A5064341399- Glioma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- History and Theory of Mathematics
- Reformation and Early Modern Christianity
- Historical and Literary Studies
- Historical Philosophy and Science
- Modernist Literature and Criticism
- Brain Metastases and Treatment
- Food Supply Chain Traceability
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Single-cell and spatial transcriptomics
- Cultural Studies and Interdisciplinary Research
- Environmental and Ecological Studies
- Comics and Graphic Narratives
- Narrative Theory and Analysis
- American Constitutional Law and Politics
- Humor Studies and Applications
- School Choice and Performance
- Political and Economic history of UK and US
- Geological and Tectonic Studies in Latin America
- Genetic factors in colorectal cancer
- Vascular Anomalies and Treatments
- Diabetes Management and Research
- Ethics in Clinical Research
Memorial Sloan Kettering Cancer Center
2021-2024
Columbia University
2019-2023
Victoria University of Wellington
2021
EBSCO Industries (United States)
2021
University of East Anglia
2017
Pennine Acute Hospitals NHS Trust
2017
University of Oxford
2012
Fulbourn Hospital
2002-2010
University of Edinburgh
1997-1998
University of Toronto
1996-1997
Abstract Background Safe sampling of central nervous system tumor tissue for diagnostic purposes may be difficult if not impossible, especially in pediatric patients, and an unmet need exists to develop less invasive tests. Methods We report our clinical experience with minimally molecular diagnostics using a clinically validated assay sequencing cerebrospinal fluid (CSF) cell-free DNA (cfDNA). All CSF samples were collected as part care, results reported both clinicians patients/families....
Abstract Background The prognosis for Li–Fraumeni syndrome (LFS) patients with medulloblastoma (MB) is poor. Comprehensive clinical data this patient group lacking, challenging the development of novel therapeutic strategies. Here, we present and molecular on a retrospective cohort pediatric LFS MB patients. Methods In multinational, multicenter study, under 21 years class 5 or 4 constitutional TP53 variants were included. mutation status, methylation subgroup, treatment, progression free-...
Until the first quarter of seventeenth century there was a great deal agreement about nature mathematical practice. Mathematicians, as well their patrons and clients, viewed all possible aspects work, both theoretical practical, being included within discipline. Although sciences were fairly recent foreign import to England, which can barely be traced back beyond mid-sixteenth century, by beginning large growing body practitioners with unified view subject's identity. Divisions began appear,...
Leslie Stephen chose his daughter Virginia Woolf as literary heir and trained her extensively in history biography to prepare for a writing career. Traces of Stephen's training can be found throughout Woolf's work but especially criticism. share the same assumptions about nature aims criticism, that place them tradition Sainte-Beuve. Further, focus on set forces describe birth evolution genres: both father say shifting class structures produce dominant historical consciousness this turn...
Abstract BACKGROUND Accurate molecular diagnosis of infiltrating brainstem tumors, including diffuse midline gliomas and IDH mutant astrocytomas, is essential for prognostication optimal therapy. Surgical biopsy the carries risk permanent neurological deficits may yield insufficient or non-diagnostic tissue. We hypothesized that minimally invasive “liquid biopsy” analyzing circulating tumor cell-free DNA (cfDNA) in cerebrospinal fluid (CSF) could represent an alternative diagnostic modality....
(1997). MATHEMATICS AS A TOOL FOR SOCIAL CHANGE: EDUCATIONAL REFORM IN SEVENTEENTH-CENTURY ENGLAND. The Seventeenth Century: Vol. 12, No. 1, pp. 23-36.
John Wallis and Isaac Barrow were key figures in a transitional period the development of mathematics early modern England: their work reveals tension between emerging algebraic techniques more traditional geometric mode thought. Both men among first professional mathematicians England. studied at Cambridge, deciphered Royalist codes for Parliament during Civil War, was one secretaries to Assembly Divines Westminster. He rewarded his support with Savilian Professorship Geometry Oxford. also...
