Christopher Trevisani
A5087181491- Lymphoma Diagnosis and Treatment
- T-cell and Retrovirus Studies
- Galectins and Cancer Biology
- Metabolism and Genetic Disorders
- CAR-T cell therapy research
- Mitochondrial Function and Pathology
- Chronic Lymphocytic Leukemia Research
- Immune Cell Function and Interaction
- Ubiquitin and proteasome pathways
- Diet and metabolism studies
- Neuroscience and Neuropharmacology Research
- Diabetes and associated disorders
- Neurological and metabolic disorders
- Protein Degradation and Inhibitors
- Metabolomics and Mass Spectrometry Studies
- interferon and immune responses
- Cutaneous lymphoproliferative disorders research
- Neuroinflammation and Neurodegeneration Mechanisms
- Infectious Encephalopathies and Encephalitis
- Immunotherapy and Immune Responses
- Memory and Neural Mechanisms
Dana-Farber Cancer Institute
2020-2024
SUNY Upstate Medical University
2022-2024
High Point University
2021
Sigma Tau (Italy)
1986
Tumor cells orchestrate their microenvironment. Here, we provide biochemical, structural, functional, and clinical evidence that Cathepsin S (CTSS) alterations induce a tumor-promoting immune microenvironment in follicular lymphoma (FL). We found CTSS mutations at Y132 6% of FL (19/305). Another 13% (37/286) had amplification, which was associated with higher expression. lead to accelerated autocatalytic conversion from an enzymatically inactive profrom active increased substrate cleavage,...
Abstract Purpose: Develop a novel therapeutic strategy for patients with subtypes of mature T-cell and NK-cell neoplasms. Experimental Design: Primary specimens, cell lines, patient-derived xenograft models, commercially available, proprietary anti-KLRG1 antibodies were used screening, target, functional validation. Results: Here we demonstrate that surface KLRG1 is highly expressed on tumor cells in subsets extranodal NK/T-cell lymphoma (ENKTCL), T-prolymphocytic leukemia (T-PLL),...
Binge drinking is a common occurrence in the United States, but high concentration of alcohol blood has been shown to have reinforcing and reciprocal effects on neuroimmune system both dependent non-dependent scenarios. The first part this study examined alcohol's astrocytic response central amygdala basolateral (BLA) model. C57BL/6J mice were given access either ethanol, water, or sucrose during "drinking dark" paradigm, astrocyte number astrogliosis measured using immunohistochemistry....
Abstract Carnitine is an essential co‐factor in the catabolism of fats as energy source. The primary purpose this study was to investigate effect running a marathon on metabolism carnitine by endurance‐trained athletes, and evaluate administration performance such exercise. effects mitochondrial enzymes cellular anti‐oxidants were also examined assess whether expression these activities altered Subjects 10 experienced male runners aged between 19 25 years. Running caused fall plasma content...
<p>Supplementary Methods and Figures</p>
<p>Supplementary Methods and Figures</p>
<div>AbstractPurpose:<p>Develop a novel therapeutic strategy for patients with subtypes of mature T-cell and NK-cell neoplasms.</p>Experimental Design:<p>Primary specimens, cell lines, patient-derived xenograft models, commercially available, proprietary anti-KLRG1 antibodies were used screening, target, functional validation.</p>Results:<p>Here we demonstrate that surface KLRG1 is highly expressed on tumor cells in subsets extranodal NK/T-cell lymphoma...
<div>AbstractPurpose:<p>Develop a novel therapeutic strategy for patients with subtypes of mature T-cell and NK-cell neoplasms.</p>Experimental Design:<p>Primary specimens, cell lines, patient-derived xenograft models, commercially available, proprietary anti-KLRG1 antibodies were used screening, target, functional validation.</p>Results:<p>Here we demonstrate that surface KLRG1 is highly expressed on tumor cells in subsets extranodal NK/T-cell lymphoma...