A5036442267- Insect symbiosis and bacterial influences
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Parasitic Diseases Research and Treatment
- Genomics and Phylogenetic Studies
- Genetic diversity and population structure
- Insect behavior and control techniques
- Orthoptera Research and Taxonomy
- CRISPR and Genetic Engineering
Edinburgh Genomics
2023
University of Edinburgh
2023
University of York
2023
The University of Queensland
2022
The Pirbright Institute
2020-2022
Ludwig-Maximilians-Universität München
2020
Genetic pest management (GPM) methods involve releasing modified versions of a species to mate with wild pests in the target area. Proposed for wide range applications public health, agriculture and conservation, most progress has been made insects. Offspring released insects carry modification—which might be transgenes, artificially introduced Wolbachia or genetic damage from radiation, example—but they also complete haploid genome their laboratory-reared parent, as well one parent. Unless...
Biological control of mosquito vectors using the endosymbiotic bacteria Wolbachia is an emerging strategy for management human arboviral diseases. We recently described development a strain Aedes aegypti infected with wAlbB (referred to as wAlbB2-F4 strain) through simple backcrossing wild type Australian mosquitoes Ae. from USA. Field releases male resulted in successful suppression populations trial sites by exploiting strain's Wolbachia-induced cytoplasmic incompatibility. now demonstrate...
Multiple viruses, including pathogenic bacteriophages, and even plant cause a phenomenon termed superinfection exclusion whereby currently infected cell is resistant to secondary infection by the same or closely related virus. In alphaviruses, this process thought be mediated, at least in part, viral protease (nsP2) which responsible for processing nonstructural polyproteins (P123 P1234) into individual proteins (nsP1-nsP4), forming replication complex. Taking synthetic biology approach, we...
The barcoding of the mitochondrial COX1 gene has been instrumental in cataloguing tree life, and providing insights phylogeographic history species. Yet, this strategy encountered difficulties major clades characterized by large genomes, which contain a high frequency nuclear pseudogenes originating from genome (numts). Here, we use meadow grasshopper (Chorthippus parallelus), possesses giant ~13 Gb, to identify genes that are underrepresented as numts, test their informative markers. We...
ABSTRACT Biological control of mosquito vectors using the insect-specific bacteria Wolbachia is an emerging strategy for management human arboviral diseases. We recently described development a strain Ae. aegypti infected with w AlbB (referred to as AlbB2-F4 strain) through simple backcrossing wild type Australian mosquitoes from USA. Field releases male resulted in successful suppression population trial sites by exploiting strains Wolbachia- induced cytoplasmic incompatibility. now...
Abstract Multiple viruses cause a phenomenon termed superinfection exclusion whereby currently infected cell is resistant to secondary infection by the same or closely related virus. In alphaviruses, this process thought be mediated, at least in part, viral protease (nsP2) which responsible for processing non-structural polyproteins (P123 and P1234) into individual proteins (nsP1-nsP4), forming replication complex. Taking synthetic-biology approach, we mimicked naturally occurring generating...