A5057669566- Immunotherapy and Immune Responses
- Tuberculosis Research and Epidemiology
- Hepatitis B Virus Studies
- Mycobacterium research and diagnosis
- Aortic aneurysm repair treatments
- vaccines and immunoinformatics approaches
- Viral Infections and Outbreaks Research
- SARS-CoV-2 and COVID-19 Research
- Cancer Immunotherapy and Biomarkers
- Food Security and Health in Diverse Populations
- Cytomegalovirus and herpesvirus research
- Prostate Cancer Treatment and Research
- Virus-based gene therapy research
- Diagnosis and treatment of tuberculosis
- Immune responses and vaccinations
- CAR-T cell therapy research
- Immune Response and Inflammation
- Immunodeficiency and Autoimmune Disorders
- Infectious Diseases and Tuberculosis
- Homelessness and Social Issues
- Influenza Virus Research Studies
- Hepatitis C virus research
- Cardiac, Anesthesia and Surgical Outcomes
- Medical Coding and Health Information
- Urban Agriculture and Sustainability
Vaccitech (United Kingdom)
2017-2023
University of Arizona
2021-2022
University of Baltimore
2021
Aeras
2012-2019
Queen Elizabeth University Hospital
2019
Royal Gwent Hospital
2016-2018
Royal Glamorgan Hospital
2015-2016
Cardiff Metropolitan University
2016
West Midlands Deanery
2016
Breast Cancer Care
2015
Tuberculosis (TB) is the leading cause of infectious death worldwide. Development improved TB vaccines that boost or replace BCG a major global health goal. ID93 + GLA-SE fusion protein vaccine candidate combined with Toll-like Receptor 4 agonist adjuvant, GLA-SE. We conducted phase 1, randomized, double-blind, dose-escalation clinical trial to evaluate two dose levels antigen, administered intramuscularly alone in combination 60 BCG-naive, QuantiFERON-negative, healthy adults US...
There are a limited number of adjuvants that elicit effective cell-based immunity required for protection against intracellular bacterial pathogens. Here, we report STING-activating cyclic dinucleotides (CDNs) formulated in protein subunit vaccine long-lasting protective to Mycobacterium tuberculosis the mouse model. Subcutaneous administration this provides equivalent live attenuated strain Bacille Calmette-Guérin (BCG). Protection is STING dependent but type I IFN independent and...
Background:The coronavirus disease 2019 (COVID-19) pandemic profoundly affected food systems including security.Understanding how the COVID-19 impacted security is important to provide support and identify long-term impacts needs.Objective: The National Food Access COVID research Team (NFACT) was formed assess over different US study sites throughout pandemic, using common instruments measurements.This presents results from 18 across 15 states nationally first year of pandemic.Methods: A...
BackgroundTuberculosis is the leading single-pathogen cause of death worldwide, and China has third largest number cases worldwide. New tools, such as new vaccines, are needed to meet WHO tuberculosis goals. Tuberculosis vaccine development strategies mostly target infants or adolescents, but given China's ageing epidemic, vaccinating older people might be important. We modelled potential impact vaccines in targeting adolescents (15–19 years) adults (60–64 with varying characteristics inform...
Chronic hepatitis B virus (HBV) infection affects 257 million people globally. Current therapies suppress HBV but viral rebound occurs on cessation of therapy; novel therapeutic strategies are urgently required. To develop a vaccine that can induce high magnitude T cells to all major antigens, we have developed using chimpanzee adenovirus (ChAd) and modified vaccinia Ankara (MVA) vectors encoding multiple antigens. ChAd alone generated very specific cell responses The inclusion shark...
A new type of clinical summary, produced by copying standard descriptions diseases on to a computer screen and editing them match patient9s findings diagnoses, was updated reprinted as the condition changed in ward or an outpatient. When this method used produce typed medical discharge summaries over three month period, 73 out 91 (80%) were sent within week after compared with five 56 (9%) conventionally received single general practice. Even completely computerised are quicker for secretary...
Abstract The development of a vaccine for Mycobacterium tuberculosis (Mtb) has been impeded by the absence correlates protective immunity. One correlate would be ability cells induced vaccination to recognize Mtb-infected cell. AERAS-402 is replication-deficient serotype 35 adenovirus containing DNA expressing fusion protein Mtb antigens 85A, 85B and TB10.4. We undertook phase I double-blind, randomized placebo controlled trial with following BCG. Analysis vaccine-induced immune response...
Abstract Background In October 2015, 65 people came into direct contact with a healthcare worker presenting late reactivation of Ebola virus disease (EVD) in the United Kingdom. Vaccination was offered to 45 individuals an initial assessment high exposure risk. Methods Approval for rapid expanded access recombinant vesicular stomatitis virus–Zaire (rVSV-ZEBOV) vaccine as unlicensed emergency medicine obtained from relevant authorities. An observational follow-up study carried out 1 year...
Although it is now recognised as a rare complication of cardiac surgery, constrictive pericarditis was diagnosed in three patients after coronary artery bypass surgery. The time interval between surgery and the development features varied from two to six weeks. All presented with severe congestive heart failure. Haemodynamic findings were characteristic pericarditis. Pericardial thickening detected by computed tomography one patient useful establishing definite diagnosis. One had serous...
Despite the success of vaccines in reducing morbidity and mortality associated with infectious diseases, many both newly emerging well known, lack vaccines. The global capability for beginning‐to‐end vaccine development has become limited, primarily owing to a scarcity human capital necessary guide novel from laboratory marketplace. Here, we identify discuss gaps robust make recommendations begin address these deficiencies.
New Findings What is the central question of this study? To what extent focal abdominal aortic aneurysmal (AAA) disease associated with systemic remodelling vascular tree remains unknown. The present study examined whether anatomical differences exist between distances intervisceral artery origins and AAA location/size in patients compared healthy patients. main finding its importance? Intervisceral were shown to be consistently greater patients, highlighting nature that extends proximally...
3018 Background: Prostate cancer (PCa) has been under investigation as a target for antigen-specific immunotherapies in metastatic disease settings. However, neither of the two clinically most advanced PCa vaccines, Sipuleucel-T and ProstVac, induced strong T cell immunity. In our study, we evaluated novel vaccination platform based on replication-deficient viruses, chimpanzee adenovirus MVA, targeting an oncofetal self-antigen 5T4 early stage PCa. Methods: 40 patients, either newly...
Pseudoaneurysms of the subclavian artery remain a rare complication after fracture clavicle. We report case delayed diagnosis pseudoaneurysm closed clavicle in 15-year-old patient, 3 months original injury while playing rugby union. Despite several attendances to Emergency Department with vague symptoms, final was confirmed by duplex ultrasound and Computed Tomography thorax. Surgical repair indicated due acute limb ischaemia from distal embolisation large pseudoaneurysm, patient making full...
Abstract Background The COVID-19 pandemic profoundly affected food systems including security. Understanding how the impacted security is important to provide support, and identify long-term impacts needs. Objective Our team- National Food Access COVID research Team (NFACT) was formed assess over different U.S. study sites throughout pandemic, using common instruments measurements. Here we present results from 18 across 15 states nationally first year of pandemic. Methods A validated survey...