital statistics eight countries with longest-lived populations...
The G allele of the FOXO3 single nucleotide polymorphism (SNP) rs2802292 exhibits a consistently replicated genetic association with longevity in multiple populations worldwide. aims this study were to quantify mortality risk for longevity-associated genotype and discover particular cause(s) death associated older Americans diverse ancestry. It involved 17-year prospective cohort 3584 American men Japanese ancestry from Honolulu Heart Program cohort, followed by replication 1595 white 1056...
Arterial stiffness is established as an independent predictor of cardiovascular morbidity and mortality. The objective was to prospectively evaluate association aortic calcification burden with progression arterial in population-based samples healthy middle-aged men from ERA JUMP cohort (Electron-Beam Computed Tomography Risk Factor Assessment Japanese US Men the Post-World War II Birth Cohort). (n=635) aged 40 49 years (207 white American, 45 black 142 241 Japan) were examined at baseline 4...
Decreased adult neurogenesis, or the gradual depletion of neural stem cells in neurogenic niches, is considered a hallmark brain aging. This review provides comprehensive overview intricate relationship between aging, and potential neuroregenerative properties astaxanthin, carotenoid principally extracted from microalga Haematococcus pluvialis. The unique chemical structure astaxanthin enables it to cross blood–brain barrier easily reach brain, where may positively influence neurogenesis....