A5067217629- Axon Guidance and Neuronal Signaling
- Muscle Physiology and Disorders
- Neurogenesis and neuroplasticity mechanisms
- Zebrafish Biomedical Research Applications
- RNA Research and Splicing
- Decision-Making and Behavioral Economics
- Hormonal Regulation and Hypertension
- Opioid Use Disorder Treatment
- Neural and Behavioral Psychology Studies
- Behavioral Health and Interventions
- Veterinary Pharmacology and Anesthesia
- Genetics, Aging, and Longevity in Model Organisms
- Adipose Tissue and Metabolism
- Birth, Development, and Health
- Developmental Biology and Gene Regulation
- Neuroendocrine regulation and behavior
- Pain Mechanisms and Treatments
- Animal testing and alternatives
- Stress Responses and Cortisol
- Cancer-related gene regulation
- Autism Spectrum Disorder Research
- Wnt/β-catenin signaling in development and cancer
- Genetics and Neurodevelopmental Disorders
- Conducting polymers and applications
- Neuroscience and Neuropharmacology Research
Transpharmation (Ireland)
2023-2024
Trinity College Dublin
2017-2024
KU Leuven
2020-2022
Utrecht University
2011-2012
University Medical Center Utrecht
2012
Impaired decision-making is a core problem in several psychiatric disorders including attention-deficit/hyperactivity disorder, schizophrenia, obsessive compulsive mania, drug addiction, eating disorders, and substance abuse as well chronic pain. To ensure progress the understanding of neuropathophysiology these animals models with good construct predictive validity are indispensable. Many human studies aimed at measuring capacities use Iowa Gambling Task, task designed to model every-day...
Sensory processing relies on projections from the thalamus to neocortex being established during development. Information different sensory modalities reaching is segregated into specialized nuclei, whose neurons then send inputs cognate cortical areas through topographically defined axonal connections. Developing thalamocortical axons (TCAs) normally approach cortex by extending subpallium; here, navigation aided distributed guidance cues and discrete cell populations, such as corridor...
Buprenorphine is commonly used as (part of) postoperative analgesic treatment with dosage dependent side-effects such pica behaviour. No strict consensus exists about the optimal dosing interval of buprenorphine, its duration action has been described being in range 6-12 h. In this study, intervals 8 h (thrice-a-day) and 12 (twice-a-day) for buprenorphine a multimodal strategy (concurrent administration non-steroidal anti-inflammatory drug) were compared on food intake, weight (gnawing...
PCDH19 is a transmembrane protein and member of the protocadherin family. It encoded by X-chromosome more than 200 mutations have been linked to neurodevelopmental PCDH-clustering epilepsy (PCDH19-CE) syndrome. A disturbed cell-cell contact that arises when random X-inactivation creates mosaic absence has proposed cause Several studies shown roles for in neuronal proliferation, migration, synapse function, yet most them focused on cortical hippocampal neurons. As can also be caused impaired...
Down Syndrome (DS) Cell Adhesion Molecules (DSCAMs) are transmembrane proteins of the immunoglobulin superfamily. Human DSCAM is located within DS critical region chromosome 21 (duplicated in patients), and mutations or copy-number variations this gene have also been associated to Fragile X syndrome, intellectual disability, autism, bipolar disorder. The paralogue DSCAM-like 1 (DSCAML1) maps 11q23, implicated development Jacobsen Tourette syndromes. Additionally, a spontaneous mouse deletion...
ABSTRACT The severity of brain comorbidities in Duchenne muscular dystrophy (DMD) depends on the mutation position within DMD gene and differential loss distinct dystrophin isoforms (i.e. Dp427, Dp140, Dp71). Comparative studies mouse models with different profiles may help to understand this genotype−phenotype relationship. aim study was (1) compare phenotypes due Dp427 mdx5cv mice those mdx52 mice, which concomitantly lack Dp140; (2) evaluate replicability separate laboratories. We show...
Abstract Background Sensory processing relies on projections from the thalamus to neocortex being established during development. Information different sensory modalities reaching is segregated into specialized nuclei, whose neurons then send inputs cognate cortical areas through topographically defined axonal connections. Developing thalamocortical axons (TCAs) normally approach cortex by extending subpallium; here, navigation aided distributed guidance cues and discrete cell populations,...