A5071061072- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- Antibiotic Use and Resistance
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Bacterial Identification and Susceptibility Testing
- Infection Control and Ventilation
- Immunodeficiency and Autoimmune Disorders
- Vaccine Coverage and Hesitancy
- Nosocomial Infections in ICU
- Respiratory Support and Mechanisms
- Blood disorders and treatments
- COVID-19 Impact on Reproduction
- Public Health and Environmental Issues
- Artificial Intelligence in Healthcare and Education
- COVID-19 diagnosis using AI
- COVID-19 and Mental Health
- Clinical Reasoning and Diagnostic Skills
- Diabetes and associated disorders
- Antibiotic Resistance in Bacteria
- SARS-CoV-2 detection and testing
- Hematological disorders and diagnostics
- T-cell and B-cell Immunology
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
2014-2025
Office of Infectious Diseases
2021
Background: Regional information regarding the characteristics of patients with coronavirus disease (COVID)-19 is needed for a better understanding pandemic.Objective: The objective study to describe clinical features COVID-19 diagnosed in tertiary-care center Mexico City and assess differences according treatment setting (ambulatory vs. hospital) need intensive care (IC).Methods: We conducted prospective cohort, including consecutive
Objective: To describe empirical antimicrobial prescription on admission in patients with severe COVID-19, the prevalence of Hospital-Acquired Infections, and susceptibility patterns causing organisms. Methods: In this prospective cohort study a tertiary care center Mexico City, we included consecutive admitted COVID-19 between March 20th June 10th evaluated occurrence HAI. Results: 794 were during period. Empiric antibiotic treatment was started 92% (731/794); most frequent regimes...
Abstract Background Early treatment of coronavirus disease 2019 (COVID-19) with remdesivir in high-risk patients, including those immunosuppression different causes, has not been evaluated. The objective this study was to assess the clinical effectiveness early among patients mild moderate COVID-19 at high risk progression. Methods This prospective cohort comparative conducted a tertiary referral center Mexico City. Patients for progression were treated an ambulatory 3-day course remdesivir....
•Clostridioides difficile infection (CDI) is widespread in hospitals.•An important rate reduction CDI was noticed a COVID-19 hospital.•Better adherence to hand hygiene and contact precautions noticed. Healthcare facility-onset Clostridioides rates substantially dropped Mexican hospital after its conversion full setting, despite heavy contamination of the environment previous year. Better may help explain this finding. most frequent healthcare-associated United States.1Magill SS Edwards JR...
Antimicrobial resistance is a global threat to public health. Chat Generative Pre-trained Transformer (ChatGPT®) language model tool based on artificial intelligence. ChatGPT® could analyze data from antimicrobial susceptibility tests in real time, especially places where infectious diseases (ID) specialists are not available. We aimed evaluate the agreement between and ID regarding appropriate antibiotic prescription simulated cases. Using microbiological isolates recovered our center, we...
Abstract Background Limited information exists regarding the natural history of SARS-CoV-2 infection in infants, including proportion asymptomatic disease. Moreover, impact repeated infections on immunity and clinical presentation is unknown. The possibility non-severe symptoms related to viral variants has not been explored. Incidence rate first subsequent infections. Methods This meticulous prospective cohort study, conducted from January 1st 2022 March 30th 2024, followed healthy newborns...
Background: First-line treatments for methicillin-susceptible S. aureus (MSSA) bacteraemia are nafcillin, oxacillin, or cefazolin. Regional shortages of these antibiotics force clinicians to use other options like dicloxacillin and cephalotin. This study aims describe compare the safety efficacy cephalotin treatment MSSA bacteraemia. Methods: retrospective was conducted in a referral centre Mexico City. We identified isolates blood cultures from 1 January 2012 31 December 2022. Patients ≥ 18...
Background: Even though worldwide death rates from coronavirus disease 2019 (COVID-19) have decreased, the threat of progression and for high-risk groups continues. Few direct comparisons between available severe acute respiratory syndrome 2 (SARS-CoV-2) antivirals been made. Objective: We aimed to compare two SARS-CoV-2 (nirmatrelvir/ritonavir remdesivir) against all-cause hospitalization or death. Design: This is a propensity score-matched cohort study. Methods: included all outpatients...
Infections due to carbapenem-resistant Gram-negative bacteria are emerging as an important challenge in health-care settings and a growing concern worldwide. Lateral flow immunoassay NG-Test
Dexamethasone implementation for COVID-19 management represented a milestone but data regarding its impact and safety have not been consistently reproduced. We aimed to evaluate in-hospital mortality before after the of corticosteroid treatment (CS-T) severe critical COVID-19. conducted cohort study that included patients admitted with The primary outcome was death during hospitalization. Secondary outcomes length stay (LOS), need invasive mechanical ventilation (IMV), time IMV initiation,...
Relatively low SARS-CoV-2 reinfection rates have been reported in vaccinated individuals, but updates considering the Omicron variant are lacking.The objective of study was to provide a current estimate rate highly immunized population.A prospective cohort Mexican hospital workers followed (March 2020-February 2022). Reinfection defined as occurrence two or more episodes COVID-19 separated by period ≥ 90 days without symptoms. The calculated number per 100,000 persons day.A total 3732...
: Invasive Fungal Infections (IFI) are emergent complications of COVID-19. In this study, we aim to describe the prevalence, related factors, and outcomes IFI in critical COVID-19 patients.
T cells from systemic lupus erythematosus (SLE) patients display a wide array of anomalies in peripheral immune tolerance mechanisms. The role ubiquitin ligases such as Cbl-b has been described recently these phenomena. However, its resistance to suppression phenotype SLE not characterized, which was the aim present study. Thirty (20 with active disease and 10 complete remission) 30 age- sex-matched healthy controls were recruited. Effector (CD4+ CD25- ) regulatory CD25+ (Tregs purified...
Few studies regarding infectious causes of febrile neutropenia (FN) in Mexico are available.
Recognition of risk factors for hospital-acquired infections (HAI) in patients with COVID-19 is warranted. We aimed to describe associated the development HAI severe COVID-19. conducted a retrospective cohort study including all adult admitted between March 2020 and November 2020. The primary outcome was development. Bivariate multiple logistic regression models were constructed. Among 1540 patients, occurred 221 (14%). A total 299 episodes registered. most common...
Infections caused by carbapenem-resistant Gram-negative bacteria (CR-GNB) are a significant cause of mortality and represent serious challenge to health systems. The early identification predictors could guide appropriate treatment follow-up. We aimed identify the factors associated with 90-day all-cause in patients CR-GNB infections.We conducted cohort study from 1 January 2019 30 April 2022. primary outcome was death any during first 90 days after date CR-GNB-positive culture. Secondary...
Healthcare workers (HCWs) not fulfilling the coronavirus disease 2019 (COVID-19) case definition underwent severe acute respiratory virus 2 (SARS-CoV-2) screening. Risk of exposure, adherence to personal protective equipment (PPE), and symptoms were assessed. In total, 2,000 HCWs screened: 5.5% positive for SARS-CoV-2 by polymerase chain reaction (PCR). There no differences in PPE use between SARS-CoV-2-positive -negative (adherence, >90%). Nursing kitchen staff independently associated with results.
Immunocompromised patients are at risk of opportunistic infections. This is a 67-year-old woman with systemic sclerosis and knee osteoarthritis who underwent left total arthroplasty in 2009. In 2018 she surgery for presumed aseptic loosening. Inflammation purulent fluid were found; implant was removed replaced static spacer. Three weeks later, H. capsulatum isolated. She successfully treated itraconazole 18 months; cultures on revision spacer replacement negative.