A5020386330- Cardiomyopathy and Myosin Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Function and Risk Factors
- Endometriosis Research and Treatment
- Ovarian cancer diagnosis and treatment
- Polyomavirus and related diseases
- Appendicitis Diagnosis and Management
- Cardiovascular Effects of Exercise
- Enhanced Recovery After Surgery
- Endometrial and Cervical Cancer Treatments
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Foreign Body Medical Cases
- Abdominal Trauma and Injuries
- Uterine Myomas and Treatments
- Acute Myeloid Leukemia Research
- Pelvic and Acetabular Injuries
- Advanced X-ray and CT Imaging
- Hematopoietic Stem Cell Transplantation
- Medical Imaging and Pathology Studies
- Medical Imaging Techniques and Applications
- Urinary and Genital Oncology Studies
- Mechanical Engineering and Vibrations Research
- Intraperitoneal and Appendiceal Malignancies
- Congenital heart defects research
University College London
2012-2023
Rutgers Cancer Institute of New Jersey
2010-2022
University of Alberta
2006-2022
Rutgers, The State University of New Jersey
2016-2022
Nirma University
2020-2022
University of Alberta Hospital
2010-2021
Alberta Hospital Edmonton
2018-2021
Kettering University
2019
Actinium Pharmaceuticals (United States)
2019
Noble’s Hospital
2016-2018
Background— Sarcomere protein mutations in hypertrophic cardiomyopathy induce subtle cardiac structural changes before the development of left ventricular hypertrophy (LVH). We have proposed that myocardial crypts are part this phenotype and independently associated with presence sarcomere gene mutations. tested hypothesis genetic pre-LVH (genotype positive, LVH negative [G+LVH−]). Methods Results— A multicenter case–control study investigated 22 other cardiovascular magnetic resonance...
Mutations in genes coding for sarcomeric proteins cause hypertrophic cardiomyopathy. Subtle abnormalities of the myocardium may be present mutation carriers without left ventricular hypertrophy (G+LVH-) but are difficult to quantify. Fractal analysis has been used define trabeculae noncompaction and identify normal racial variations. We hypothesized that measured by fractal cardiovascular magnetic resonance images abnormal G+LVH- patients, providing a preclinical marker disease...
Anderson-Fabry Disease (AFD) is an X linked lysosomal storage disorder caused by mutations in the α-galactosidase A gene. Some are associated with prominent and, many cases, exclusive cardiac involvement. The primary aims of this study were to determine incidence major events AFD and identify clinical genetic predictors adverse outcomes.We studied 207 patients (47% male, mean age 44 years, follow-up 7.1 years). Fifty-eight (28%) individuals carried that have been previously a predominant...
Background: Diffuse myocardial fibrosis (DMF) is important in cardiovascular disease, however until recently could only be assessed by invasive biopsy.We hypothesised that DMF measured T1 mapping elevated isolated systemic hypertension.Methods: In a study of well-controlled hypertensive patients from specialist tertiary centre, 46 (median age 56, range 21 to 78, 52 % male) and 50 healthy volunteers 45, 28 69, underwent clinical CMR at 1.5 T with (ShMOLLI) using the equilibrium contrast...
Transplantation is the surgical treatment of choice for end-stage organ failure. procedures performed in abdomen include liver, renal, pancreas, islet, intestinal, and multivisceral transplantations. Imaging plays a pivotal role posttransplantation setting monitoring transplant allograft screening complications. Knowledge techniques employed abdominal transplantation essential because it facilitates radiologic understanding interpretation anatomy. This article includes basic description...
Graft-versus-host disease (GVHD) is a major adverse effect associated with allogeneic stem cell transplant. Previous studies in mice indicated that administration of the probiotic Lactobacillus rhamnosus GG can reduce incidence GVHD after hematopoietic Here we report results from first randomized enteric regimen trial which allogenic patients were supplemented GG. Gut microbiome analysis confirmed previously reported gut association GVHD. However, clinical was terminated when interim did not...
Hypertrophic cardiomyopathy (HCM) is defined by pathological left ventricular hypertrophy (LVH). It the commonest inherited cardiac condition and a significant number of high risk cases still go undetected until sudden death (SCD) event. Plasma biomarkers do not currently feature in assessment HCM disease progression, which tracked serial imaging, or SCD stratification, based on imaging parameters patient/family history. There need for new plasma to refine monitoring improve patient...
Urogenital infections are one of the most common causes for a woman to visit gynecologist or urologist. The well-known association between abnormal vaginal microbial flora and its formidable risk in increased incidence urinary tract infection underscores importance understanding efforts needed maintain it, ensuring urogenital health. Surprisingly spite receive very less attention from medical fraternity. Growing awareness among people newer advances field has brought them into limelight....
We present a case of an internal carotid web, detected on duplex ultrasound and confirmed by CT angiography. To our knowledge, this is only the third reported in imaging literature. This vascular abnormality can cause clinically significant stenosis risk factor for recurrent embolic cerebrovascular events. Due to small size poor awareness among radiologists, webs are often under-diagnosed non-invasive modalities. Improved including knowledge salient features useful as early diagnosis leading...
Recovery in heart rate (HR) after exercise is a measure of autonomic function and prognostic indicator cardiovascular disease. The aim this study was to characterize recovery (HRR) determine its relation cardiac morphology patients with hypertrophic cardiomyopathy (HC). We studied 18 healthy volunteers 41 individuals HC. All underwent clinical assessment transthoracic echocardiography. Continuous beat-by-beat HR obtained during cardiopulmonary testing using finger plethysmography. HRR power...
Objective Reduction of left ventricular outflow tract obstruction (LVOTO) often improves symptoms in hypertrophic cardiomyopathy (HCM), but the correlation between exercise performance and measured LVOT gradients is weak. We investigated relationship LVOTO cardiorespiratory responses during exercise. Methods The study cohort included 70 patients with HCM (32 LVOTO, 55 male, age 47±13) attending a dedicated clinic 28 normal volunteers. All underwent cardiopulmonary testing simultaneous...
Anterior mitral valve leaflet (AMVL) elongation is detectable in overt and subclinical hypertrophic cardiomyopathy (HCM). We sought to investigate the dynamic motion of aorto-mitral apparatus understand behaviour AMVL mechanisms left ventricular outflow tract obstruction (LVOTO) predisposition HCM.Cardiovascular magnetic resonance imaging using a 1.5 Tesla scanner was performed on 36 HCM sarcomere gene mutation carriers without hypertrophy (G+LVH-), 31 patients with preserved ejection...
The objective of this study was to define the characteristic imaging appearances common renal cell carcinoma (RCC) subtypes.The Institutional Review Board approval obtained for HIPAA-compliant retrospective study, and informed consent waived. 520 patients (336 men, 184 women; age range, 22-88 years) underwent preoperative cross-sectional 544 RCCs from 2008 2013. clinical information were reviewed. Data analysis performed using parametric nonparametric statistics, descriptive receiver...
Specific radiological features identified by Brandser and Marsh were selected for the analysis of acetabular fractures according to classification Letournel Judet. The method employs a binary approach that requires observer allocate each feature one two groups. inter- intra-observer variances assessed. presence articular displacement, marginal impaction, incongruity, intra-articular fragments osteochondral injuries femoral head analysed similar method. These factors termed 'modifiers' are...