A5024523873- Dialysis and Renal Disease Management
- Blood Pressure and Hypertension Studies
- COVID-19 Clinical Research Studies
- Chronic Kidney Disease and Diabetes
- Venous Thromboembolism Diagnosis and Management
- COVID-19 and healthcare impacts
- Thermoregulation and physiological responses
- Health Systems, Economic Evaluations, Quality of Life
- Birth, Development, and Health
- Long-Term Effects of COVID-19
- Renal function and acid-base balance
- Acute Kidney Injury Research
- COVID-19 diagnosis using AI
- Acute Ischemic Stroke Management
- Advanced Glycation End Products research
- Diet and metabolism studies
- Cardiovascular Health and Disease Prevention
- Body Composition Measurement Techniques
- Physical Activity and Health
- Dermatological and COVID-19 studies
- Skin Diseases and Diabetes
- Artificial Intelligence in Healthcare
- Traumatic Brain Injury and Neurovascular Disturbances
- Nutrition and Health in Aging
- Trauma, Hemostasis, Coagulopathy, Resuscitation
Zuyderland Medisch Centrum
2020-2024
Maastricht University Medical Centre
2014-2024
Maastricht University
2013-2020
University Medical Center
2017-2018
Bioqual
2002
<b><i>Background:</i></b> Cerebral small vessel disease is thought to result from endothelial dysfunction. The glycocalyx, lining the endothelium, a major determinant of function. glycocalyx partially accessible flowing red blood cells at its luminal side, called perfused boundary region (PBR). Glycocalyx damage results in increased PBR, which can be measured sublingual microvasculature. We tested whether PBR patients with cerebral disease, i.e. lacunar stroke...
Albuminuria may be a biomarker of generalized ( i.e. , microvascular and macrovascular) endothelial dysfunction. According to this concept, dysfunction the renal microcirculation causes albuminuria by increasing glomerular capillary wall permeability intraglomerular pressure, latter eventually leading dropout (rarefaction) further increases in pressure. However, direct evidence for an association between rarefaction is lacking. Therefore, we examined cross-sectional recruitment capillaries...
Albuminuria is thought to be a biomarker of microvascular and macrovascular endothelial dysfunction. However, direct evidence for an association dysfunction with albuminuria limited. In addition, experimental data suggest stronger in individuals than those without diabetes.We examined cross-sectional associations flicker light-induced retinal arteriolar dilation (n = 2095) heat-induced skin hyperemia 1508) 24-h the population-based, diabetes-enriched Maastricht Study. We used linear...
Physical inactivity in end-stage renal disease (ESRD) patients is associated with increased mortality, and might be related to abnormalities body composition (BC) physical performance. It uncertain what extent starting dialysis influences the effects of ESRD on activity (PA). This study aimed compare PA performance between stage 5 chronic kidney (CKD-5) non-dialysis patients, healthy controls, assess alterations during transition from CKD-5 dialysis, relate BC.For cross-sectional analyses 44...
COVID-19 is an ongoing global pandemic. There urgent need for identification and understanding of clinical laboratory parameters related to progression towards a severe fatal form this illness, often preceded by so-called cytokine-storm syndrome (CSS). Therefore, we explored the hemocytometric characteristics patients in relation deteriorating condition CSS, using Sysmex XN-10 hematology analyzer.From March 1st till May 16th, 2020, all admitted our hospital with respiratory complaints...
Background Chronic kidney disease, which is defined as having a reduced function (estimated glomerular filtration rate (eGFR)) and/or signs of damage (albuminuria), highly prevalent in Western society and associated with adverse health outcomes, such cardiovascular disease. This warrants search for risk factors lower eGFR higher albuminuria. Physical activity sedentary behavior may be factors. Objective To examine associations physical (total, high, low), time patterns (breaks, prolonged...
Background Cardiovascular disease (CVD) related mortality and morbidity are high in end-stage renal (ESRD). The pathophysiology of CVD ESRD may involve non-traditional risk factors, such as accumulation advanced glycation endproducts (AGEs), dicarbonyls, endothelial dysfunction (ED) low-grade inflammation (LGI). However, detailed data on the relation AGEs dicarbonyls with ED LGI limited. Methods We examined cross-sectional Spearman’s rank correlations serum biomarkers 43 individuals chronic...
