A5066601137- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- Animal Disease Management and Epidemiology
- Viral Infections and Immunology Research
- Autoimmune and Inflammatory Disorders Research
- interferon and immune responses
- Macrophage Migration Inhibitory Factor
- Malaria Research and Control
- Research on Leishmaniasis Studies
- Virology and Viral Diseases
- Zoonotic diseases and public health
- Insect symbiosis and bacterial influences
- Virus-based gene therapy research
- Respiratory viral infections research
- Trypanosoma species research and implications
- T-cell and Retrovirus Studies
- Immunotherapy and Immune Responses
- Viral gastroenteritis research and epidemiology
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Rabies epidemiology and control
- Leptospirosis research and findings
- Plant Virus Research Studies
- Vector-Borne Animal Diseases
- Poverty, Education, and Child Welfare
Griffith University
2015-2024
Redland Hospital
2020
Queensland Health
2020
University of Canberra
2011-2016
Applied Science Private University
2011
The University of Western Australia
2005
The Kids Research Institute Australia
2003-2005
Universidad de Costa Rica
1995
Universidad Nacional
1995
ABSTRACT The recent global resurgence of arthritogenic alphaviruses, in particular chikungunya virus (CHIKV), highlights an urgent need for the development therapeutic intervention strategies. While there has been significant progress defining pathophysiology alphaviral disease, relatively little is known about mechanisms involved CHIKV-induced arthritis or potential options to treat severe arthritic symptoms associated with infection. Here, we used microcomputed tomographic (μCT) and...
Significance Persistent polyarthritis, which occurs in 30–40% of alphavirus-infected patients, has been proposed to be caused by proinflammatory mediators such as IL-6. In the present study we investigated susceptibility and response primary human osteoblasts Ross River virus (RRV) infection determined whether could result bone pathology. RRV resulted increased receptor activator nuclear factor-kappaB ligand (RANKL) but decreased osteoprotegerin (OPG). We are first report that alphavirus...
Mosquito-borne alphaviruses such as chikungunya virus and Ross River (RRV) are emerging pathogens capable of causing large-scale epidemics virus-induced arthritis myositis. The pathology RRV-induced disease in both humans mice is associated with induction the host inflammatory response within muscle joints, prior studies have demonstrated that complement system contributes to development disease. In this study, we used a mouse model identify characterize which activation pathways mediate...
Arthrogenic alphaviruses, such as Ross River virus (RRV), chikungunya, Sindbis, mayaro and o'nyong-nyong viruses circulate endemically worldwide, frequently causing outbreaks of polyarthritis. The exact mechanisms how alphaviruses induce polyarthritis remain ill defined, although macrophages are known to play a key role. Macrophage migration inhibitory factor (MIF) is an important cytokine involved in rheumatoid arthritis pathogenesis. Here, we characterize the role MIF alphavirus–induced...
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID are debilitating multisystemic conditions sharing similarities in immune dysregulation cellular signaling pathways contributing to the pathophysiology. In this study, exhaustion gene expression was investigated participants with ME/CFS or concurrently. RNA extracted from peripheral blood mononuclear cells isolated (n = 14), 15), healthy controls 18). Participants were included according Canadian Consensus Criteria....
ABSTRACT Arthritogenic alphaviruses such as Ross River virus (RRV) and chikungunya (CHIKV) cause large-scale epidemics of severe musculoskeletal disease have been progressively expanding their global distribution. Since its introduction in July 2014, CHIKV now circulates the United States. The hallmark alphavirus is crippling pain inflammation joints, a similar immunopathology to rheumatoid arthritis. use glycans novel therapeutics an area research that has increased recent years. Here, we...
Arthrogenic alphaviruses such as Ross River virus (RRV) and chikungunya (CHIKV) circulate worldwide. This class causes debilitating illnesses that are characterized by arthritis, arthralgia, myalgia. In previous studies, we identified macrophage migration inhibitory factor (MIF) a critical inflammatory in the pathogenesis of alphaviral diseases. The present study was undertaken to characterize role CD74, cell surface receptor MIF, both RRV- CHIKV-induced alphavirus arthritides.
ABSTRACT The alphaviral 6k gene region encodes the two structural proteins 6K protein and, due to a ribosomal frameshift event, transframe (TF). Here, we characterized role of in arthritogenic alphavirus Ross River virus (RRV) infected cells and mice, using novel in-frame deletion mutant. Comprehensive microscopic analysis revealed that were predominantly localized at endoplasmic reticulum RRV-infected cells. RRV virions lack TF [RRV-(Δ6K)] more vulnerable changes pH, corresponding had...
The rising prevalence of arthritogenic alphavirus infections, including chikungunya virus (CHIKV) and Ross River (RRV), the lack antiviral treatments highlight potential threat a global pandemic. immune responses underlying virulence remain enigmatic. We found that pentraxin 3 (PTX3) was highly expressed in CHIKV RRV patients during acute disease. Overt expression PTX3 associated with increased viral load disease severity. PTX3-deficient (PTX3(-/-)) mice acutely infected exhibited delayed...
Ross River virus (RRV) is a mosquito-borne prevalent in Australia and the islands of South Pacific, where it causes an arthritogenic illness with hallmark feature severe joint pain. The space unique microenvironment that contains cartilage synovial fluid. Chondrocytes synoviocytes are crucial components known targets RRV infection.
Human respiratory syncytial virus (RSV) is a major cause of morbidity and severe lower tract disease in the elderly very young, with some infants developing bronchiolitis, recurrent wheezing, asthma following infection. Previous studies humans animal models have shown that vaccination formalin-inactivated RSV (FI-RSV) leads to prominent airway eosinophilic inflammation challenge; however, roles pulmonary eosinophilia antiviral response pathogenesis are inadequately understood. In vivo mice...