A5009406005- Aortic Disease and Treatment Approaches
- Electrospun Nanofibers in Biomedical Applications
- Cardiac Valve Diseases and Treatments
- Cardiac and Coronary Surgery Techniques
- Aortic aneurysm repair treatments
- Peripheral Artery Disease Management
- Infectious Aortic and Vascular Conditions
- Infective Endocarditis Diagnosis and Management
- Tissue Engineering and Regenerative Medicine
- Cardiac, Anesthesia and Surgical Outcomes
- Vascular Procedures and Complications
- Intracranial Aneurysms: Treatment and Complications
- Coronary Artery Anomalies
- Cardiac Structural Anomalies and Repair
- Takotsubo Cardiomyopathy and Associated Phenomena
- Mechanical Circulatory Support Devices
- Diabetic Foot Ulcer Assessment and Management
- 3D Printing in Biomedical Research
- Vascular anomalies and interventions
- Pericarditis and Cardiac Tamponade
- Cardiac tumors and thrombi
- Myasthenia Gravis and Thymoma
- Neurofibromatosis and Schwannoma Cases
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Hemostasis and retained surgical items
Oita University
2015-2025
Oita University Hospital
2017-2024
Almeida Memorial Hospital
2024
Isesaki Municipal Hospital
2019
Isesaki Fukushima Hospital
2019
This study investigated the long-term patency of regenerative Biotube grafts and discusses their feasibility as an alternative to autologous vein for peripheral artery disease. Six Biotubes with a diameter 4 mm were autologously fabricated in recipients using vivo tissue engineering (in-body architecture) technology implanted carotid bypass goat model. All six remained patent at 6 months despite exceeding 10 cm length, demonstrating biocompatibility durability. Histological analysis revealed...
Histologic evaluations revealed excessive accumulations of macrophages and absence fibroblastic interstitial cells in explanted bioprosthetic valves. Comprehensive gene protein expression analysis histology unveiled an accumulation fibrinogen plasminogen, activator infiltrated macrophages, from degenerated valve surfaces the spaces. These pathologies were completely reproduced a goat model replaced with autologous pericardium-derived aortic valve. Further preclinical animal experiments using...
This study investigated six-month outcomes of first models ascending aortic replacement. The molds used to produce the Biotube were implanted subcutaneously in goats. After 2–3 months, explanted obtain Biotubes (inner diameter, 12 mm; wall thickness, 1.5 mm). Next, we performed replacement using five allogenic At 6 animals underwent computed tomography (CT) and histologic evaluation. As a comparison, similar surgeries glutaraldehyde-fixed autologous pericardial rolls or pig-derived...
Biotubes are autologous tubular tissues developed within a patient’s body through in-body tissue architecture, and they demonstrate high potential for early clinical application as vascular replacement. In this pilot study, we used large animals to perform implantation experiments in preparation preclinical testing of Biotube. The biological response after Biotube was histologically evaluated. designed (length: 50 cm, internal diameter: 4 mm, wall thickness: 0.85 mm) were obtained by...
Abstract OBJECTIVES Aortic valve neocuspidization has shown satisfactory clinical outcomes; however, autologous pericardium durability is a concern for young patients. This study applied an collagenous membrane (Biosheet®), produced by in-body tissue architecture, to aortic and investigated its long-term outcome in goat model. METHODS Moulds were embedded subcutaneously 6 goats. After 2 months, Biosheets formed the moulds. We performed using portion of sheets with thickness 0.20–0.35 mm,...
Abstract There are no small‐diameter, long artificial vascular grafts for below‐knee bypass surgery in chronic limb‐threatening ischemia. We have developed tissue‐engineered called “Biotubes®” using a completely autologous approach in‐body tissue architecture (iBTA). This study aimed at pre‐implantation evaluation of Biotube and its vivo preparation device, Maker, use surgery. Forty nine makers were subcutaneously embedded into 17 goats predetermined periods (1, 2, or 3 months). All produced...
There is a need for small diameter vascular substitutes in the absence of available autologous material. A diameter, long tissue engineered graft was developed using completely approach called "in body architecture technology (iBTA)". The aim this pilot study to evaluate "Biotubes", iBTA induced collagenous tubes, their potential use as bypass conduits.Biotubes (internal 4 mm, length 50 cm, wall thickness 0.85 mm) were prepared by subcutaneous embedding plastic moulds (Biotube Maker) three...
