A5090362881- Oral Health Pathology and Treatment
- Autoimmune Bullous Skin Diseases
- Head and Neck Cancer Studies
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Dental Health and Care Utilization
- Cancer, Hypoxia, and Metabolism
- Oral health in cancer treatment
- Drug-Induced Adverse Reactions
- Extracellular vesicles in disease
- Salivary Gland Tumors Diagnosis and Treatment
- Urticaria and Related Conditions
- Platelet Disorders and Treatments
- NF-κB Signaling Pathways
- Virus-based gene therapy research
- Oral and Maxillofacial Pathology
- Medicinal Plant Extracts Effects
- Cytokine Signaling Pathways and Interactions
- Cutaneous lymphoproliferative disorders research
- PARP inhibition in cancer therapy
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related Molecular Pathways
- Oral and gingival health research
- Colorectal Cancer Treatments and Studies
The Royal Melbourne Hospital
2017-2025
The University of Melbourne
2015-2025
Royal Dental Hospital of Melbourne
2019-2024
Melbourne Health
2023
Victorian Comprehensive Cancer Centre
2020-2021
Weatherford College
2021
The Alfred Hospital
2021
The University of Texas MD Anderson Cancer Center
2020
Royal Marsden Hospital
2009-2014
Institute of Cancer Research
2014
Interest in the association between oral cancer risk and Candida-associated promotion of mucosal dysplasia continues. However, little is known presence amount yeast mouths healthy patients without lesions. The purpose this prospective cross-sectional clinical study was to ascertain prevalence degree carriage Candida cavities a non-cancer population, with reference range parameters affecting environment.Oral rinse samples were collected from sample 203 attending Royal Dental Hospital...
3503 Background: Akt facilitates cell proliferation/survival and is a suspected driver of progression in ST. MK-2206, highly selective non-ATP competitive allosteric Akti, has nM IC 50 broad preclinical antitumor activity. Methods: Safety tolerability MK-2206 administered QOD 28-day cycles (cy) was assessed. Doses evaluated: 30, 60, 90 mg, 75 mg. Main eligibility criteria: ≥18 yo, evaluable advanced ST, ECOG ≤1, HbA1c ≤8% or fasting glucose ≤110% upper limit normal. PK phosphorylated (pAkt)...
Abstract Oral cancer detection is based on biopsy histopathology, however with digital microscopy imaging technology there real potential for rapid multi-site and simultaneous diagnostic analysis. Fifty-nine patients oral mucosal abnormalities were imaged in vivo a confocal laser endomicroscope using the contrast agents acriflavine fluorescein of epithelial dysplasia cancer. To analyse 9168 images frames obtained, three tandem applied pre-trained Inception-V3 convolutional neural network...
ABSTRACT We present a case series of six patients with co‐existing oral pemphigus vulgaris and lichen planus to further characterize the relationship between these two conditions. The findings suggest that represent distinct
Objectives Although we have scientific and policy discussions on the need for oral health care, rarely populations been asked about their expectations regarding this important matter. Therefore, public voice has absent from these discussions. This study aims to quantify support among working-age Australian adults essentiality of care assess whether affordability differs by sociodemographic characteristics. Study type Descriptive analysis nationally representative data Australia. Methods...
Abstract Oral swirls are a noninvasive, rapidly collected source of salivary microRNA (miRNA) potentially useful in the early detection disease states, particularly oral squamous cell carcinoma (OSCC). The aim this study was to predict presence OSCC using panel OSCC-related dysregulated miRNA found swirls, identified jointly data from formalin-fixed paraffin-embedded (FFPE) and fresh-frozen specimens. Next-generation sequencing (NGS) used determine fold changes FFPE specimens relative...
Abstract Background Matrix metalloproteinases (MMPs) play a crucial role in the malignant phenotype of cancer cells. In particular, active levels MMP2 cells have been associated with invasion and metastasis through degradation basement membrane extracellular matrix proteins. However, little is known about this potential biomarker oral cancer. Our aim was to investigate effect inhibition on OSCC activity vitro, as well assess dysregulation samples. Methods Human cell lines H357 H400 were...
Special needs dentistry (SND) is an emerging dental specialty, with ongoing developments in education and clinical practice focused towards the tailored management of individuals special (SN). Patients SN have a higher prevalence oral diseases unmet compared to general population. Although inadequate training experience managing patients has been highlighted as significant barrier accessing care, there limited data about extent SND teaching at entry-to-practice or levels.
Abstract Objectives Special needs dentistry (SND) is a vast and fragmented field of study. This comprehensive bibliometric analysis aimed to evaluate the scope SND, including existing knowledge base, distribution structure, quantitative relationships, research trends. Material Methods A systematic search was conducted on March 10, 2022, using Web Science Core Collection database, covering period from 1985 2021, focusing studies reporting special populations in dentally relevant context....
5005 Background: AA is an oral irreversible inhibitor of CYP17 (17α-hydroxylase/ C17,20-lyase) and androgen synthesis under evaluation for the treatment CRPC pts. Methods: Since 2005 pts who have failed deprivation therapy (ADT) been enrolled into two parallel trials AA: i) Phase I/II study in chemo-naïve ii) II post-docetaxel. Both utilized a two-stage Simon design with Ho 10% Ha 30%, α = 0.05; β 0.1 PSA response (≥50% decline) by PSAWG criteria as primary endpoint evaluation. Results: 86...
The increased glucose uptake observed in cancer cells is mediated by transporters (GLUTs), a class of transmembrane proteins that facilitate the transport and other substrates across plasma membrane. Despite important role pathophysiology oral squamous cell carcinoma (OSCC), there very limited data regarding expression GLUTs normal or malignant from mucosa. We analysed messenger RNA (mRNA) all 14 two OSCC (H357/H400) one non-malignant keratinocyte (OKF6) line using quantitative polymerase...
Machine learning analyses within the realm of oral cancer outcomes are relatively underexplored compared to other types. This study aimed assess performance machine algorithms in identifying patients, utilizing microRNA expression data. In this study, we implemented approach using a panel cancer-associated microRNAs sourced from standard incisional biopsy specimens identify cases squamous cell carcinomas (OSCC). For model development process, used dataset comprising 30 OSCC and...
3009 Background: Akt mediates cell proliferation, survival, and angiogenesis is deregulated in cancer. MK a potent, allosteric Akt1/2/3 inhibitor, with wide preclinical antitumor activity predicted long terminal elimination half-life (t1/2). Methods: was initially given QOD; due to the observed t1/2, QW schedule also evaluated. Archival tumor circulating nucleic acid were analyzed for PTEN PIK3CA aberrations. Pharmacodynamic (PD) analyses of AKT downstream target phosphorylation (p)...
3584 Background: ARQ 197 is a non-ATP competitive small molecule inhibitor of c-Met, receptor tyrosine kinase activated by hepatocyte growth factor/scatter factor and implicated in cell migration, invasion, proliferation angiogenesis. Methods: Patients (pt) with advanced, safely biopsiable, solid tumors were enrolled to determine safety, tolerability, maximum tolerated dose (MTD), pharmacokinetics, pharmacodynamics preliminary antitumor activity. Pre post therapy tumor biopsies mandated for...