A5012262617- Inflammasome and immune disorders
- Redox biology and oxidative stress
- Vitamin D Research Studies
- Heat shock proteins research
- Sirtuins and Resveratrol in Medicine
- Viral Infectious Diseases and Gene Expression in Insects
- Histone Deacetylase Inhibitors Research
- Mitochondrial Function and Pathology
- Insect Utilization and Effects
- Immune Cell Function and Interaction
- Cancer-related Molecular Pathways
- Immune Response and Inflammation
- interferon and immune responses
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- RNA Interference and Gene Delivery
- Kawasaki Disease and Coronary Complications
- Coenzyme Q10 studies and effects
- Kruppel-like factors research
- Cancer Research and Treatments
- Retinoids in leukemia and cellular processes
- Immune cells in cancer
- Protein Kinase Regulation and GTPase Signaling
- T-cell and B-cell Immunology
- Polyamine Metabolism and Applications
Chungnam National University
2015-2020
Korea Research Institute of Bioscience and Biotechnology
2006-2014
The redox-dependent inhibition of thioredoxin (TRX) by thioredoxin-interacting protein (TXNIP) plays a pivotal role in various cancers and metabolic syndromes. However, the molecular mechanism this regulation is largely unknown. Here, we present crystal structure TRX–TXNIP complex demonstrate that TRX TXNIP mediated an intermolecular disulphide interaction resulting from novel bond-switching mechanism. Upon binding to TRX, undergoes structural rearrangement involves switching head-to-tail...
SIRT3 (sirtuin 3), a mitochondrial protein deacetylase, maintains respiratory function, but its role in the regulation of innate immune defense is largely unknown. Herein, we show that coordinates function and macroautophagy/autophagy activation to promote anti-mycobacterial responses through PPARA (peroxisome proliferator activated receptor alpha). deficiency enhanced inflammatory dysfunction, leading defective host pathological inflammation during mycobacterial infection. Antibody-mediated...
Autophagy is an important antimicrobial effector process that defends against Mycobacterium tuberculosis (Mtb), the human pathogen causing (TB). MicroRNAs (miRNAs), endogenous noncoding RNAs, are involved in various biological functions and act as post-transcriptional regulators to target mRNAs. The by which miRNAs affect antibacterial autophagy host defense mechanisms Mtb infections monocytes macrophages largely uncharacterized. In this study, we show significantly induces expression of...
Abstract Vitamin D3 upregulated protein 1 (VDUP1) is a candidate tumor suppressor, the expression of which dramatically reduced in various tissues. In this study, we found that VDUP1 suppressed during human hepatic carcinogenesis, and mice lacking are much more susceptible to diethylnitrosamine-induced hepatocarcinogenesis compared with wild type mice. VDUP1-deficient tumors proliferated significantly than had corresponding changes key cell cycle regulatory proteins. addition,...
Thioredoxin-interacting protein (TXNIP) has multiple functions, including tumor suppression and involvement in cell proliferation apoptosis. However, its role the inflammatory process remains unclear. In this report, we demonstrate that Txnip−/− mice are significantly more susceptible to lipopolysaccharide (LPS)-induced endotoxic shock. response LPS, macrophages produced higher levels of nitric oxide (NO) inducible synthase (iNOS), an iNOS inhibitor rescued from shock-induced death,...
Abstract Exosomes are 30–150 nm vesicles that secreted from a range of cells. Recently, exosomes have been the subject considerable research because there is mounting awareness their diverse functions, including role in cell–cell communication and presenting pathogens for immune responses. contain nucleic acid protein cargos, derived not only organism but also pathogens, making them suitable use disease diagnosis. The K orean rhinoceros beetle, A llomyrina dichotoma ( C oleoptera: S...
Abstract In this study, we show that INS-1 pancreatic β-cells treated for 2 h with hemolymph of larvae rhinoceros beetle, Allomyrina dichotoma , secreted about twice as much insulin compared to control cells without such treatment. Activating transcription factor 3 (ATF3) was the highest upregulated gene in DNA chip analysis. The A. dose-dependently induced increased expression levels genes encoding ATF3 and insulin. Conversely, treatment siRNA inhibited both curbed secretion. These results...
Tuberculosis (TB), a global and deadly infectious disease caused by Mycobacterium tuberculosis (Mtb), is manifested with host immune reaction. The balanced regulation between protective pathologic inflammatory responses critical to control progression TB. Chemokines are large family of cytokines that play an essential role for chemotaxis cells the sites infection. Numerous chemokines including CXCL10 were reported as potential biomarkers various stages TB In addition, several their receptors...
장수풍뎅이(Korean Rhinoceros Beettle, Allomyrina dichotoma)는 관상용으로 인기가 높으며, 애벌레는 식품으로 주목을 받고 있다. 장수풍뎅이의 대량사육 시 발생하는 질병의 원인이 최근에 virus (Oryctes rhinoceros nudivirus)인 것이 보고되었다. 그러나 아직 정확한 발병기전과 치료방법을 알지 못하여 사육농가에 심각한 경제적 손실을 주고 본 연구에서는 virus에 감염된 fat body와 장에서 조직변화가 관찰되었다. 이 때에 유전자발현이 상승하는 것으로 BTF3H4-like, SPS-like, COPB1, T-CP, HSP70를 보고한다. 결과는 조기진단과 치료에 실마리를 제공할 것이다. 그리고 안정적인 생산성 향상을 통해서 소득증대 효과 및 균일화된 대량사육을 식품원료로 인정받을 수 있을 The Korean beetle (Allomyrina dichotoma) is popular as a pet and food...
Toll-like receptors (TLR) are well-characterized pattern recognition that can recognize and respond to diverse pathogen-associated or danger-associated molecular patterns during infection. TLR signaling in macrophages triggers the intracellular pathways through recruitment of various adaptor proteins, results activation effector mechanisms important for host defense bacteria. Effector include inflammatory responses, cytokine generation, production reactive oxygen species, antimicrobial...
Abstract NF-κB subunits are important regulators of apoptosis or cellular responses triggered by tumor necrosis factor TNF-α. Termination nuclear action is regulated histone deacetylase (HDAC) corepressor proteins. However, the molecular mechanism that leads to termination not fully understood. Here, we examined functions VDUP1, a negative regulator thioredoxin, in TNF-α-mediated activation. VDUP1 level was markedly reduced TNF-α stimulation, concomitant with elevated Furthermore, Enforced...