Blood access is a lifeline for dialysis patients. However, serious problems such as stenosis or obstruction of blood vessels, which are life-threatening conditions in daily clinical practice, still remain. One the most promising candidates solving these may be Biotube vessels. More than 20 years have passed since development in-body tissue architecture (iBTA), technology preparing tissues autologous implantation The obtained by iBTA do not elicit immunological rejection, one ultimate goals...
症例は72歳の男性.20年前に検診異常で診断された大動脈弁閉鎖不全症を近医で加療中に,下腿浮腫,体重増加でおおよそ2カ月間内服加療が行われるも症状の改善なく,当院の心臓超音波検査による精査で,無冠状動脈洞に生じたValsalva洞動脈瘤破裂,右房穿破の診断に至った.手術は発症から2カ月半後に待機的に計画され,人工心肺使用下に大動脈弁側と右房側の両側からのアプローチでパッチによる瘻孔閉鎖と,無冠尖の弁尖形態の変性による大動脈弁閉鎖不全症に対しては大動脈弁置換術で手術を完遂し,術後経過良好で術後14日目に自宅退院された.元来,左右シャントを形成し,重篤な心不全症状で発症することもある破裂性Valsalva洞動脈瘤は非常に稀な疾患である.発症機序は,先天的なValsalva洞の組織脆弱性が原因とされ,破裂に至る症例は40歳代ごろまでの比較的若年層であることが一般的である.本症例は72歳という高齢発症であり,さらに急激な心不全症状の進行なく,待機手術が可能であった非常に稀有な経過を辿った症例として,文献的考察も含め報告する.
Autologous pericardium is widely used as a plastic material in intracardiac structures, the pulmonary artery, and aortic valve leaflets. For reconstruction (AVRec) using Ozaki procedure, it has produced excellent clinical results over 10-year period. In-body tissue architecture (iBTA), which based on phenomenon of encapsulation foreign materials, can be to prepare autologous prosthetic tissues. In this preliminary study, we examined whether biosheets leaflet for glutaraldehyde-free AVRec by...
左室内血栓症は，急性心筋梗塞後もしくは心筋症や重症弁膜症などによる低左心機能症例に合併するが，可動性血栓の場合や塞栓症の既往がある場合，さらに心機能が改善傾向にある場合などは積極的外科手術の適応となる．今回，急性心筋梗塞後に左室心尖部血栓を生じた1例と，うっ血性心不全治療中に左室心尖部血栓を生じた1例に対して，右第4肋間から，完全内視鏡下に経左房・経僧帽弁アプローチで外科的血栓除去術を行い，良好な結果を得たので報告する．
We describe a 54-year-old man with neurofibromatosis type 1 who presented left-sided neck mass. Computed tomography demonstrated left common carotid artery aneurysm (51 × 33 mm). Surgery was performed because of the risk rupture. The found to be huge aneurysmal dilatation, and arterial wall partially collapsed extensively adherent surrounding tissues. Left internal bypass grafting reversed saphenous vein graft. Histopathological examination revealed vascular fragility wall.
The reconstruction of the aortic valve using glutaraldehyde-treated autologous pericardium is known as “aortic neo-cuspidization” (AVNeo). In-body tissue architecture (iBTA), a cell-free, in vivo tissue-engineering that can produce implantable tissues desired shape by subcutaneously embedding specially designed molds, was used to develop sheet-like collagenous called “Biosheets.” Cylindrical molds with line slits arranged an alternating (n=30) or parallel (n=36) pattern were embedded goats...
