A5063607680- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Lymphoma Diagnosis and Treatment
- MicroRNA in disease regulation
- Histone Deacetylase Inhibitors Research
- Cancer-related gene regulation
- Viral-associated cancers and disorders
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Cytomegalovirus and herpesvirus research
- Zebrafish Biomedical Research Applications
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Neurogenesis and neuroplasticity mechanisms
- Genomics and Chromatin Dynamics
- Circular RNAs in diseases
- IL-33, ST2, and ILC Pathways
- Genetics and Neurodevelopmental Disorders
- Hematopoietic Stem Cell Transplantation
The University of Queensland
2015-2024
Tianjin Children's Hospital
2021
Translational Research Institute
2015-2018
MRC Laboratory of Molecular Biology
2013
Shanghai Institutes for Biological Sciences
2011-2012
Chinese Academy of Sciences
2011-2012
Center for Excellence in Molecular Cell Science
2011-2012
// Qingyan Cui 1 , Frank Vari Alexandre S. Cristino Carlos Salomon 2, 3 Gregory E. Rice 2 Muhammed B. Sabdia Dominic Guanzon Palma Marina Mathew Dipti Talaulikar 4, 5 Sanjiv Jain 4 Erica Han Mark Hertzberg 6 Clare Gould Pauline Crooks Gayathri Thillaiyampalam Colm Keane 1, 7 and Maher K. Gandhi University of Queensland Diamantina Institute, Brisbane, QLD, Australia Centre for Clinical Research, Concepción, Chile Canberra Hospital, Garran, ACT, National Medical School, Prince Wales...
<b><i>Introduction:</i></b> Hodgkin lymphoma (HL) is deficient in major histocompatibility complex class I, rendering it susceptible to antitumoral immunity by natural killer (NK) cells. Despite the functional impairment of PD-1<sup>+</sup> NK cells HL, underlying mechanisms cell dysfunction remain unclear. <b><i>Methods:</i></b> This study involved 14 HL patients and SNK10/KHYG-1 lines assess activation against cancer Activation...
Abstract Activation of the IRE1α-endonuclease is critical for Natural Killer (NK)-cell function. We describe a novel regulatory role in fine-tuning NK-cell effector functions through an inter-connected activation transcription factor XBP1s and inhibition microRNA-34a-5p (miR-34a-5p) to modulate PD-1 immune checkpoint expression. NK-cells, when exposed cancer cells, activate mediated decay miR-34a-5p. This reduces miR-34a-5p consequently increases expression target genes XBP1 PD-1. not only...