A5028457933- Lymphoma Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Chronic Lymphocytic Leukemia Research
- Health and Medical Research Impacts
- CNS Lymphoma Diagnosis and Treatment
- Innovations in Medical Education
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- Diversity and Career in Medicine
- SARS-CoV-2 detection and testing
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Viral-associated cancers and disorders
- Biosensors and Analytical Detection
- Systemic Lupus Erythematosus Research
- Long-Term Effects of COVID-19
- Complementary and Alternative Medicine Studies
- Radiopharmaceutical Chemistry and Applications
- Respiratory viral infections research
- Protein Degradation and Inhibitors
- Bacterial Genetics and Biotechnology
- Lung Cancer Treatments and Mutations
- Bioinformatics and Genomic Networks
- Immunodeficiency and Autoimmune Disorders
- CAR-T cell therapy research
University of British Columbia
2014-2022
BC Cancer Agency
2013-2021
University of Calgary
2021
BC Centre for Disease Control
2021
Spinal Cord Injury BC
2020
McMaster University
2017
University of Manitoba
2017
University of Alberta
2017
McGill University
2017
University of Toronto
2017
Abstract Primary testicular diffuse large B cell lymphoma ( PTL ) is an aggressive malignancy that occurs in the immune‐privileged anatomical site of testis. We have previously shown structural genomic rearrangements involving MHC class II transactivator CIITA and programmed death ligands PDLs 1 2 are frequent across multiple entities. Specifically , we found PDL locus by fluorescence situ hybridization FISH ). However, breakpoint anatomy rearrangement partners were undetermined, while had...
BackgroundAngiotensin converting enzyme 2 (ACE2) protein serves as the host receptor for SARS-CoV-2, with a critical role in viral infection. We aim to understand population level variation of nasopharyngeal ACE2 transcription people tested COVID-19 and relationship between SARS-CoV-2 load, while adjusting expression of: (i) complementary protease, Transmembrane serine protease (TMPRSS2), (ii) soluble ACE2, (iii) age, (iv) biological sex. The gene was targeted measure transmembrane...
Context MD/PhD programmes provide structured paths for physician-scientist training. However, considerable proportions of graduates these do not pursue careers in research consistent with their Objectives We sought to identify factors associated sustained involvement after completion all postgraduate Methods Anonymised data from a national survey Canadian programme who had completed training (n = 70) were analysed. Multivariable logistic regression was used measure the associations between...
Combined MD/PhD programs provide a structured path for physician-scientist training, but assessment of their success within Canada is limited by lack quantitative data. We collected outcomes data graduates Canadian programs. developed and implemented Web-based survey consisting 41 questions designed to collect program alumni from 8 universities who had graduated before September 2015. Respondents were categorized into 2 groups according whether they or not completed all training. Of the 186...
Abstract Tumour‐promoting inflammation is an emerging hallmark of cancer that increasingly recognised as a therapeutic target. As constituent measure inflammation, tumour‐infiltrating neutrophils (TINs) have been associated with inferior prognosis in several cancers. We analysed clinically annotated cohorts clear cell renal carcinoma (ccRCC) to assess the presence within tumour microenvironment function outcome. centrally reviewed ccRCC surgical resection and fine‐needle aspiration (FNA)...
SLE is associated with increased risk of diffuse large B-cell lymphoma (DLBCL). DLBCL routinely classified by cell origin (COO), germinal centre (GCB) being more common and indicating better prognosis in the general population. We studied COO subtyping patients diagnosed their survival.We evaluated 20 cases DLBCL. Immunohistochemistry analysis was performed (BCL2, MYC, BCL6, CD10, CD20, FOXP1, GCET1, MUM1) tissue microarrays. examined associations between molecular clinical features,...
Abstract In this study, we evaluate the impact of whole genome and transcriptome analysis (WGTA) on predictive molecular profiling histologic diagnosis in a cohort advanced malignancies. WGTA was used to generate reports including alterations site/tissue origin prediction. Two reviewers analyzed genomic reports, clinical history, tumor pathology. We National Comprehensive Cancer Network (NCCN) consensus guidelines, Food Drug Administration (FDA) approvals, provincially reimbursed treatments...
Although MD/PhD programs require considerable commitment on behalf of students and learning institutions, they serve as an integral means training future physician-scientists; individuals who engage in translational medicine. As attrition from these has longstanding effects the community medicine comes at substantial cost to programs, we aimed identify determinants that were associated with satisfaction among graduates, a feature might inform limiting program attrition. Anonymized data...
The COVID-19 pandemic has highlighted the need for generic reagents and flexible systems in diagnostic testing. Magnetic bead-based nucleic acid extraction protocols using 96-well plates on open liquid handlers are readily amenable to meet this need. Here, one such approach is rigorously optimized minimize cross-well contamination while maintaining sensitivity.
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Abstract Introduction: Primary mediastinal large B cell lymphoma (PMBCL) is a distinct subtype of aggressive that arises from thymic medullary cells and characteristically presents as mass in the anterior mediastinum. A proportion PMBCL patients suffer refractory or relapsing disease, subsequent salvage therapies are frequently ineffective. Development targeted impeded by lack knowledge about mutational landscape genomes mutation-associated phenotypes. We recently reported somatic mutations...
Summary Background Angiotensin converting enzyme 2 ( ACE2 ) serves as the host receptor for SARS-CoV-2, with a critical role in viral infection. We aim to understand population level variation of nasopharyngeal expression people tested COVID-19 and relationship between SARS-CoV-2 RNA load, while adjusting complementary protease, Transmembrane serine protease TMPRSS2) , soluble age, biological sex. Methods A cross-sectional study n=424 participants aged 1-104 years referred testing was...