A5009097406- Aortic Disease and Treatment Approaches
- Cardiac Valve Diseases and Treatments
- Aortic aneurysm repair treatments
- Electrospun Nanofibers in Biomedical Applications
- Cardiac Structural Anomalies and Repair
- Infectious Aortic and Vascular Conditions
- Infective Endocarditis Diagnosis and Management
- Cardiac Imaging and Diagnostics
- Cardiac and Coronary Surgery Techniques
- Cardiac electrophysiology and arrhythmias
- Hemostasis and retained surgical items
- Advanced MRI Techniques and Applications
- Vascular Procedures and Complications
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Mechanical Circulatory Support Devices
- Tissue Engineering and Regenerative Medicine
- Cardiac, Anesthesia and Surgical Outcomes
- Pharmacy and Medical Practices
- Biochemical effects in animals
- Colorectal and Anal Carcinomas
- Neurofibromatosis and Schwannoma Cases
- Mindfulness and Compassion Interventions
- Blood transfusion and management
- Radiopharmaceutical Chemistry and Applications
Oita University
2015-2023
Oita University Hospital
2014-2022
University of Pennsylvania
2017-2021
Stanford Medicine
2021
Johns Hopkins University
2017
Daewoong Pharmaceutical (South Korea)
2017
University of Alabama at Birmingham
2017
Kokura Memorial Hospital
2006
Social Insurance Yokohama Central Hospital
1997
Abstract Restoration of coronary blood flow after a heart attack can cause reperfusion injury potentially leading to impaired cardiac function, adverse tissue remodeling and failure. Iron is an essential biometal that may have pathologic role in this process. There clinical need for precise noninvasive method detect iron risk stratification patients therapy evaluation. Here, we report magnetic susceptibility imaging large animal model shows infarct paramagnetic shift associated with duration...
Histologic evaluations revealed excessive accumulations of macrophages and absence fibroblastic interstitial cells in explanted bioprosthetic valves. Comprehensive gene protein expression analysis histology unveiled an accumulation fibrinogen plasminogen, activator infiltrated macrophages, from degenerated valve surfaces the spaces. These pathologies were completely reproduced a goat model replaced with autologous pericardium-derived aortic valve. Further preclinical animal experiments using...
There is a need for small diameter vascular substitutes in the absence of available autologous material. A diameter, long tissue engineered graft was developed using completely approach called "in body architecture technology (iBTA)". The aim this pilot study to evaluate "Biotubes", iBTA induced collagenous tubes, their potential use as bypass conduits.Biotubes (internal 4 mm, length 50 cm, wall thickness 0.85 mm) were prepared by subcutaneous embedding plastic moulds (Biotube Maker) three...
Endovascular aortic aneurysm repair (EVAR) has revolutionized the management of abdominal aneurysms (AAAs), with lower perioperative morbidity and mortality compared to conventional surgical repair. However, late secondary re-interventions after EVAR are still needed before rupture in many cases. A patient impending an AAA associated a type I endoleak 7 years who was successfully treated unique technique fixation proximal neck taking into account structure stent graft is reported. This...
86歳，女性．主訴は労作時呼吸困難．上行大動脈から腹部大動脈に及ぶ広範囲重複大動脈瘤を認めた．広範囲重複大動脈瘤に対し，上行弓部大動脈置換術，腹部デブランチ，胸部ステントグラフト留置術（TEVAR）の三期分割の方針とした．弓部置換時に左室ベントによる心尖部穿孔をきたし，フェルト補強で修復術を施行した．退院後，心尖部から左前胸部にかけて膿瘍を形成し，抗菌薬治療を開始した．2回の排膿ドレナージ術を施行したが，膿瘍は消失しなかった．各種培養は陰性であり，無菌性膿瘍として保存的加療では治療に難渋したため，心尖部大網充填術と腹部デブランチを同時施行した．術後経過は良好で，残存瘤に対しTEVARを施行することが可能となり，広範囲重複大動脈瘤の治療を完結できた．
Background and Purpose: Autologous pericardium is widely used for a plastic material in intracardiac structures, pulmonary artery, or aortic valve leaflets. Also reconstruction (AVRec: Ozaki Procedure), inducing excellent clinical results over 6 years, autologous after fixation with glutaraldehyde. In-body tissue architecture (IBTA) based on the encapsulation phenomenon of foreign materials can prepare prosthetic tissues. In this study, we an IBTA-based collagenous connective sheet...
