A5005152513- Cardiac Valve Diseases and Treatments
- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Cardiac Structural Anomalies and Repair
- Infective Endocarditis Diagnosis and Management
- Infectious Aortic and Vascular Conditions
- Intracranial Aneurysms: Treatment and Complications
- Cardiovascular Function and Risk Factors
- Hepatitis C virus research
- Vascular Malformations Diagnosis and Treatment
- Cardiac and Coronary Surgery Techniques
- Electrospun Nanofibers in Biomedical Applications
- Vascular Procedures and Complications
- Brain Metastases and Treatment
- Neurofibromatosis and Schwannoma Cases
- Cardiovascular Disease and Adiposity
- Head and Neck Surgical Oncology
- Cerebrospinal fluid and hydrocephalus
- Peripheral Artery Disease Management
- Cardiovascular Health and Disease Prevention
- Cardiac, Anesthesia and Surgical Outcomes
- Tissue Engineering and Regenerative Medicine
- Abdominal vascular conditions and treatments
Oita University
2016-2025
Oita University Hospital
2013-2024
Yokohama Rosai Hospital
2004-2024
Osaka Metropolitan University
2023
Osaka City University
2000-2021
Stanford Medicine
2021
Osaka Rosai Hospital
2016
University of Pennsylvania
2011-2013
NIHR Leeds Musculoskeletal Biomedical Research Unit
2013
University of Leeds
2013
Background Manifestations of reperfusion injury include myocyte death leading to infarction, contractile dysfunction, and vascular characterized by the “no‐reflow” phenomenon. Mitochondria‐produced reactive oxygen species are believed be centrally involved in each these aspects injury, although currently no therapies reduce targeting mitochondria specifically. Methods Results We investigated cardioprotective effects a mitochondria‐targeted peptide, Bendavia (Stealth Peptides), across...
Abstract Background Interferon therapy seems to decrease the incidence of recurrence after resection hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC). Effects postoperative interferon on survival rate such HCC are still unclear. Methods A prospective randomized clinical trial was performed. Thirty men were allocated randomly liver an interferon-α group (15 patients) or a control group. Patients in received 6 MIU intramuscularly every day for 2 weeks, then three times week 14...
Late gadolinium enhanced (LGE) cardiovascular magnetic resonance (CMR) is frequently used to evaluate myocardial viability, estimate total infarct size and transmurality, but not always straightforward contraindicated in patients with renal failure because of the risk nephrogenic systemic fibrosis. T2- T1-weighted CMR alone however relatively insensitive chronic infarction (MI) absence a contrast agent. The objective this manuscript explore T1ρ-weighted rotating frame techniques for...
Sodium-glucose cotransporter 2 (SGLT2) inhibitors reduce epicardial adipose tissue (EAT) in humans, enhancing cardioprotective effects on heart failure and atrial fibrillation. We investigated the direct effect of SGLT2 inhibitor empagliflozin human primary adipocytes preadipocytes. is primarily expressed preadipocytes EAT. The expression levels significantly diminished when were terminally differentiated. Adipogenesis was attenuated by treatment without affecting cell proliferation....
Percutaneous transhepatic portal vein embolization (PTPE) increases the safety of subsequent major hepatectomy. The aim this study was to determine effect PTPE on long-term prognosis after hepatectomy in patients with hepatocellular carcinoma (HCC).Seventy-one HCC underwent right between 1984 and 1998. Preoperative performed 33 (group 1) not used 38 2). Outcome operation compared groups. were further divided according median tumour diameter (cut-off 6 cm) indocyanine green retention rate at...
This study investigated the long-term patency of regenerative Biotube grafts and discusses their feasibility as an alternative to autologous vein for peripheral artery disease. Six Biotubes with a diameter 4 mm were autologously fabricated in recipients using vivo tissue engineering (in-body architecture) technology implanted carotid bypass goat model. All six remained patent at 6 months despite exceeding 10 cm length, demonstrating biocompatibility durability. Histological analysis revealed...
