A5040362081- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Advanced NMR Techniques and Applications
- Atomic and Subatomic Physics Research
- Electron Spin Resonance Studies
- Medical Imaging Techniques and Applications
- Cardiovascular Disease and Adiposity
- Radiomics and Machine Learning in Medical Imaging
- Advanced Neuroimaging Techniques and Applications
- Cardiovascular Health and Disease Prevention
- NMR spectroscopy and applications
- Lanthanide and Transition Metal Complexes
- Cardiac Arrhythmias and Treatments
- MRI in cancer diagnosis
- Cardiac Structural Anomalies and Repair
- Cardiomyopathy and Myosin Studies
- Liver Disease Diagnosis and Treatment
- Osteoarthritis Treatment and Mechanisms
- Congenital Heart Disease Studies
- Ultrasound and Hyperthermia Applications
- Genetic Associations and Epidemiology
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
University of Pennsylvania
2016-2025
California University of Pennsylvania
2014-2025
Farm Foundation
2023
Hospital of the University of Pennsylvania
2011-2022
Philadelphia University
2018-2021
Bridgewater College
2020
Longwood University
2018-2019
University of Kentucky
2016
National Heart Lung and Blood Institute
2016
National Institutes of Health
2016
Purpose To prospectively determine the reproducibility of quantitative magnetic resonance (MR) imaging biomarkers morphology and composition (spin lattice relaxation time in rotating frame [T1-ρ], T2) knee cartilage a multicenter multivendor trial involving patients with osteoarthritis (OA) asymptomatic control subjects. Materials Methods This study was HIPAA compliant approved by institutional review committees participating sites, written informed consent obtained from all participants....
A novel synthesis of dextran coated bismuth–iron oxide nanoparticles (BION) is reported. They are found to be effective as contrast agents for both CT and MRI biodegradable biocompatible.
Injectable, acellular biomaterials hold promise to limit left ventricular remodeling and heart failure precipitated by infarction through bulking or stiffening the infarct region. A material with tunable properties (eg, mechanics, degradation) that can be delivered percutaneously has not yet been demonstrated. Catheter-deliverable soft hydrogels in vivo enhance therapeutic efficacy achieve these requirements.We developed a hyaluronic acid hydrogel uses tandem crosslinking approach, where...
<b>BACKGROUND AND PURPOSE:</b> There is significant interest in the development of novel noninvasive techniques for diagnosis Alzheimer disease (AD) and tracking its progression. Because MR imaging has detected alterations sodium levels that correlate with cell death stroke, we hypothesized there would be brains patients AD, related to AD death. <b>MATERIALS METHODS:</b> A total 10 volunteers (5 mild 5 healthy control subjects) were scanned a 20-minute (<sup>23</sup>Na) protocol on 3T...
Late gadolinium enhanced (LGE) cardiovascular magnetic resonance (CMR) is frequently used to evaluate myocardial viability, estimate total infarct size and transmurality, but not always straightforward contraindicated in patients with renal failure because of the risk nephrogenic systemic fibrosis. T2- T1-weighted CMR alone however relatively insensitive chronic infarction (MI) absence a contrast agent. The objective this manuscript explore T1ρ-weighted rotating frame techniques for...
AION have improved biocompatibility and are an effective multimodal contrast agent for breast cancer diagnosis.
BACKGROUNDTwo coding alleles within the APOL1 gene, G1 and G2, found almost exclusively in individuals genetically similar to West African populations, contribute substantially pathogenesis of chronic kidney disease (CKD). The APOL gene cluster on chromosome 22 contains a total 6 genes that have arisen as result duplication.METHODSUsing genome-first approach Penn Medicine BioBank, we identified 62 protein-altering variants with minor allele frequency >0.1% population participants reference...
Abstract Restoration of coronary blood flow after a heart attack can cause reperfusion injury potentially leading to impaired cardiac function, adverse tissue remodeling and failure. Iron is an essential biometal that may have pathologic role in this process. There clinical need for precise noninvasive method detect iron risk stratification patients therapy evaluation. Here, we report magnetic susceptibility imaging large animal model shows infarct paramagnetic shift associated with duration...
Abstract Purpose To develop a T1ρ‐prepared, balanced gradient echo (b‐GRE) pulse sequence for rapid three‐dimensional (3D) T1ρ relaxation mapping within the time constraints of clinical exam (<10 minutes), examine effect acquisition on measured and optimize 3D sequences knee joint spine. Materials Methods A consisting inversion recovery–prepared, fat saturation, T1ρ‐preparation, b‐GRE image was used to obtain volume coverage patellofemoral tibiofemoral cartilage lower lumbar Multiple...
In Brief Study Design. This study demonstrated the diagnostic potential of sodium (Na) magnetic resonance imaging (MRI) for noninvasive quantification proteoglycan (PG) in intervertebral discs. Objective. To determine existence a linear correlation between disc [Na] measured from MRI and [PG] measurement DMMB assay. Summary Background Data. Previous studies have shown possibility quantifying Na vivo using MRI, however, none has direct invertebral Methods. Three-dimensional images bovine...
Abstract Nine asymptomatic subjects and six patients underwent T 1 ρ MRI to determine whether Outerbridge grade or 2 cartilage degeneration observed during arthroscopy could be detected noninvasively. was performed 2‐3 months postarthroscopy, using sagittal ‐weighted axial coronal MRI, from which spatial relaxation maps were calculated segmented images. Median times of with arthroscopically documented significantly different ( P < 0.001), median exceeded articular by 2.5 9.2 ms. In eight...
Abstract T1ρ relaxation times were quantified in a swine model of chronic, left ventricular myocardial infarction. It was found that there low frequency mechanisms suppress endogenous contrast at spin‐lock amplitudes and T2‐weighted images. A moderate amplitude spin‐locking pulse could overcome these mechanisms. Relaxation dispersion data measured over range RF field amplitudes, formulated to include dipole–dipole modulated by molecular rotation an apparent exchange mechanism. These...
Introduction Right ventricular (RV) function has increasingly being recognized as an important predictor for morbidity and mortality in patients with pulmonary arterial hypertension (PAH). The increased RV after-load increase work PAH. We used time-resolved 3D phase contrast MRI (4D flow MRI) to derive kinetic energy (KE) density loss the artery (PA) better characterize PAH patients. Methods 4D standard cardiac cine images were obtained ten functional class I/II nine healthy subjects. For...