Abstract BACKGROUND Genomic profiling and precision medicine have revolutionized cancer care but are not accessible to all due high costs, insurance issues, limited access testing facilities or qualified personnel. We established a program providing free clinical genomic worldwide (Make-An-IMPACT) report findings from the pediatric CNS tumor cohort. METHODS Following referral from: (1) physician, (2) disease-specific advocacy group, (3) submission of contact information through website,...
Abstract BACKGROUND Diffuse leptomeningeal glioneuronal tumor (DLGNT) presents with nodular disease throughout the neuroaxis and is characterized by presence of KIAA1549::BRAF fusion chromosome arm 1p deletion. Concomitant gain 1q associated poor prognosis. Diagnosis meningeal biopsy often non-diagnostic due to sampling error or yields insufficient material for molecular testing. We hypothesized that analysis cell free DNA (cfDNA) from cerebrospinal fluid (CSF) could represent a superior...
Abstract Next generation sequencing (NGS) of circulating tumor DNA (ctDNA) from cerebrospinal fluid (CSF) offers a minimally invasive approach to identify somatic alterations for individuals with central nervous system (CNS) cancers. Here, we review our ‘real world’ experience using clinically validated, FDA-authorized platform, MSK-IMPACTTM, comprehensively profile ctDNA CSF samples and without documented CNS involvement by cancer (1007 samples, 711 patients). The patient cohort included...
Abstract Next generation sequencing (NGS) of circulating tumor DNA (ctDNA) from cerebrospinal fluid (CSF) offers a minimally invasive approach to identify somatic alterations for individuals with central nervous system (CNS) cancers. Here, we review our ‘real world’ experience using clinically validated, FDA-authorized platform, MSK-IMPACTTM, comprehensively profile ctDNA CSF samples and without documented CNS involvement by cancer (1007 samples, 711 patients). The patient cohort included...
Abstract Diffuse leptomeningeal glioneuronal tumor (DLGNT) presents with nodular disease throughout the neuroaxis. Histology shows variable presence of a low density intraparenchymal lesion containing OLIG2-expressing neoplastic cells. Molecularly, DLGNT is characterized by KIAA1549::BRAF fusion and chromosome arm 1p deletion. Concomitant gain 1q associated poor prognosis. Diagnosis meningeal biopsy often non-diagnostic we hypothesized analysis cell free DNA (cfDNA) from cerebrospinal fluid...
In the first part of this article* it was shown that neither John Wallis nor Isaac Barrow fits precisely into modern or traditional categories commonly used by historians. Yet other kinds tension between tradition and innovation did exist in wider intellectual community early England might have some bearing on state mathematics. We therefore need to explore how opposition ancient expressed seventeenth century. First, there religiously based belief decay nature; supporters regarded methods be...
Abstract Purpose Pediatric central nervous system tumors remain a leading cause of cancer-related death in children and adolescents. Safe sampling tumor tissue for diagnostic purposes may be challenging. Subclinical detection disease prior to clinical or imaging progression provide opportunity earlier intervention ultimately improve overall survival. Additionally, our understanding molecular evolution response therapy remains limited, given the rarity serial tissue. Methods We report...
Abstract Intrinsic brainstem tumors arising in pediatric, adolescent, and young adult patients comprise a spectrum of entities, predominantly diffuse midline gliomas (DMG) IDH mutant astrocytomas. Accurate molecular diagnosis is essential for prognostication optimal therapy. Therapeutic considerations include inclusion (in mutant) or exclusion H3K27M) adjuvant Temozolomide post radiotherapy use targeted therapy (IDH inhibitors). Surgical biopsy, however, associated with increased risk...
Abstract Molecular profiling of circulating tumor DNA (ctDNA) from cerebrospinal fluid (CSF) has the potential to enhance diagnosis, prognosis, and longitudinal monitoring for glioma patients through a minimally invasive approach. We previously detected somatic mutations gliomas in CSF samples using MSK-IMPACT™, 505-gene FDA-authorized next-generation sequencing panel, tumor-derived 50% with high-grade (HGG). To investigate whether we could sensitivity ctDNA biomarker detection, tested...