Abstract Background A 34-year-old woman at 25 gestational weeks presented with severe respiratory distress secondary to heart failure caused by mitral regurgitation and infective endocarditis. Case presentation Transthoracic echocardiography revealed a large (17 mm) vegetation attached the posteromedial commissure of valve leaflet. Owing pulmonary edema circulatory failure, she underwent emergency cesarean section improve maternal hemodynamics. Postoperatively, her resolved, hemodynamic...
A 51-year-old female patient presented with abdominal distension. Computed tomography revealed a right ovarian tumor suspicious for clinical stage IC cancer, along considerable inferior vena cava (IVC) thrombus extending to the Th2 level, accompanied by deep vein and peripheral left pulmonary embolism (PE). Preoperative IVC filter placement was deemed unfavorable due short distance between renal thrombus. On second day of hospitalization, extraction, thrombectomy, were performed. Pathology...
Using an electrochemiluminescence immunoassay, CYFRA 21-1 concentrations were measured in sera from 187 patients with primary liver cancer (164 hepatocellular carcinoma (HCC) and 23 intrahepatic cholangiocarcinoma (ICC)) 87 benign diseases. Concentrations of significantly higher ICC (5.0; interquartile range 3.1–10.7 ng ml−1) than those disease (1.4; 1.0–1.9; Mann–Whitney U-test, P<0.0001) or HCC (1.7; 1.1–2.7; P<0.0001). cutoff values selected for 95% specificity the group (3.0 ml−1),...
Fibrotic remodeling of epicardial adipose tissue (EAT) is crucial for proinflammatory atrial myocardial fibrosis, which leads to fibrillation (AF).We tested the hypothesis that ratio central marginal adipocyte diameter in EAT represents its fibrotic remodeling. Based on a similar concept, we also whether percent (%) change fat attenuation determined using computed tomographic (CT) images can detect this remodeling.Left appendages were obtained from 76 consecutive AF patients during...
Objectives: Ischemic mitral regurgitation results from annular dilatation, leaflet tethering and flattening. Undersized annuloplasty corrects dilatation but worsens This exacerbation of abnormal geometry may contribute to poor repair for ischemic (IMR). Using a sheep model IMR, we hypothesized that posterior augmentation less-extreme undersizing would relieve increase curvature. Methods: Eight weeks after posterolateral infarct, 10 with ≥2+ IMR underwent either 24-mm planar ring (n = 5) or...
Background— Transannular patch (TAP) repair of tetralogy Fallot often results in significant right ventricular outflow tract (RVOT) dilation and distortion. We hypothesized that insertion Melody valves into the proximal left branch pulmonary arteries (PAs) would reduce regurgitation fraction (PRF) an ovine model insufficiency dilated RVOT. Methods Results— Ten sheep underwent baseline cardiac catheterization, surgical valvectomy, TAP placement. A subset (n=5) had (2 devices per animal)...
Biotubes are autologous tubular tissues developed within a patient’s body through in-body tissue architecture, and they demonstrate high potential for early clinical application as vascular replacement. In this pilot study, we used large animals to perform implantation experiments in preparation preclinical testing of Biotube. The biological response after Biotube was histologically evaluated. designed (length: 50 cm, internal diameter: 4 mm, wall thickness: 0.85 mm) were obtained by...
Hypothesizing that combined hepatocellular and intrahepatic cholangiocellular carcinoma originates from hepatic stem cells, we conducted a series of immunohistochemical studies using cell markers to better understand the origin tumor. Specially, investigated 15 tumors confirmed be immunoreactive anti-hepatocyte paraffin 1, anti-cytokeratin 7 19 antibodies. Macroscopic investigation revealed cancer cells morphologically intermediate between neoplastic hepatocytes cholangiocytes (combined...
Object The combination approach of Ommaya reservoir placement and Gamma Knife surgery (GKS) was evaluated for the treatment large cystic metastatic brain tumors. Methods medical records 22 patients harboring 28 tumors, who underwent followed by GKS tumors were retrospectively reviewed. patients' ages ranged 26 to 77 years (mean 57.1 years). most common locations primary malignancy breast (11 patients) lung (seven patients). mean maximum diameter tumor 40.1 mm before 31.2 at reduction 19.9%)....