A5086014138- Respiratory viral infections research
- Influenza Virus Research Studies
- Viral Infections and Vectors
- Bacteriophages and microbial interactions
- Viral Infections and Outbreaks Research
- Genomics and Phylogenetic Studies
- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Virology and Viral Diseases
- Microbial infections and disease research
- COVID-19 epidemiological studies
- Mycobacterium research and diagnosis
- Healthcare Operations and Scheduling Optimization
- Emergency and Acute Care Studies
- Pneumonia and Respiratory Infections
- Health Systems, Economic Evaluations, Quality of Life
- Mosquito-borne diseases and control
- Hepatitis B Virus Studies
Queen Elizabeth University Hospital
2019-2021
National Health Service
2020
Glasgow Royal Infirmary
2019
NHS Greater Glasgow and Clyde
2019
MRC University of Glasgow Centre for Virus Research
2015-2016
Public Health England
2016
University of Glasgow
2015
The human respiratory tract hosts a diverse community of cocirculating viruses that are responsible for acute infections. This shared niche provides the opportunity virus-virus interactions which have potential to affect individual infection risks and in turn influence dynamics at population scales. However, quantitative evidence has lacked suitable data appropriate analytical tools. Here, we expose quantify among using bespoke analyses time series scale coinfections host scale. We analyzed...
Molecular assays are the gold standard methods used to diagnose viral respiratory pathogens. Pitfalls associated with this technique include limits number of targeted pathogens, requirement for continuous monitoring ensure sensitivity/specificity is maintained and need evolve emerging Introducing target independent next generation sequencing (NGS) could resolve these issues revolutionise diagnostics.To compare sensitivity specificity NGS against current diagnostic test.Diagnostic RT-PCR...
Zika virus RNA has been detected in semen collected several months after onset of symptoms infection. Given the potential for sexual transmission and serious fetal abnormalities resulting from infection during pregnancy, information regarding persistence is critical advancing our understanding risks. We tested serial samples symptomatic male patients United Kingdom who had a diagnosis imported Among initial 23 patients, was at high levels 13 (56.5%) not 9 (39.1%); detection indeterminate 1...
Viral respiratory infections continue to pose a major global healthcare burden. At the community level, co-circulation of viruses is common and yet studies generally focus on single aetiologies. We conducted first comprehensive epidemiological analysis encompass all in population. Using extensive multiplex PCR diagnostic data generated by largest NHS board Scotland, we analysed 44230 patient episodes illness that were simultaneously tested for 11 virus groups between 2005 2013, spanning 2009...
Abstract Background In October 2015, 65 people came into direct contact with a healthcare worker presenting late reactivation of Ebola virus disease (EVD) in the United Kingdom. Vaccination was offered to 45 individuals an initial assessment high exposure risk. Methods Approval for rapid expanded access recombinant vesicular stomatitis virus–Zaire (rVSV-ZEBOV) vaccine as unlicensed emergency medicine obtained from relevant authorities. An observational follow-up study carried out 1 year...
Abstract High-throughput sequencing (HTS) enables most pathogens in a clinical sample to be detected from single analysis, thereby providing novel opportunities for diagnosis, surveillance, and epidemiology. However, this powerful technology is difficult apply diagnostic laboratories because of its computational bioinformatic demands. We have developed DisCVR, which detects known human viruses samples by matching k-mers (twenty-two nucleotide sequences) taxonomically labeled viral genomes....
ABSTRACT The 4C Mortality Score (4C Score) was designed to risk stratify hospitalised patients with COVID-19. We assessed inclusion of in COVID-19 management guidance and its documentation patients’ case notes January 2021 UK hospitals. included within by 50% sites, though score highly variable. Higher associated integration admissions proformas, variables or link online calculator, decisions. Integration clinical pathways may encourage more widespread use.