症例は46歳，男性．突然の胸痛を主訴に搬送され，急性大動脈解離（St. A型）と診断された．緊急手術を施行したが，術後低心拍出量症候群となり，術後2日目に東洋紡型補助人工心臓装着に至った．術後10日目より胸腔ドレーンから連日1,000ml以上の排液を認めた．保存的治療を行ったが，排液量が増加したため，術後26日目に胸腔鏡下胸管結紮術を施行した．胸水排液量は著明に減少したものの，完全には治癒せず，定期的な胸腔穿刺を必要とした．術後67日目よりソマトスタチンアナログ製剤（オクトレオチド）100μg×2回/日の皮下注射を行ったところ，投与4日目より300ml/日以下となり，その後の増加は見られなかった．今回，胸部大動脈術後の乳糜胸にオクトレオチドを使用し，重篤な副作用なく，最終的に治癒せしめたことから，全身状態不良の症例でも試みる価値は十分あると考える．
Autologous pericardium is widely used as a plastic material in intracardiac structures, the pulmonary artery, and aortic valve leaflets. For reconstruction (AVRec) using Ozaki procedure, it has produced excellent clinical results over 10-year period. In-body tissue architecture (iBTA), which based on phenomenon of encapsulation foreign materials, can be to prepare autologous prosthetic tissues. In this preliminary study, we examined whether biosheets leaflet for glutaraldehyde-free AVRec by...
要旨：82 歳女性，主訴は腹痛。胸腹部大動脈瘤切迫破裂が疑われ，当院緊急搬送。手術は腎動脈下腹部大動脈を離断し，中枢側大動脈端と左総腸骨動脈をストレートグラフトで吻合した。離断した末梢側大動脈端を使用して腹部debranch を行い，翌日にステントグラフト内挿術を施行した。今回の手技で犠牲にする腰動脈を最少にすることが可能であった。対麻痺なく，軽快退院した。腰動脈の温存が対麻痺予防として有用である可能性を示唆する。
裂肛が慢性化した場合,肛門狭窄,肛門ポリープ,みはりイボなどを合併し、肛門痛の遷延のみならず排便障害や脱出症状をきたし,裂肛はさらに深掘れし保存的治療では難治性となるため手術適応となる.内括約筋レベルの肛門狭窄に対してLSISを行い,LSISだけでは解除不可能な肛門上皮レベルの高度狭窄例にはSSG法を行う.肛門括約筋に侵襲のかかる術式ゆえ愛護的に行わないと術後の肛門機能愁訴を招く恐れもあり注意深く行うべきである.
症例は64歳男性,右下腿の疼痛と運動麻痺が出現し,右下肢急性動脈閉塞症の診断で当院紹介となった.造影CTで右膝窩動脈以下の完全閉塞所見と,近位下行大動脈に結節状の血栓を認めた.心房細動を認めていたが,血液検査では凝固系異常を来しうる基礎疾患は認めなかった.血栓塞栓症再発の危険性があったため,大腿動脈-大腿静脈バイパス(F-F bypass)による部分体外循環,内視鏡補助下に約10 cmの左第5肋間小開胸で近位下行大動脈内血栓摘出術を施行した.病理所見で血栓と確定診断され,同時に採取した大動脈壁の内膜にアテローム変性を認めた.術後は合併症なく経過し,義肢を作製し自宅退院となった.直接経口抗凝固薬(アピキサバン)と抗血小板薬(アスピリン)を継続し,術後2年間再発なく経過している.