症例は66歳，女性．幼少期より左下肢の過成長傾向を認め，20歳台から浮腫や血栓性静脈炎などの静脈うっ滞症候群を繰り返していた．56歳時のCT検査で左外腸骨動脈瘤とリンパ管および静脈奇形を指摘され，今回66歳で左鼠径部の皮下腫瘤増大と同側股関節可動制限を自覚したため，精査加療目的で当科紹介となった．術前精査では，リンパ管および静脈奇形を主とする混合型血管奇形を合併した左外腸骨動脈瘤を認めた．左総腸骨動脈から下肢末梢動脈の拡張蛇行を認め，今回は破裂の危険性が高い直径43mmの外腸骨動脈瘤を治療対象とした．リンパ管および静脈奇形が左下腹部体壁から後腹膜にかけてびまん性に存在するため開腹瘤切除術は困難と判断し，浅大腿動脈アプローチのステントグラフト内挿術を施行した．術後は問題なく経過し，第7病日に退院となり，初回外来CT検査でもendoleak無く経過した．
症例1，67歳女性．劇症型心筋炎に対してbridge to recovery目的に両心補助人工心臓装着術を施行した．術前に中等度大動脈弁逆流を認め，生体弁（CEP Magna Ease 21 mm）による大動脈弁置換術を併施した．心機能の回復が得られたため，術後180日目に左心補助人工心臓離脱術を行った．補助人工心臓抜去後の体外循環離脱に際し，高度の左心機能低下を認め体外循環離脱困難に陥った．経食道心臓超音波で生体弁の高度狭窄が判明した．再度心停止．大動脈弁位の生体弁は，左室側から増生したパンヌスにより弁尖が癒合し高度狭窄の所見を呈した．パンヌスの剥離・除去により生体弁機能は回復し，体外循環から容易に離脱可能となった．症例2，68歳女性．劇症型心筋炎に対して両心補助人工心臓装着術および大動脈弁置換術（CEP 19...
Streptococcus suis is a zoonotic pathogen that causes invasive infections in humans. We report case of aortic and tricuspid valve infective endocarditis caused by suis, which required cardiac surgery. The patient was 53-year-old man with high fever general fatigue for one month. He had been pig farmer 30 years. His blood cultures were positive transthoracic echocardiography revealed regurgitation mobile vegetations adhering to the valve. performed neo-cuspidization using autologous...
症例は70歳の女性．脳出血による右片麻痺のため長期臥床状態，日常生活動作は全介助の状態であった．4年前に肺塞栓症で外科的血栓除去術を施行された．1年前に心不全症状があり，前医にて収縮性心膜炎と診断され，薬物治療をされていた．今回，発熱を主訴に前医を受診し，心エコーで心嚢液貯留を認め，心タンポナーデを疑われ当科紹介入院となった．心嚢穿刺ドレナージで膿性の排液があり，化膿性心外膜炎の診断となった．膿瘍の培養からはBacteroides fragilisが検出された．抗菌薬治療による保存的加療では軽快せず，左肋間小開胸による心膜開窓術を施行した．術後経過は良好で胸水培養も陰性であった．化膿性心外膜炎は難治性で予後も不良な疾患である．今回，Bacteroides fragilisによる化膿性心外膜炎という稀な症例に対して左肋間小開胸によるアプローチを選択し，良好な成績を得られたので報告する．
Abstract Background : Autologous pericardium is widely used as a plastic material in intracardiac structures, the pulmonary artery, and aortic valve leaflets. For reconstruction (AVRec) using Ozaki procedure, it has produced excellent clinical results within 10-year period. In-body tissue architecture (iBTA), which based on phenomenon of encapsulation foreign materials, can be to prepare autologous prosthetic tissues. In this preliminary study, we examined whether biosheets leaflet for...
Abstract Background : Chronic limb-threatening ischemia (CLTI) increases the risk of lower limb amputation if revascularization is not performed properly at an early stage. The use autologous venous conduits only option, especially for critically ill patients requiring below-the-knee bypass surgery, but it limited by a lack usable veins. Biotube Maker (BTM1), which based on so-called in-Body Tissue Architecture (iBTA) technology, mold in vivo production Biotube® regenerative artificial...
The parallel graft technique is valuable for high-risk patients who are unfit open repair and have complex aortic lesions, such as distal stent graft-induced new entry (SINE). patient had undergone thoracic descending replacement because of dilatation the arch after optimal medical therapy Type B dissection. After 9 years, a occurred at level diaphragm. He was treated with endovascular (TEVAR) due to rapid his back pain. However, SINE 1 month TEVAR. Therefore, we performed chimney maintain...