A5023250466- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Organ Donation and Transplantation
- Renal Transplantation Outcomes and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Transplantation: Methods and Outcomes
- COVID-19 Clinical Research Studies
- Liver physiology and pathology
- SARS-CoV-2 and COVID-19 Research
- Renal Diseases and Glomerulopathies
- Hepatitis B Virus Studies
- Abdominal vascular conditions and treatments
- Genetic and Kidney Cyst Diseases
- Cancer, Lipids, and Metabolism
- Gallbladder and Bile Duct Disorders
- Ferroptosis and cancer prognosis
- Pregnancy and Medication Impact
- Pneumocystis jirovecii pneumonia detection and treatment
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Treatments and Studies
- Congenital Anomalies and Fetal Surgery
- Lymphoma Diagnosis and Treatment
Montefiore Medical Center
2016-2025
Albert Einstein College of Medicine
2014-2025
Montefiore Einstein Comprehensive Cancer Center
2024
Yeshiva University
2021
Mayo Clinic
2019
WinnMed
2019
The Netherlands Cancer Institute
2018
Princess Margaret Cancer Centre
2016
National Institutes of Health
2016
National Cancer Institute
2016
Ischemic cold storage (ICS) of livers for transplant is associated with serious posttransplant complications and underuse liver allografts.To determine whether portable normothermic machine perfusion preservation obtained from deceased donors using the Organ Care System (OCS) Liver ameliorates early allograft dysfunction (EAD) ischemic biliary (IBCs).This multicenter randomized clinical trial (International Randomized Trial to Evaluate Effectiveness Portable Preserving Assessing Donor Livers...
Abstract Chemokines, chemotactic cytokines, may promote hepatic inflammation in chronic hepatitis C virus (HCV) infection through the recruitment of lymphocytes to liver parenchyma. We evaluated association between and fibrosis CXCR3-associated chemokines, interferon-γ (IFN-γ)–inducible protein 10 (IP-10/CXCL10), monokine induced by IFN-γ (Mig/CXCL9), interferon-inducible T cell α chemoattractant (I-TAC/CXCL11), HCV infection. Intrahepatic mRNA expression these chemokines was analyzed 106...
The objective of this study was to evaluate the effect systematic utilization extended donor criteria liver allografts (EDC), including living (LDLT), on patient access transplantation (LTX).Utilization that do not meet traditional (EDC) offer immediate expansion pool. EDC are typically allocated by transplant center rather than regional wait-list priority (RA). This single-institution series compares outcomes and RA allocation determine impact use LTX.The authors conducted a retrospective...
No prior studies have shown that pre-operative loco-regional therapy for hepatocellular carcinoma (HCC) improves survival following orthotopic liver transplantation (OLT). We performed subgroup analyses according to pathologic HCC stage among 168 patients who underwent OLT test the hypothesis confers a advantage in at intermediate risk recurrence. Patients with T3 meeting proposed UCSF expanded criteria (single lesion not exceeding 6.5 cm or two three lesions none > 4.5 total tumor diameter...
We investigated the prevalence and clinical outcomes of COVID-19 in recipients kidney transplants Bronx, New York, one epicenters pandemic. Between March 16 June 2, 2020, 132 transplant tested positive by SARS-CoV-2 RT-PCR. From May 3 to July 29, 912 were screened for IgG antibodies during routine clinic visits, which 16.6% positive. Fifty-five 152 patients had previously RT-PCR, while remaining 97 did not have significant symptoms been The infection was 23.4% 975 either RT-PCR or IgG. Older...
Somatic mutation levels in human liver increase with age and are higher differentiated hepatocytes than residential LSCs.
Corticosteroids withdrawal from immunosuppressive regimens has thus far been associated with increased risk of acute rejection episodes. In this study, basiliximab, a chimeric monoclonal interleukin-2 receptor antagonist, added to maintenance regimen consisting cyclosporine microemulsion and mycophenolate mofetil was studied for its effectiveness in allowing early corticosteroid de novo renal allograft recipients.Primary transplant recipients receiving cyclosporine-microemulsion, mofetil,...
Expression of the pluripotent molecule TNF in a focused and antigen-restricted fashion might provide an advantage to host organism. Given central role T cells antigen-specific immunity, we examined whether activated express on their cell surface. FACS analysis highly purified normal human labeled with anti-TNF mAb revealed that surface when signaled synergistic combination calcium ionophore, ionomycin, protein kinase C activator, 12-o-tetradecanoyl phorbol acetate. Cell radioiodination...
