A5061197527- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Neuroendocrine regulation and behavior
- Memory and Neural Mechanisms
- Cannabis and Cannabinoid Research
- Pharmacological Receptor Mechanisms and Effects
- Nicotinic Acetylcholine Receptors Study
- Stress Responses and Cortisol
- Sleep and Wakefulness Research
- Ion channel regulation and function
- Pain Mechanisms and Treatments
- Attention Deficit Hyperactivity Disorder
- Tryptophan and brain disorders
- Neural and Behavioral Psychology Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Smoking Behavior and Cessation
- Alcohol Consumption and Health Effects
- Regulation of Appetite and Obesity
- Neural dynamics and brain function
- Psychedelics and Drug Studies
- Nitric Oxide and Endothelin Effects
- Treatment of Major Depression
- Adipose Tissue and Metabolism
Amsterdam Neuroscience
2006-2017
Vrije Universiteit Amsterdam
2001-2012
Amsterdam UMC Location Vrije Universiteit Amsterdam
2002-2012
Center for Neurosciences
1998-2012
Erasmus MC
2003
Erasmus University Rotterdam
2003
University of Amsterdam
1987-2001
Graduate School Neurosciences Amsterdam Rotterdam
1996
University Medical Center Utrecht
1994
Utrecht University
1994
Maladaptive impulsivity is a core symptom in various psychiatric disorders. However, there only limited evidence available on whether different measures of represent largely unrelated aspects or unitary construct. In cross-species translational study, thirty rats were trained impulsive choice (delayed reward task) and action (five-choice serial reaction time paradigms. The correlation between those was assessed during baseline performance after pharmacological manipulations with the...
Abstract The present study was designed to evaluate the relationship between reinstatement of drug‐seeking behaviour following long‐term extinction intravenous (i.v.) drug self‐administration (an animal model for craving) and behavioural sensitization. Rats were allowed self‐administer heroin (50 μg/kg per inj., 14 daily sessions), cocaine (500 10 sessions) or saline. Following a 3‐week period, tests performed priming effects amphetamine, on non‐reinforced behaviour. In addition, occurrence...
Repeated treatment with psychostimulant drugs causes long-lasting behavioral sensitization and associated neuroadaptations. Although induced by a single exposure has also been reported, information on the neurochemical consequences of is sparse. Therefore, to evaluate whether evoked repeated pretreatment regimens represent same neurobiological phenomenon, time-dependent expression behavioral, neurochemical, neuroendocrine after amphetamine was investigated in rats. A (5 mg/kg, i.p.) caused...
Alterations in the hippocampal extracellular matrix contribute to cognitive deficits rats exhibiting a chronic depressive-like state after exposure social defeat–induced persistent stress.
Animal studies have shown that nicotine and psychostimulant drugs (amphetamine cocaine) share the property of inducing long-lasting behavioral neurochemical sensitization, which is thought to contribute their addictive properties. Neuroplasticity subserving learning memory mechanisms considered be involved in psychostimulant-induced sensitization addiction behavior. Because nicotinic receptors brain play a role storage drug-related information underlying reinforcement learning, we evaluated...
Abstract Impulsivity and aggression have been suggested to inversely correlate with central serotonin (5‐HT) levels in a trait‐like manner. However, this relationship is far from straightforward. In the present study we addressed effect of lifelong reduced or absent transporter (SERT) function, which associated constitutively increased extracellular 5‐HT levels, on impulsivity aggression. We used unique SERT knockout rats resident–intruder test, five‐choice serial reaction time task reversal...
Abstract Repeated exposure to drugs of abuse causes persistent behavioural sensitization and associated adaptations in striatal neurotransmission, which is thought play an important role certain aspects drug addiction. Remarkably, even a single psychostimulant such as amphetamine or cocaine can be sufficient elicit long‐lasting sensitization. The present study was designed evaluate whether neurochemical also evoked by morphine, opiate abuse. Rats were pretreated once with morphine (2, 10 30...
Abstract The guanidino compound creatine has been shown to occur throughout the brain affecting energy metabolism and mental performance act at central GABA A receptors as a partial agonist. Therefore, we examined possibility that may in fact represent neuromodulator is released an action‐potential dependent manner. To end, studied uptake of [ 3 H]creatine its electrically evoked release from superfused rat slices well endogenously synthesized creatine. was accumulated neocortex Na +...