A5058417787- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Viral-associated cancers and disorders
- CNS Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Blood Coagulation and Thrombosis Mechanisms
- Blood properties and coagulation
- Immune Response and Inflammation
- Antimicrobial Peptides and Activities
- Ovarian cancer diagnosis and treatment
- Protein Tyrosine Phosphatases
- Venous Thromboembolism Diagnosis and Management
- Ubiquitin and proteasome pathways
- Atrial Fibrillation Management and Outcomes
- Cell death mechanisms and regulation
- Adipokines, Inflammation, and Metabolic Diseases
- Ferroptosis and cancer prognosis
- Cancer-related gene regulation
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- NF-κB Signaling Pathways
- Immunodeficiency and Autoimmune Disorders
Mater Research
2019-2024
The University of Queensland
2017-2024
Translational Research Institute
2019-2024
Princess Alexandra Hospital
2019
BC Cancer Agency
2011-2018
University of British Columbia
2011-2018
Temple University
2009-2015
Emory University Hospital
2014
Boston University
2006
Boston Medical Center
2006
Understanding the immunobiology of 15% to 30% patients with follicular lymphoma (FL) who experience progression disease within 24 months (POD24) remains a priority. Solid tumors low levels intratumoral immune infiltration have inferior outcomes. It is unknown whether similar relationship exists between POD24 in FL.Digital gene expression using custom code set-five effector, six checkpoint, one macrophage molecules-was applied discovery cohort early- and advanced-stage FL (n = 132). T-cell...
Abstract TLR2 plays a key role in the initiation of cellular innate immune responses by wide range bacterial products. TLRs signaling, including and its coreceptors TLR1 TLR6, is mediated number specific ligands. Although many TLR-mediated cell signaling pathways have been elucidated past few years, molecular mechanisms that lead to activation are still poorly understood. In this study, we investigate interaction PorB from Neisseria meningitidis with describe direct binding protein for first...
Tumor cells orchestrate their microenvironment. Here, we provide biochemical, structural, functional, and clinical evidence that Cathepsin S (CTSS) alterations induce a tumor-promoting immune microenvironment in follicular lymphoma (FL). We found CTSS mutations at Y132 6% of FL (19/305). Another 13% (37/286) had amplification, which was associated with higher expression. lead to accelerated autocatalytic conversion from an enzymatically inactive profrom active increased substrate cleavage,...
Abstract Objective Epstein‐Barr virus‐positive diffuse large B‐cell lymphoma (EBV ‐pos DLBCL) is a recently identified entity. Data regarding outcome to frontline immuno‐chemotherapy are conflicting. Although the prognostic impact of tumour microenvironment (TME) in EBV ‐neg DLBCL well‐established, it remains untested whether TME influences survival DLBCL. There no data with new digital gene expression technologies that simultaneously interrogate virus, B cells and (TME). Methods We used...
Summary Childhood obesity is rapidly increasing in prevalence. We compared circulating membrane‐bound tissue factor ( FIII , F 3) procoagulant activity TF ‐ PCA ) and plasma markers of coagulation, fibrinolysis endothelial dysfunction 21 obese (10·1 ± 1·5 years, mean standard deviation) 22 healthy weight children (9·9 1·6 years), classified by B ody M ass I ndex BMI ). VII coagulant FVII : C ), plasminogen activator inhibitor PAI ‐1, SERPINE 1) soluble vascular cell adhesion molecule 1 sVCAM...
ABSTRACT Meningococcal porin PorB is an inhibitor of apoptosis induced via the intrinsic pathway in various cell types. This effect attributed to prevention mitochondrial depolarization and subsequent release proapoptotic factors. To determine whether globally inhibited by PorB, we compared extrinsic pathways HeLa cells. Interestingly, does not prevent tumor necrosis factor alpha plus cycloheximide, suggesting a unique specificity. Several intracellular factors regulated NF-κB, including...
Primary central nervous system lymphoma (PCNSL) occurring following organ transplantation (post-transplantation lymphoproliferative disorder [PTLD]) is a highly aggressive non-Hodgkin lymphoma. It typically treated with high-dose methotrexate-based regimens. Outcomes are dismal and clinical trials lacking. almost always Epstein–Barr virus (EBV) associated. Two patients (CA1-2) presented EBV-associated PCNSL after renal transplant. CA1 was on hemodialysis had prior disseminated cryptococcus...
Data on the prognostic impact of pretherapy 18F-fluorodeoxyglucose–positron emission tomography (FDG-PET) in follicular lymphoma (FL) is conflicting. The predictive utility total metabolic tumor volume (TMTV) and maximum standardized uptake value (SUVmax) outcome appears to vary between regimens. Chemoimmunotherapies extent T-cell depletion they induce. role intratumoral T cells FDG-PET parameters undefined. We assessed quantified by multiple methodologies. Low associated with approximately...
OBJECTIVE To determine tissue factor procoagulant activity (TF-PCA) in patients with type 1 diabetes and to examine effects of hyperglycemia plus hyperinsulinemia on TF-PCA. RESEARCH DESIGN AND METHODS We have determined circulating TF-PCA other coagulation factors under basal (hyperglycemic) conditions, after acute correction hyperglycemia, response 24 h selective nine diabetic seven nondiabetic control subjects. RESULTS As shown previously 2 diabetes, plasma VIIa (FVIIa) were higher than...
<b><i>Introduction:</i></b> Hodgkin lymphoma (HL) is deficient in major histocompatibility complex class I, rendering it susceptible to antitumoral immunity by natural killer (NK) cells. Despite the functional impairment of PD-1<sup>+</sup> NK cells HL, underlying mechanisms cell dysfunction remain unclear. <b><i>Methods:</i></b> This study involved 14 HL patients and SNK10/KHYG-1 lines assess activation against cancer Activation...
In classical Hodgkin lymphoma (cHL), responsiveness to immune-checkpoint blockade (ICB) is associated with specific tumor microenvironment (TME) and peripheral blood features. The role of ICB in nodular lymphocyte predominant (NLPHL) not established. To gain insights into its potential NLPHL, we compared TME signatures between HLs using an integrative multiomic analysis. A discovery/validation approach 121 NLPHL 114 cHL patients highlighted >2-fold enrichment programmed cell death-1 (PD-1)...
Abstract Background We report extended follow-up of TROG99.03, a randomised phase III trial in early-stage follicular lymphoma (ESFL) including new information on the role adjuvant rituximab and translational studies. Methods Patients with ESFL were to involved-field radiotherapy (IFRT) or IFRT plus 6-cycles cyclophosphamide/vincristine/prednisolone (IFRT+CVP). From 2006 was added IFRT+CVP (IFRT+R-CVP). Clinical multi-omic parameters evaluated. Findings validated two independent cohorts (99...
Abstract Follicular lymphoma (FL) is the most common indolent non‐Hodgkin lymphoma. Twenty to twenty‐five percent of FL patients have progression disease within 24 months. These may benefit from immunotherapy if intact antigen presentation present. Molecular mechanisms impairing major histocompatibility complex class‐I (MHC‐I) in remain undefined. Here, by sequencing 172 tumours, we found MHC‐I transactivator NLRC5 was frequent gene abnormality pathway. Pyrosequencing showed that epigenetic...