The purpose of donor evaluation for adult-to-adult living liver transplantation (LDLT) is to discover medical conditions that could increase the postoperative risk complications and determine whether can yield a suitable graft recipient. We report outcomes LDLT candidates evaluated in large multicenter study LDLT. records all their respective recipients between 1998 2003 were reviewed as part Adult-to-Adult Living Donor Liver Transplantation Cohort Study (A2ALL). recorded along with...
This randomized, prospective, multicenter trial compared the safety and efficacy of steroid-free immunosuppression (IS) to 2 standard IS regimens in patients undergoing transplantation for hepatitis C virus (HCV) infection. The outcome measures were acute cellular rejection (ACR), severe HCV recurrence, survival. randomized (1:1:2) tacrolimus (TAC) corticosteroids (arm 1; n = 77), mycophenolate mofetil (MMF), TAC, 2; 72), or MMF, daclizumab induction with no 3; 146). In all, 295 RNA-positive...
Background. Unlike simple cold storage (CS), pulsatile machine preservation (MP) of kidneys for transplantation permits pharmacologic manipulation the perfusate and aids in pretransplant assessment kidney graft. These characteristics MP may have importance era increasing use extended criteria donor kidneys. The overall aim this article is to critically assess practices at our unit with respect graft function. Specific aims are (1) compare influence versus CS on function, (2) determine which...
Histologic injury caused by recurrent hepatitis C virus (HCV) has been reported in up to 90% of HCV-infected patients who undergo liver transplantation with a cadaveric graft. However, the natural history HCV after living donor (LDLT) is not well described. We performed retrospective analysis 68 consecutive adult patients: 45 recipients grafts (CAD) were compared 23 LDLT patients. Elevated serum transaminases, positive RNA, and biopsy consistent histologic evidence defined recurrence. When...
<h3>Objective:</h3> To analyze the impact of preexisting portal vein thrombosis (PVT) on operative management and outcome liver transplantation. <h3>Design:</h3> Retrospective review 1423 patients who received transplants over 11 years. <h3>Setting:</h3> Tertiary referral center. <h3>Patients or Other Participants:</h3> Seventy underwent transplantation had PVT. <h3>Interventions:</h3> Portal thromboendovenectomy, grafting, use collateral veins for inflow during <h3>Main Outcome...
Background We conducted a prospective cohort study in highly sensitized kidney transplant candidates with calculated panel reactive antibody (cPRA) greater than 50% and on the deceased-donor waiting list for more 5 years to investigate effects of intravenous immunoglobulin (IVIG) rituximab treatment. Methods Desensitization protocol included two doses IVIG (2 g/kg, max 120 g each dose) single dose (375 mg/m2). Patients were followed up monthly by Luminex antigen beads. Whole blood gene...
Background: : Incidence of hepatocellular cancer (HCC) in the Bronx is 61% higher than rest New York State. Underserved populations are not well represented clinical trials immune checkpoint inhibitors (ICI). Methods: Demographics were tabulated for 194 patients treated with ICI at Montefiore-Einstein Comprehensive Cancer Center (MECCC) between 2017 and 2022. Categorical variables analyzed by Chi-squared test, survival was using Kaplan–Meier (KM) curves. Results: MECCC 40.7% Hispanic 20.6%...
Background. We retrospectively reviewed 213 consecutive patients who received their first liver allograft between January 1 and December 31, 1993, in order to study the impact of ischemia/preservation/reperfusion injury (IPRI) on patient graft outcome. Methods. The extent IPRI was assessed by peak value aspartate aminotransferase (ASTmax) observed within 72 hr after transplant. For purpose univariate analysis, categorical classification recipients done based upon ASTmax as follows: group 1,...
This study was designed to determine the frequency of hyperlipidemia after orthotopic liver transplantation and whether treatment with a hydroxy-methylglutaryl coenzyme A reductase inhibitor safe efficacious. Cholesterol levels were assessed in 45 consecutive adult transplants (mean ± SE). Four 22 patients on cyclosporine (CsA)(18%) three 23 FK506 (13%) had >225 mg/dl at 12 months (cholesterol for CsA [total n=22]: pre-Tx = 140±11, 1 month 183±36, 3 221±12, 6 211±11, 202±14 [P<0.01 vs....
Objective The authors analyze a single center's 11-year experience with 190 orthotopic liver transplants for congenital biliary atresia. Summary Background Data Hepatic protoenterostomy generally is the initial treatment children Despite multiple modifications of hepatic portoenterostomy, two thirds treated patients still develop recurrent cholestasis, portal hypertension, cholangitis, and cirrhosis. Therefore, only hope long-term survival in majority atresia definitive correction...