A5033985475- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Genomics and Chromatin Dynamics
- Cancer Treatment and Pharmacology
- Porphyrin Metabolism and Disorders
- Renal Diseases and Glomerulopathies
- Blood groups and transfusion
- Complement system in diseases
- Cancer Risks and Factors
- Lung Cancer Treatments and Mutations
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
- Erythrocyte Function and Pathophysiology
- HIV/AIDS Research and Interventions
- Venous Thromboembolism Diagnosis and Management
- Neurological and metabolic disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Cutaneous Melanoma Detection and Management
- Pregnancy and preeclampsia studies
- Platelet Disorders and Treatments
- Maternal and fetal healthcare
- Melanoma and MAPK Pathways
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Acute Myeloid Leukemia Research
University of Miami
1998-2025
Jackson Memorial Hospital
2016-2021
Sylvester Comprehensive Cancer Center
2016
Acute lymphoblastic leukemia and other aggressive lymphoid malignancies like Burkitt leukemia/lymphoma have high incidence of central nervous system (CNS) involvement. Various solid tumors, most notably breast cancer, can also metastasize into the CNS as a late stage complication causing devastating effects. Intrathecal (IT) chemotherapy consisting methotrexate, cytarabine, or two in combination is frequently used for prophylaxis treatment metastasis. Because toxicity these chemotherapeutic...
ABSTRACT Immune thrombotic thrombocytopenic purpura (iTTP) is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and microvascular occlusion secondary to acquired ADAMTS13 deficiency. Contemporary data regarding iTTP treatment practices in the US, including use of caplacizumab, are lacking. We aimed characterize demographics therapies, medications apheresis practices, patients with US. retrospectively analyzed cases at 15 sites US that provide comprehensive care for iTTP....
Melanomas demonstrate chromosomal instability (CIN). In fact, CIN can be used to differentiate melanoma from benign nevi. The exact molecular mechanisms that drive in have yet fully elucidated. Cancer/testis antigens are a unique group of germ cell proteins found primarily expressed as compared abnormal expression these proteins, normally expected only the testis and ovaries, somatic cells may lead interference with normal cellular pathways. Germ particularly critical meiosis proteins. Here,...
Prior studies have suggested that immune thrombotic thrombocytopenic purpura (iTTP) may display seasonal variation; however, methodologic limitations and sample sizes diminished the ability to perform a rigorous assessment. This 5-year retrospective study assessed epidemiology of iTTP determined whether it displays pattern. Patients with both initial relapsed (defined as disintegrin metalloprotease thrombospondin type motifs 13 activity <10%) from 24 tertiary centers in Australia, Canada,...
Early diagnosis gives melanoma patients the best chance for long term survival. However discrimination of an early from unusual/atypical benign nevus can represent a significant challenge. There are no current pathological markers to definitively define malignant potential in these indeterminate lesions. Thus, there is need improved diagnostic tools. Chromosomal instability (CIN) hallmark cancer and markedly prevalent melanoma. Advances genomics have opened door development molecular tools...
Germ cell protein expression in melanoma has been shown to correlate with malignancy, severity of disease and serve as an immunologic target for therapy. However, very little is known about the role that germ proteins play cancer development. Unique pathways include those involved immortalization, genetic evolution, energy metabolism. There ever increasing recognition within tumors there a subpopulation cells stem-cell-like characteristics driving tumorgenesis. Stem biology intertwined....
The etiology of anemia in liver cirrhosis is multifactorial; one less recognized cause hemolytic due to spur cells, known as cell anemia. We present the case a 57-year-old woman with alcoholic who presented symptomatic macrocytic hemoglobin level 7.4 g/dL and signs decompensated disease. Notably, she had no overt bleeding. Further workup was consistent hemolysis, peripheral smear demonstrating cells. patient treated both steroids IVIG, although eventually expired. characteristic morphology...
Acute intermittent porphyria (AIP) is a disorder that affects heme synthesis, leading to accumulation of upstream precursors, and can cause an array visceral neurological symptoms. These be severely debilitating even fatal if not diagnosed treated in timely fashion. We outline rare case severe AIP masquerading as ascending polyneuropathy how it was correctly with extended course hemin despite initial barriers biochemical testing for AIP.
Abstract Background: It is documented that socioeconomic factors, such as lack of access to health care and inadequate treatment after diagnosis contribute disparities in breast cancer, but these factors alone do not explain cancer disparities. Several studies suggest several other environmental, biological behavioral may play a significant role the observed outcomes women minorities. In this study we compare Afro-Caribbean (AC) born Caribbean living United States Afro-American (AA) States,...
7547 Background: Allogeneic Stem Cell Transplant (alloSCT) continues to be the optimal consolidation strategy for many patients with AML; cytogenetic and molecular abnormalities are known predictors of post-transplant outcomes. There is increasing evidence that Molecular Minimal Residual Disease (MMRD) following induction has important prognostic implications its value in prediction relapse elucidated. We aim evaluate impact genetics pre-transplant MMRD on clinical outcomes alloSCT. Methods:...
Byrnes, D.; Antoni, M.; Goodkin, K.; Efantis-Potter, J.; Simon, T.; Munajj, Ironson, G.; Asthana, Fletcher, M. Author Information
Introduction: Acute intermittent porphyria (AIP) is a disorder of heme synthesis and leads to accumulation precursors causing abdominal neurological symptoms. AIP can be debilitating even fatal without correct diagnosis timely treatment. We outline rare case severe AIP, masquerading as Guillain-Barre Syndrome (GBS), treated with an extended course hemin. Case Description/Methods: 21 year-old female presented hospital in Ecuador 11 days after right ovarian cyst removal, for pain convulsions....