A5101812709- Viral gastroenteritis research and epidemiology
- Hepatitis Viruses Studies and Epidemiology
- Virus-based gene therapy research
- Veterinary medicine and infectious diseases
- Animal Virus Infections Studies
- Liver Disease and Transplantation
- interferon and immune responses
- Respiratory viral infections research
- CRISPR and Genetic Engineering
- Hepatitis C virus research
- Sperm and Testicular Function
- Cancer survivorship and care
- Advanced Differential Geometry Research
- Plant Virus Research Studies
- Influenza Virus Research Studies
- Gastroesophageal reflux and treatments
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- CNS Lymphoma Diagnosis and Treatment
- Ophthalmology and Eye Disorders
- Virology and Viral Diseases
- Reproductive System and Pregnancy
- Vagus Nerve Stimulation Research
- Hypothalamic control of reproductive hormones
- Viral-associated cancers and disorders
Konkuk University
2007-2022
Asan Medical Center
2017
University of Ulsan
2017
Konyang University
2015
Kim's Eye Hospital
2015
Jeju National University
2012
Green Cross (South Korea)
2011
In the past 4 years, incidences of endemic or epidemic respiratory diseases associated with canine influenza H3N2 virus in Asian dogs have been reported countries such as South Korea and China. Canine species were considered to be new natural hosts for this virus. However, at beginning 2010, influenza-like signs, dyspnoea, also observed among cats well an animal shelter located Seoul, Korea. The affected showed 100 % morbidity 40 mortality. We able isolate a from lung specimen dead cat,...
Hepatitis caused by hepatitis E virus (HEV) is a public health concern worldwide. HEV strains have been isolated from several animal species, some of which induce zoonosis. Recently, the isolation rabbits was reported. Here, partial capsid gene (320 bp) detected in rabbit feces via reverse transcriptase-polymerase chain reaction (RT-PCR). Rabbit found two six farms and 17 264 fecal samples (6.4%). A phylogenetic analysis classified isolates into putative clade. full genomic sequence,...
Transgenic chickens, ubiquitously expressing a human protein, could be very useful model system for studying the role of proteins in embryonic development as well efficiently producing pharmaceutical drugs bioreactors. Human parathormone (hPTH) secreted from parathyroid glands plays significant calcium homeostasis and is an important therapeutic agent treatment osteoporosis humans. Here, by using robust replication-defective Moloney murine leukemia virus-based retrovirus vector encapsidated...
Zoonotic transmission of hepatitis E virus (HEV) is mostly mediated by HEV-3 and HEV-4 genotypes, domestic pigs are an important reservoir these genotypes. A survey 14 pig farms in Korea revealed HEV RNA 30 148 (20.3%) fecal samples. HEV-3a HEV-4c subtypes were identified five (35.7%) two (14.3%), respectively. Phylogenetic analysis indicated that the isolated strains closely related to previously reported zoonotic Korea. The results genetic partially explain possible source humans
Hepatitis E virus (HEV) is a quasi-enveloped, positive-sense single stranded RNA virus. HEV continually expands the host ranges across animal species. In this study, possibility of cross-species infection with swine HEV-3 was investigated using rabbits. A total fourteen 8-week old, specific pathogen-free rabbits were divided into three experimental groups. Four used as negative controls, four infected rabbit positive and six inoculated HEV-3. detected from serum fecal samples after viral...
Norovirus is the most common cause of acute gastroenteritis. Its pathogenesis poorly understood owing to difficulty establishing viral infection in animal models. Here, post-weaning gnotobiotic pigs were infected with human norovirus genogroup II genotype 4 (HuNoV GII.4) investigate and replication virus. Three groups four 1 × 10⁵, 10⁶, or 10⁷ genomic equivalent (GE) copies HuNoV GII.4. Four used as negative controls. Blood rectal swab samples collected after infection, gross legions...
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We investigated the cross-species transmission of rabbit hepatitis E virus (rb HEV) to pigs and evaluated cross-protection a swine (sw) HEV-3 virus-like particle (VLP) vaccine against rb HEV infection in pigs. Twelve 4-week-old conventional were divided into negative control (n = 3), positive HEV-infected, n 4), vaccinated (vaccinated HEV-challenged, 5) groups. The was administered at weeks 0 2, viral challenge conducted week 4. Serum RNA, anti-HEV antibody, cytokine, liver enzyme levels...
Torque teno canis virus (TTCaV) is an approximately 2.8 kb circular single-stranded DNA known to cause infections in dogs. However, its incidence Republic of Korea remains unknown. In this study, 135 dog fecal samples were collected determine TTCaV infection status Korea. Based on polymerase chain reaction (PCR) analysis, 13 (9.6%) dogs tested positive for TTCaV. Three full-length genome sequences (GenBank IDs: MZ503910, MZ503911, and MZ503912) obtained from the specimens. Phylogenetic tree...
A human norovirus (HuNoV) strain was obtained from a patient with acute gastroenteritis, and its complete coding sequence determined. The coding-complete viral genome, three open reading frames, 7,565 bp long, GC content of 49.9%. genotype the HuNoV in this study identified as GII.p12_GII.3.
The zoonotic transmission of viral diseases to humans is a serious public health concern. Pigs are frequently major reservoir for several diseases. Therefore, periodic surveillance needed determine the infection rates in domestic pigs. Hepatitis E virus (HEV), rotavirus, sapovirus (SaV), and norovirus (NoV) potential viruses. In this study, 296 fecal samples were collected from weaned piglets growing pigs 13 swine farms, RNA was extracted. Partial genomes amplified by reverse...
Norovirus genogroup II (NoV GII) induces acute gastrointestinal food-borne illness in humans. Because gnotobiotic pigs can be infected with human norovirus (HuNoV) GII, they are frequently used to analyze the associated pathogenic mechanisms and immune responses, which remain poorly understood. Recently, mRNA sequencing analysis (RNA-Seq) has been identify cellular responses viruses. In this study, we investigated host response possible involved virus evasion ileum of HuNoV by RNA-Seq. was...
Urinary tumors include cancers that commonly occur throughout the population, such as bladder cancer, kidney ureter and prostate cancer. The incidence of urological in Korea is increasing. As treatments patients with operation, target therapy, immunotherapy, gene are being developed, life expectancy has been However, significant number experience disease progression despite existing treatments. Therefore, symptom direct treatment crucial oncologic era. Symptoms cancer vary but pain one most...
SARS-CoV-2 induces illness and death in humans by causing systemic infections. Evidence suggests that can induce brain pathology other hosts. In this study, we used a canine transmission model to examine histopathologic changes the brains of dogs infected with SARS-CoV-2. We observed substantial SARS-CoV-2-infected dogs, particularly involving blood-brain barrier damage resembling small vessel disease, including tight junction proteins, reduced laminin levels, decreased pericyte coverage....