Prevalent dialysis patients have low scores of health-related quality life (HRQOL) which are associated with increased risk hospitalization and mortality. Also in CKD-5 non-dialysis patients, HRQOL seem to be lower as compared the general population. This study firstly aimed compare between prevalent a cross-sectional analysis assess longitudinal changes over 1 year after initiation. Secondly, correlation physical activity (PA) was explored.Cross-sectional 44 non-dialysis, 29 dialysis, 20...
Abstract Interest in high-sensitivity cardiac troponin I(hs-cTnI) and T(hs-cTnT) has expanded from acute care to cardiovascular disease(CVD) risk stratification. Whether hs-cTnI hs-cTnT are interchangeable the ambulant setting is largely unexplored. Cardiac injury a mechanism that may underlie associations between levels mortality general population. In population-based Maastricht Study, we assessed correlation concordance hs-cTnT. Multiple regression analyses were conducted assess...
Introduction End-stage renal disease (ESRD) strongly associates with cardiovascular (CVD) risk. This risk is not completely mitigated by replacement therapy. Endothelial dysfunction (ED) and low-grade inflammation (LGI) may contribute to the increased CVD However, data on serum biomarkers of ED LGI during transition therapy (dialysis kidney transplantation) are scarce. Methods We compared between 36 controls, 43 participants chronic (CKD) stage 5 non-dialysis (CKD5-ND), 20 CKD hemodialysis...
Chronic kidney disease (CKD) is associated with an increased cardiovascular mortality risk. It is, however, less clear at what point in the course from normal function to CKD association appears. Studying associations of estimated glomerular filtration rate (eGFR) and albuminuria biomarkers (subclinical) cardiac injury a population without substantial may clarify this issue.We examined cross-sectional eGFR urinary albumin excretion (UAE) high-sensitivity troponin (hs-cTn) T, hs-cTnI,...
Depression is common in individuals with chronic kidney disease (CKD). However, data on the association of albuminuria, which together reduced estimated glomerular filtration rate (eGFR) defines CKD, depression are scarce and conflicting. In addition, it not clear when course from normal function to CKD appears.We examined cross-sectional associations albuminuria eGFR depressive symptoms episodes 2872 3083 40- 75-year-old individuals, respectively, who completed baseline survey an ongoing...
Diagnosing concomitant pulmonary embolism (PE) in COVID-19 patients remains challenging. As such, PE may be overlooked. We compared the diagnostic yield of systematic PE-screening based on YEARS-algorithm to clinical gestalt emergency department (ED) with COVID-19.We included all ED who were admitted because between March 2020 and February 2021. Patients already receiving anticoagulant treatment excluded. Up April 7, 2020, decision perform CT-pulmonary angiography (CTPA) was physician's...
Abstract Aims To determine the association of verbal intelligence, a core constituent health literacy, with diabetic complications and walking speed in people Type 2 diabetes. Methods This study was performed 228 diabetes participating Maastricht Study, population‐based cohort study. We examined cross‐sectional associations score on vocabulary test Groningen Intelligence Test with: 1) determinants (HbA 1c , blood pressure lipid level); 2) complications: chronic kidney disease, neuropathic...
End-stage renal disease (ESRD) is strongly associated with cardiovascular (CVD) risk. Advanced glycation endproducts (AGEs) and dicarbonyls, major precursors of AGEs, may contribute to the pathophysiology CVD in ESRD. However, detailed data on courses AGEs dicarbonyls during transition ESRD patients replacement therapy are lacking. We quantified an extensive panel free protein-bound serum [N ∈-(carboxymethyl)lysine (CML), N ∈-(carboxyethyl)lysine (CEL),...
Identifying patients with a possible SARS-CoV-2 infection in the emergency department (ED) is challenging. Symptoms differ, incidence rates vary and test capacity may be limited. As PCR-testing all ED neither feasible nor effective most centres, rapid, objective, low-cost early warning score to triage for developed.
Abstract Background Rapid identification of emergency department (ED) patients with a possible COVID-19 infection is needed. PCR-testing all ED neither feasible nor effective in most centers, therefore rapid, objective, low-cost screening tool to triage necessary. Methods Results from routine lab tests at the Catharina Hospital were collected July 2019 2020 and used statistical model obtain CoLab-score. The score was validated temporally externally three independent centers. CoLab-score...
Abstract Background Interest in prediction models, including machine learning (ML) based on laboratory data has increased tremendously. Uncertainty measurements and predictions such are inherently intertwined. This study developed a framework for assessing the impact of biological analytical variation uncertainty categorical models. Methods Practical application was demonstrated renal function loss (Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI] equation) 31-day mortality...